新生儿高胰岛素血症41例临床分析

对１９９５年７月至１９９６年１２月收治的４１例新生儿高胰岛素血症进行临床分析，了解新生儿在某些病理状态，如窒息，小于胎龄儿（ＳＧＡ），感染等情况下，可使胰岛β细胞的功能受影响，而发生高胰岛素血症，其中６３．４％发生低血糖，低血糖可使神经系统受到损害，因此对此类人密切检测，及时诊治至关重要。     

颅内蛛网膜囊肿的MRI诊断

随着MRI临床应用增多和深入,认识良性颅内囊性损害的特征并与其它囊性病变相鉴别,对患者的治疗及预后判断显得尤为重要,为此作者就MRI诊断的60例蛛网膜囊肿进行了分析。材料与方法自1993年3月至1995年10月期间经MRI检查的3020例头部患者中,检出60例蛛网膜囊肿。60例患者年龄15～68岁。男35例,女25例。临床表现     

椎体包虫病的MRI诊断

目的 :探讨脊椎包虫病影像学改变的病理学基础及其MRI临床诊断价值。材料和方法 :对 19例经手术及病理证实的脊椎包虫病的X线及MRI进行回顾性分析、分类。结果 :包虫的寄生生长方式决定了其膨胀性、多房性生长的影像特点 ,MRI上具有特征性。结论 :MRI对评价脊椎包虫病具有重要意义 ,尤其在显示脊椎包虫与邻近组织结构关系方面有独到之处。     

血府化瘀口服液的制备及临床应用

目的：研究血府化瘀口服液的制备、质量控制及临床应用效果。方法：确定处方组成和制备工艺，按《中国药典》规定进行质量控制，并进行临床应用。结果：成品经鉴别、检查符合《中国药典》要求。用于治疗视网膜静脉血栓病例157例，有效率为98％。结论：血府化瘀口服液的疗效肯定。制剂稳定，可长期应用。     

咪唑安定 芬太尼 丙泊酚序贯联合注射在结肠镜下息肉切除术中的应用

目的探讨咪唑安定联合芬太尼及丙泊酚在结肠镜下息肉切除术中的效果及安全性。方法将结肠镜下治疗患者总共238例,按患者意愿分为麻醉组152例,普通组86例,麻醉组在肠镜检查前静脉注射咪唑安定、芬太尼及丙泊酚,比较2组患者治疗成功率及到达盲肠的时间,记录检查前后的血压、心率、血氧饱和度及满意度情况。结果麻醉组在进镜时间、治疗成功率、并发症及满意度方面均优于普通组,差异有统计学意义(P<0.05),安全性方面差异无统计学意义(P>0.05)。结论咪唑安定联合芬太尼及丙泊酚在结肠镜下息肉切除术中的应用具有明显的优势,较高的安全性,值得基层临床医院大力推广。     

Lower Phosphorylation of p38 MAPK Blocks the Oxidative Stress-induced Senescence in Myeloid Leukemic CD34~+CD38~- Cells

Leukemia seems to depend on a small population of "leukemia stem cells (LSCs)" for its growth and metastasis. However, the precise surviving mechanisms of LSCs remain obscure. Cellular senescence is an important obstacle for production and surviving of tumor cells. In this study we investigated the activated state of a pathway, in which reactive oxygen species (ROS) induces cellular senescence through DNA damage and phophorylation of p38 MAPK (p38), in myeloid leukemic CD34+CD38- cells. Bone marrow samples were obtained from patients with acute myeloid leukemia (AML, n=11) and chronic myeloid leukemia (CML, n=9). CD34+CD38- cells were isolated from mononuclear cells from these bone marrow samples, and K562 and KG1a cells (two kinds of myeloid leukemia cell lines) by mini-magnetic activated cell sorting. Hematopoietic stem cells (HSCs) from human cord blood served as controls. Intracellular ROS level was detected by flow cytometry. DNA damage defined as the γH2AX level was measured by immunofluorescence staining. Real-time RT-PCR was used to detect the expression of p21, a senescence-associated gene. Western blotting and immunofluo-rescence staining were employed to determine the p38 expression and activation. The proliferation and apoptosis of CD34+CD38- cells were detected by MTT assay and flow cytometry. Our results showed that ROS and DNA damage were substantially accumulated and p38 was less phosphorated in myeloid leukemic CD34+CD38- cells as compared with HSCs and H2O2-induced senescent HSCs. Furthermore, over-phosphorylation of p38 by anisomycin, a selective activator of p38, induced both the senescence-like growth arrest and apoptosis of CD34+CD38- cells from K562 and KG1a cell lines. These findings suggested that, although excessive accumulation of oxidative DNA damage was present in LSCs, the relatively decreased phosphorylation of p38 might help leukemic cells escape senescence and apoptosis.     

失语症的命名错误

各种类型的失语症患者在命名时均可出现命名错误。常见的命名错误有语义性错语、音素性错语、无关语词错语、中文一字相关错语、迂回语、新词错语、否定反应、持续言语和调位错语。这些错语类型提示命名过程有不同层次的损害。因此 ,在失语症评价时 ,应对错语进行认真分析。1命名错误的类型语义性错语是指患者命名的词即替代词 ,在意义上与靶词 (ｔａｒｇｅｔｗｏｒｄ)有联系 :①替代词是靶词的上位词 ,如用“植物”代替“花” ;②替代词是靶词的同范畴词 ,如把“丈夫”说成“妻子” ;③替代词与靶词在语境上有联系 ,如把“骆驼”说成“沙漠…     

高血压脑出血患者时间护理的临床应用

目的:分析高血压脑出血患者行时间护理的临床应用效果。方法:随机选取63例高血压脑出血患者,按就诊时间分为对照组(30例)和观察组(33例)。对照组患者给予常规护理措施,观察组患者给予时间护理措施,对比两组患者临床护理效果。结果:两组患者临床治疗效果对比,观察组良好率为60.6%,对照组良好率为33.3%,差异具有统计学意义(P<0.05)。治疗后两组患者日常生活自理能力以及肢体运动功能均较治疗前有所改善,两组患者治疗后结果对比,观察组得分高于对照组,差异具有统计学意义(P<0.05)。结论:时间护理可有效提高高血压脑出血患者的临床治疗效果,具有较高的临床应用价值。     

聚丙烯酰胺水凝胶隆乳术后哺乳期乳腺脓肿的治疗体会

目的:总结我院用乳腺脓肿置管冲洗引流的方法治疗聚丙烯酰胺水凝胶隆乳术后哺乳期乳腺脓肿的经验,提高聚丙烯酰胺水凝胶隆乳术后哺乳期乳腺脓肿的治疗效果.方法:我院自2006年1月～2006年7月治疗6例注射式丰乳后诊断为乳腺脓肿患者,均采用置管冲洗引流术,术后继续冲洗引流,拔管后加压包扎,隔日换药.结果:3例术后2周内愈合;3例术后1周愈合.结论:采用置菅冲洗引流术治疗聚丙烯酰胺水凝胶隆乳术后哺乳期乳腺脓肿方法简单,治疗效果好,但患者回乳时间反水凝胶注射组织粘连情况影响术后愈合时间.