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排序方式: 共有2999条查询结果,搜索用时 46 毫秒
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Sarah Bertoli Etienne Paubelle Emilie Brard Estelle Saland Xavier Thomas Suzanne Tavitian Marie‐Virginie Larcher Franois Vergez Eric Delabesse Audrey Sarry Franoise Huguet Clment Larrue Claudie Bosc Thomas Farge Jean Emmanuel Sarry Mauricette Michallet Christian Rcher 《European journal of haematology》2019,102(2):131-142
Spontaneous remission (SR) of acute myeloid leukemia (AML) represents a rare phenomenon and is usually of short duration although long‐term remissions are reported. Indeed, mechanisms underlying SR remain unclear, but it is suggested that immunactivation, e.g. caused by infections, plays an important role. Here we report on a patient who suffered from pneumonia and simultaneously experienced very late hematologic AML relapse seventeen years after allogeneic blood stem cell transplantation (allo‐BSCT). Surprisingly in parallel to recovery from pneumonia peripheral blood count which previously showed pancytopenia, had normalized and bone marrow (BM) aspiration revealed spontaneous remission of AML. To the best of our knowledge we here report on the latest AML relapse after allo‐BSCT experiencing SR. 相似文献
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Nicholas S. Phillips Yin Ting Cheung John O. Glass Matthew A. Scoggins Wei Liu Robert J. Ogg Daniel A. Mulrooney Ching‐Hon Pui Leslie L. Robison Wilburn E. Reddick Melissa M. Hudson Kevin R. Krull 《Pediatric blood & cancer》2020,67(3)
Survivors of childhood acute lymphoblastic leukemia (ALL) treated with chemotherapy only are at risk for neurocognitive impairment. Regions of interest were identified a priori based on glucocorticoid receptor distribution, and sex‐stratified multivariable linear regression models were used to test associations between brain MRI morphology and total number of intrathecal injections, and serum concentration of dexamethasone and methotrexate. Compared with controls, ALL survivors have persistently smaller volumes in the bilateral cerebellum (P < 0.005), hippocampal subregions (P < 0.03), temporal lobe regions (P < 0.03), frontal lobe regions (P < 0.04), and parietal lobe regions (precuneus; P < 0.002). Long‐term problems with learning may be related to residual posttreatment brain differences. 相似文献
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《The journal of maternal-fetal & neonatal medicine》2013,26(11):2369-2371
Objective: Antenatal corticosteroids are extensively given in pregnancies with threatened preterm labour as a prophylactic method to reduce some kinds of neonatal diseases. Dexamethasone is one kind of commonly used corticosteroid, but controversies still remain whether it leads to adverse effects on neonatal long-term development or not. The purpose of this study was to investigate the influence of prenatal exposure to one or two dosages of dexamethasone on neonatal physical and cognitive development of children at 1, 3 and 6 years of age. Methods: This was a retrospective cohort study. The body length, head circumference and body weight were measured in every infant and child to evaluate physical development. The mental development index (MDI) and a psychomotor development index (PDI) were used to evaluate mental and cognitive development in children of ages 1 year and 3 years while verbal intelligence quotient (VIQ) and performance intelligence quotient (PIQ) scores were used to evaluate mental and cognitive development in children of age of 6 years. There were 1554 infants at 1 year, 1328 children at 3 years and 1297 preschool children at 6 years followed. Results: There were no significant differences between antenatal dexamethasone exposure groups and antenatal dexamethasone non-exposure groups on physical development index and MDI, PDI, VIQ and PIQ. Conclusions: The results of this investigation suggested that one or two dosages of antenatal dexamethasone is safe for the use of inevitable preterm birth. 相似文献
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Darrene Nguyen Alex Hui Andrea Weeks Miriam Heynen Elizabeth Joyce Heather Sheardown Lyndon Jones 《Materials》2012,5(4):684-698
