邻皮质软骨瘤1例

邻皮质软骨瘤，系罕见而独特的良性软骨类肿瘤。1992年我院收治1例。     

早期骨关节炎关节软骨改变的MR成像

骨关节炎早期主要是软骨改变，随着磁共振技术的进步，对关节软骨病变的早期发现、诊断、治疗及临床疗效评价有重要的意义。在复习关节软骨正常生化成分与结构、早期病理改变及MR成像基础上，就早期骨关节炎关节软骨改变的MR成像的技术进展予以综述。     

羊栖菜多糖复方制剂抗辐射作用的实验研究

目的 研究羊柄菜多糖复方制剂对γ射线照射小鼠的抗辐射作用.方法 将小鼠分为空白对照组、模型对照组及羊栖菜多糖复方制剂低[0.692g/(kg·d)]、中[2.075g/(kg·d)]、高[4.150g/(kg·d)]3个剂量组,以方格星虫提取物为阳性对照组,每天灌胃给药1次,灌胃2周后用60Co γ射线进行1次全身照射.测定小鼠外周血白细胞(WBC)、血小板和血细胞计数,以及脾指数(TI)、胸腺指数(SI)、骨髓有核细胞计数(BMWC)、血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量等指标.结果 3个剂量组小鼠与模型组比较,WBC均有上升趋势,但仅中剂量组在照后第14天与模型组差异有统计学意义(P＜0.05).3个剂量组TI均明显高于模型组(P＜0.05),SI和BMNC仅中、高剂量组明显高于模型组(P＜0.05),SOD低、中剂量组明显高于模型组(P＜0.05),MDA中、高剂量组低于模型组(P＜0.05或P＜0.01).结论 羊栖菜多糖复方制剂能有效提高小鼠的抗辐射能力.     

医源性杓状软骨脱位(附三例报告)

杓状软骨脱位除颈外伤所引起外,常因医疗操作如气管内插管麻醉、内窥镜检查、胃肠减压管或鼻饲管置入时操作粗疏损伤所引起,应引起注意。我们在近2年内遇到3例,报告如下:     

少见的软组织内良性软骨母细胞瘤一例

患者,女,32岁。偶然发现左肘窝有一肿物,无外伤史。查体:左肘前有一肿块约3×5cm,质硬,不移动,无明显压痛,局部皮肤颜色、皮温及感觉正常。肘部伸直正常,屈曲较健侧略受限。 X线检查:于左肘关节之前略偏外方显示1.5×2.5大小边缘不甚规则略呈分叶两团块状钙化阴影,肿块中有多数班点状、索条状钙化,正侧位片未见直接与骨相连接征象,桡骨头骨质未见破坏、增生及局部骨膜反应(图1、2)。     

从筋的生理特点认识筋的损伤

中医所谓的筋是筋络、筋膜、筋腱、软骨的总称。是骨以外的皮、肉、筋、脉等组织的概括。结合现代医学解剖，相当于现代解剖学的四肢和躯干部位的软组织，主要包括肌腱、筋膜、关节囊、韧带、椎间盘、关节软骨盘等软组织。各种外来暴力或慢性劳损等原因所造成的筋的损伤，称筋伤，俗称伤筋，即现代医学所指的软组织损伤。筋的损伤实际上是因为不同原因导致了筋的相应生理特点发生改变，其机能和结构出现异常。因而认清筋的生理特点，分析筋的生理特点是否发生改变对于判断筋是否发生损伤及损伤的性质、种类具有重要的作用。     

耳屏软骨—软骨膜复合体在听力重建术中的应用

目的：探讨用耳屏软骨-软骨膜复合体行听力重建术的疗效。方法：用自体耳屏软骨-软骨膜复合体重建鼓膜和听骨链，并根据听骨链是否完整而采取了不同的术式。结果：48耳手术穿孔均一期愈合，术后随访18个月-5年半，未见再穿孔，术前，术后骨，气导间距分别为22.1dBHL和6.8dBHL，术后较术前平均缩小15.3dBHL。结论：耳屏软骨-软骨膜复合体是修复鼓膜大穿孔的理想材料，并能起到槌骨和/或砧骨的作用。     

大鼠脂肪干细胞复合胶原-壳聚糖-硫酸软骨素三维支架构建组织工程软骨

Objective To evaluate the character of the collagen-chitosan-chondroitin sulfate scaffold seeded with rat adipose tissue-derived stromal cells. Methods A dipose tissue were harvested from 6 weeks old Wistar rats and the stromal cells were harvested by type Ⅰ collagenase and then cultured in vitro. Type Ⅰ collagen was fully mixed with chitosan, freeze-dried and cross-linked with chondroitin sulfate, then freeze-dried again and sterilized by ethylene oxide. The pore diameter, water content, porosity of the scaffold were tested. The adipose tissue-derived stromal cells were digested, seeded into the plates, scaffold, and cen-trifuged into pellet, and then induced into cartilage. MTT detection for cell proliferation was done. After 3 weeks, the cell morphology, and cell proliferation and adhesion were observed, and chondrngenic differenti-ation was also analyzed. Results The pore diameter, water content, porosity tested for the scaffold showed an appropriate form. Cell proliferation showed faster in the scaffold and pellet culture system after 5 day, there was still cell proliferation in the scaffold system after 14 days but no obvious changes in the pellet cul-ture system; ceils on the scaffold proliferated densely showed by histological staining, but there was a scaf-fold structure residues in the inner layer. The finding of type Ⅱ immunohistochemistry stain showed that cells express strong positive for type Ⅱ collagen in the scaffold and pellet culture system whereas it was weakly positive in the plate culture system; the specific mRNA for cartilage, type Ⅱ collagen, aggrecan and SOX-9 were expressed in all three systems showed by RT-PCR, but type X collagen was expressed continu-ously in the plate culture system and expressed after 21 days in the pellet culture system, whereas it was not detected in the collagen-chitosan-chondroitin sulfate scaffold system. Conclusion The parameters of the collagen-chitosan-chondroitin sulfate scaffold were suitable in our study. The results suggested that it can promote the adipose tissue-derived stromal cells proliferation and chondrogenic differentiation better than the plate and pellet culture systems and maintain the phenotype of chondrocytes well; it is the optimal choice for cartilage tissue engineering in the future.     

关节滑膜软骨瘤病32例报告

关节滑膜软骨瘤病又称滑膜骨软瘤病〔1〕,是一种少见的慢性关节滑膜增殖性疾病。我院自 1 980年 1月至 2 0 0 2年 1月共收治关节滑膜软骨瘤病 32例 ,现报告如下。1　临床资料1 1　一般资料 :本组 32例 ,男性 2 2例 ,女性 1 0例 ,年龄最小 1 8岁 ,最大 5 2岁 ,平均年龄 4 3岁。从发病到入院时间最短 3个月 ,最长 1 6年 ,平均 3 2年 ,其中发病于膝关节 2 2例 (左膝 1 2例 ,右膝 1 0例 ) ;髋关节 8例 (左髋 4例 ,右髋 4例 ) ;右肩关节 1例 ,右肘关节 1例 ,1 3例有关节外伤史。临床均表现为关节间歇性疼痛、肿胀 ,1 2例活动时弹响、摩擦感 ,5例…