门诊患者挂号与就诊时间调查分析

目的:了解门诊患者挂号与就诊时间分布情况,为门诊科学管理提供理论依据. 方法:对2004-02西京医院门诊患者挂号和就诊时间进行调查分析. 采用SPSS 11.0软件分别计算上午、下午挂号和就诊时间用中位数和四分位间距. 结果:全院2004-02门诊总人次为46 737人次,上午患者挂号时间的中位数是8:59,四分位间距为98 min,开始就诊时间的中位数是9:46,四分位间距为107 min;下午患者挂号时间的中位数是14:50,四分位间距为39 min,开始就诊时间的中位数是15:27,四分位间距为68 min. 结论:门诊患者挂号与就诊时间存在明显的高峰,等待就诊时间太长,且不同科室存在差别,应采取相应措施,缩短等待就诊时间.     

不同天干、岁运时段出生人群后天罹患疾病倾向的差异性研究

目的基于运气理论,探索不同天干、岁运时段出生人群后天罹患疾病倾向的差异。方法收集北京中医药大学东直门医院17 394例患者资料,归纳全部患病人数及五脏系统疾病患病人数在不同天干、岁运时段的分布,并进行统计学分析。结果在全部17 394例患者中,全部患病人数及不同五脏系统疾病的患病人数在不同天干、岁运时段出生人群中分布差异均有统计学意义（P〈0.01）,其中全部患病人数及心系、肺系等疾病的患病人数,在不同天干、岁运时段的分布差异均有统计学意义（P〈0.01）。结论不同天干、岁运时段出生的人,其后天罹患疾病的倾向有一定差异。     

果糖-1,6-二磷酸一镁的稳定性研究

目的 :研究果糖 1,6 二磷酸一镁的稳定性 ,并确定产品有效期。方法 :通过影响因素 (高温、高湿、强光照射 ) ,加速试验 ,长期试验 ,采用高度专一性的酶法测定果糖 1,6 二磷酸一镁的含量变化 ,纸电泳法分析有关物质。结果 :果糖 1,6 二磷酸一镁 ,在高温、高湿环境下不稳定 ,而对光较稳定。结论 :果糖 1,6 二磷酸一镁 ,模拟上市包装 ,在温度 ( 2 5± 2 )℃ ,相对湿度 ( 60± 10 ) %的条件下保存 2 4个月 ,仍符合质量标准     

Predictive power of various models for longitudinal attachment level change

Abstract Several statistical models that have been suggested in the periodontal literature for describing longitudinal attachment level changes, such as the gradual loss, single-burst, multiple-burst, and random walk models as well as other models introduced in this paper are compared by their power to predict future attachment loss. The data used in this analysis is from 1061 sites of 8 subjects, with moderate to severe periodontal disease, monitored monthly for about a year. This study found that none of the suggested models could significantly outperform the naive mean predictor, which predicts the future attachment level from the past mean. It was also found that no single model, such as the burst, gradual, or random walk, together with measurement error can fully explain the variation in the data. These results indicate that in the course of one year, the attachment level change may not follow the same model. Consequently, a model that fits well to past data cannot be accurately extended to the future.     

急性重症胰腺炎继发腹腔感染的临床分析

目的分析急性重症胰腺炎(SAP)继发性腹腔感染的发生情况。方法对60例SAP病例进行回顾性分析,观察继发性腹腔感染与APACHEⅡ评分、Ranson预后指标、住院时间、死亡率的关系。按治疗方法将病例分为非手术治疗组、早期手术治疗组、非手术中转手术治疗组,比较腹腔感染发生率。结果继发性腹腔感染的发生率为35.0%。感染与非感染两组的APACHEⅡ评分、Ranson预后指标无统计学差异,腹腔感染组病例住院时间长(P<0.05),死亡率高但无统计学意义(P>0.05)。与非手术治疗组比较,早期手术治疗组病例腹腔感染发生率高(P<0.05)。继发性腹腔感染的病原菌以革兰阴性菌为主(占70.0%)。结论SAP病例采用早期手术治疗有较高的腹腔继发感染发生率。继发性腹腔感染的发生延长了SAP病例的住院时间。     

基于“病-药-量”探讨《中华医典》含竹沥中药方剂相应规律的数据挖掘

目的 分析《中华医典》中含有竹沥中药方剂“病-药-量”的相应规律,为竹沥的临床诊疗应用及深入研发提供参考。方法 收集整理《中华医典》中含有竹沥的中药方剂,录入Excel 2016构建临证方药数据库,对其病症、证型、药物使用频次、功效类别、性味归经、剂型及用量等进行统计分析,运用SPSS Statistics 22.0、IBM SPSS Modeler 18.0软件进行关联规则、聚类分析等数据挖掘。结果 共收集含竹沥方剂349首,主治病证分类共99种,其中高频病证（≥20次）主要为“中风”“痰饮”“咳嗽”,治疗“中风”证型以风痰瘀阻为主,“痰饮”以饮停胃肠为主,“咳嗽”以痰热郁肺为主;组方中使用频次≥50次的药物有19味,使用频次较高的有生姜、甘草、茯苓、陈皮等,药物功效种类以化痰止咳平喘药、补虚药、清热药为主;药性使用频次最高的为寒性药,其次为温性药,药味多选用甘、苦、辛味,药物归经以脾、胃、心经为主;高频病症剂型及药物用量分析显示,治疗“中风”时,剂型多为汤剂,竹沥用量多为100 mL,核心药物配伍重用防风以祛风化痰,改善脑络痹阻;治疗“痰饮”时,剂型多为丸剂,竹沥用量为200 mL...     