The purpose of this study was to determine the effect of the covalent incorporation of hyaluronic acid (HA) into conventional hydrogel and hydrogels containing silicone as models for contact lens materials on the uptake and release of the fluoroquinolone antibiotic ciprofloxacin and the anti-inflammatory steroid dexamethasone phosphate. A 3 mg/mL ciprofloxacin solution (0.3% w/v) and a 1 mg/mL dexamethasone phosphate solution (0.1%) was prepared in borate buffered saline. Three hydrogel material samples (pHEMA; pHEMA TRIS; DMAA TRIS) were prepared with and without the covalent incorporation of HA of molecular weight (MW) 35 or 132 kDa. Hydrogel discs were punched from a sheet of material with a uniform diameter of 5 mm. Uptake kinetics were evaluated at room temperature by soaking the discs for 24 h. Release kinetics were evaluated by placing the drug-loaded discs in saline at 34 °C in a shaking water bath. At various time points over 6–7 days, aliquots of the release medium were assayed for drug amounts. The majority of the materials tested released sufficient drug to be clinically relevant in an ophthalmic application, reaching desired concentrations for antibiotic or anti-inflammatory activity in solution. Overall, the silicone-based hydrogels (pHEMA TRIS and DMAA TRIS), released lower amounts of drug than the conventional pHEMA material (p < 0.001). Materials with HA MW132 released more ciprofloxacin compared to materials with HA MW35 and lenses without HA (p < 0.02). Some HA-based materials were still releasing the drug after 6 days. 相似文献
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Tasar A Yanturali S Topacoglu H Ersoy G Unverir P Sarikaya S 《The Journal of emergency medicine》2008,35(4):363-367
The objective of this study was to investigate whether treatment with single-dose dexamethasone can provide relief of symptoms in acute exudative pharyngitis. A prospective, randomized, double-blinded, placebo-controlled clinical trial was undertaken over a 3-month period in a university-based Emergency Department. The study included all consecutive patients between 18 and 65 years of age presenting with acute exudative pharyngitis, sore throat, odynophagia, or a combination, and with more than two Centor criteria. Each patient was empirically treated with azithromycin and paracetamol for 3 days. The effects of placebo and a fixed single dose (8 mg) of intramuscular injection of dexamethasone were compared. The patients were asked to report the exact time to onset of pain relief and time to complete relief of pain. After completion of the treatment, telephone follow-up regarding the relief of pain was conducted. A total of 103 patients were enrolled. Thirty patients with a history of recent antibiotic use, pregnancy, those who were elderly (> 65 years of age) and patients who failed to give informed consent were excluded. Forty-two patients were assigned to the placebo group and 31 were assigned to the intramuscular dexamethasone group (8-mg single dose). Time to perceived onset of pain relief was 8.06 ± 4.86 h in steroid-treated patients, as opposed to 19.90 ± 9.39 h in the control group (p = 0.000). The interval required to become pain-free was 28.97 ± 12.00 h in the dexamethasone group, vs. 53.74 ± 16.23 h in the placebo group (p = 0.000). No significant difference was observed in vital signs between the regimens. No side effects and no new complaints attributable to the dexamethasone and azithromycin were observed. Sore throat and odynophagia in patients with acute exudative pharyngitis may respond better to treatment with an 8-mg single dose of intramuscular dexamethasone accompanied by an antibiotic regimen than to antibiotics alone. 相似文献
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目的:探讨短程大剂量山莨菪碱联用地塞米松治疗危重型多发伤患者的临床效果,并阐述作用机制。方法:临床纳入危重型多发伤患者70例,根据随机数字表法分为研究组与对照组。研究组给予山莨菪碱联合地塞米松,对照组给予门冬氨酸钾镁联合地塞米松。观察两组患者临床疗效,同时对比治疗前后两组患者肿瘤坏死因子(tumor necrosis factor,TNF)、脂质过氧化物(lipid hydroperoxide,LPO)水平。此外,观察两组患者治疗前后肝肾功能等安全性指标的变化。结果:研究组病死率为11.43%,对照组病死率为22.86%,差异有统计学意义(P0.05);但治疗后,研究组血TNF、LPO水平分别为(77.02±12.77)μmol/L、(2.94±0.72)μmol/L,而对照组血TNF、LPO水平分别为(112.46±15.91)μmol/L、(5.03±1.03)μmol/L,差异均有统计学意义(P0.05);治疗前后,两组患者肝肾功能等指标水平差异均无明显变化,差异无统计学意义。结论:短程大剂量山莨菪碱联用地塞米松能够显著降低危重型多发伤患者的死亡率,且应用安全可靠,其作用机制可能在于抑制机体TNF、LPO水平。 相似文献
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Mustafa Arslan MD Ramazan Çiçek MD Hülya Üstün Kalender MD Hüseyin Yilmaz MD 《Current therapeutic research》2011,(1):1-12