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41.
基于系统药理学探索甘草有效成分甘草甜素的药理作用机制 总被引:3,自引:0,他引:3
该文拟通过一系列系统药理学方法探讨甘草甜素的药理作用机制。运用文本挖掘工具,获得甘草甜素主要相关疾病;在Polysearch和PubChem 数据库获得甘草甜素的靶蛋白;运用网络可视化软件,构建甘草甜素靶蛋白质相互作用网络;借助基因本位论 (GO) 工具分析甘草甜素蛋白质群;通路富集分析甘草甜素靶蛋白的作用通路。文本挖掘结果表明甘草甜素主要相关疾病有慢性丙型肝炎、慢性肝炎、肝炎、HIV病毒、肝癌等;基因本位论分析结果表明甘草甜素主要通过修饰蛋白、修饰染色质等作用发挥生物学功能;信号通路富集结果表明甘草甜素主要作用蛋白与MAPK信号通路、Toll样受体信号通路、神经营养因子信号通路、癌症途径以及细胞凋亡等信号通路相关。可见,甘草甜素可能主要通过调控MAPK信号通路、Toll样受体信号通路等多途径发挥其药理作用。综合运用系统药理学的方法可以实现快速而全面的分析药物的药理作用。 相似文献
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M. Marmiroli L. Pagano F. Pasquali A. Zappettini V. Tosato C. V. Bruschi 《Nanotoxicology》2016,10(1):84-93
The use of cadmium sulphide quantum dots (CdS QDs) is increasing, particularly in the electronics industry. Their size (1–10?nm in diameter) is, however, such that they can be taken up by living cells. Here, a bakers’ yeast (Saccharomyces cerevisiae) deletion mutant collection has been exploited to provide a high-throughput means of revealing the genetic basis for tolerance/susceptibility to CdS QD exposure. The deletion of 112 genes, some associated with the abiotic stress response, some with various metabolic processes, some with mitochondrial organization, some with transport and some with DNA repair, reduced the level of tolerance to CdS QDs. A gene ontology analysis highlighted the role of oxidative stress in determining the cellular response. The transformation of sensitive mutants with centromeric plasmids harbouring DNA from a wild type strain restored the wild type growth phenotype when the complemented genes encoded either HSC82, DSK2 or ALD3. The use of these simple eukaryote knock-out mutants for functional toxicogenomic analysis will inform studies focusing on higher organisms. 相似文献
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Michael Rustin 《Infant Observation》2013,16(1):35-52
This paper explores a young child's experience of entering the emotional field of the preschool playground. Esther Bick's ideas about primitive mental states are drawn on to consider how psychic holding can occur through the skin in a physical way until the child is able to find containment from the preschool group. The metaphor of a ‘second skin’ is extended to describe the preschool group's response to the new child. Bion's idea about ‘a group mentality’ is used to think about unconscious processes occurring in the group as efforts are made to contain infantile anxieties. It is suggested that the capacity to contain feelings and face frustration is the first step towards socialisation of the growing child. 相似文献
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R Rosenberg 《Acta psychiatrica Scandinavica》1991,84(5):408-412
Some major themes in the philosophy of science are briefly reviewed, considering epistemological, ontological and ethical problems in modern psychiatry. A conception of realism at the ontological, empiricism at the methodological level and humanistic ethics is proposed. Meta-psychiatry is suggested as a theoretical discipline integrating clinical research methodology and philosophy of science. 相似文献
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We have developed an updated version of the Animal Toxin Database (ATDB 2.0) that provides a new bioinformatics resource for analyzing toxin-channel (T-C) interactions. Data on more than 54,000 T-C interactions, including 9193 high-confidence interactions, has been extracted, formatted and mapped to toxin and ion channel databases. The interaction data can be accessed easily through a new network browser on the website at http://protchem.hunnu.edu.cn/toxin. This resource may be useful for sequence pattern recognition and prediction of the function of new toxins. 相似文献
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