Stability and Beyond-Use Date of a Compounded Thioguanine Suspension

Background: Thioguanine (TG) is available only in the form of 40 mg tablets in the United States, and the patient population in which TG is used comprises mostly children. Recognizing its importance as a therapeutic agent and limited stability data for its compounded preparation, the United States Pharmacopoeia has listed TG in its priority list of compounded preparations monographs. Objective: The goal of the present study was to generate stability data and establish a beyond-use date for compounded TG suspension. Methods: Suspensions were compounded using TG tablets and ORA-Plus and ORA-Sweet as vehicles. A robust high-performance liquid chromatography method was developed and validated. TG and guanine (G) in suspensions were quantified immediately after compounding and at regular intervals for 90 days. Physical stability of suspensions was evaluated by observation of organoleptic properties. Results: Results from the study indicate that average TG levels in suspensions remained above 90% of the starting concentration and G formation was less than 2.5% for 90 days. There was no statistically significant difference in the amount of TG degraded over 90 days between suspensions stored at room temperature and in refrigerated conditions. There was also no statistically significant difference in G concentration of suspensions between day 0 and day 90. Conclusion: TG suspensions are stable for 90 days when stored at room temperature or refrigerated conditions and the beyond-use date can be set to 90 days.     

Generalized Richards model for predicting COVID-19 dynamics in Saudi Arabia based on particle swarm optimization Algorithm

COVID-19 pandemic is spreading around the world becoming thus a serious concern for health, economic and social systems worldwide. In such situation, predicting as accurately as possible the future dynamics of the virus is a challenging problem for scientists and decision-makers. In this paper, four phenomenological epidemic models as well as Suspected-Infected-Recovered (SIR) model are investigated for predicting the cumulative number of infected cases in Saudi Arabia in addition to the probable end-date of the outbreak. The prediction problem is formulated as an optimization framework and solved using a Particle Swarm Optimization (PSO) algorithm. The Generalized Richards Model (GRM) has been found to be the best one in achieving two objectives: first, fitting the collected data (covering 223 days between March 2^nd and October 10, 2020) with the lowest mean absolute percentage error (MAPE = 3.2889%), the highest coefficient of determination (R² = 0.9953) and the lowest root mean squared error (RMSE = 8827); and second, predicting a probable end date found to be around the end of December 2020 with a projected number of 378,299 at the end of the outbreak. The obtained results may help the decision-makers to take suitable decisions related to the pandemic mitigation and containment and provide clear understanding of the virus dynamics in Saudi Arabia.     

羊水过少90例临床分析

目的 :探讨羊水过少相关因素、B超诊断标准、对围生儿的影响及正确的处理方法。方法 :回顾分析我院 2 0 0 1年 1月至 12月收治的羊水过少 90例临床资料。结果 :羊水过少发生率为 3 .2 %。以AFI≤ 8 为标准拟诊羊水过少 ,敏感性为 0 .84,特异性为 0 .83 ,如以AFI <9 为标准 ,敏感性为 0 .96,特异性为 0 .5 6。羊水过少组妊高征、IUGR的发生率 ( 10 .0 % ,4.4% )明显高于正常组 ( 2 .5 % ,0 % ,) (P <0 .0 5 ) ;羊水过少组延期妊娠的发生率 ( 43 .3 % )明显高于正常组 ( 19.1% ) (P <0 .0 1)。羊水过少组 ( 2 8.8% ,17.8% )的羊水粪染率、胎儿宫内窘迫率明显高于对照组 ( 11.7% ,5 .8% ) (P <0 .0 1)。羊水过少组剖宫产率为 95 .6% ,无孕产妇及新生儿死亡。结论 :以AFI≤ 8cm为羊水过少B超诊断标准是适当的 ,敏感性、特异性均较好。羊水过少的发生与延期妊娠、妊高征、IU GR关系密切 ,及时处理 ,能有效降低围生儿病死率。羊水过少能明显增加羊水粪染率、胎儿宫内窘迫率 ,羊水过少一经确诊 ,应除外胎儿畸形 ,及时采取措施 ,必要时以剖宫产终止妊娠为宜     

Victimization history and victim-assailant relationship as factors in recovery from sexual assault

The present study investigated the psychological aftermath of sexual assault in a probability sample of university women, with an emphasis on how various aspects of a victim's lifetime sexual assault history and their relationship with their assailant(s) mediate posttraumatic recovery. Victims were almost twice as likely as nonvictims to meet given criteria for a psychiatric case. Surprisingly, date rape victims were as distressed as victims of chronic childhood assault, possibly because of the ambiguous nature of the assault circumstance. Also, repeated victimization was related to denial, a symptom of posttraumatic stress. Denial was discussed in regard to the likelihood of its increasing the risk of revictimization.