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21.
M J Kahn W Schandevijl G Philipi H L Frank 《Clinica chimica acta; international journal of clinical chemistry》1977,80(3):513-518
Comparison of the levels of alpha1-AT, alpha2-M, inter alpha-AT, C1 inactivator and antiplasmin and global antitrypsin activity in a group of normal phenotype PI MM individuals, a group of normal individuals with phenotypes with intermediate alpha1 AT activities and alpha2-AT-deficient persons show that alpha1-AT contributes more than 90 percent of the total antitrypsin activity of normal plasma. AT III and fast reacting antiplasmin are shown to contribute to the remaining activity. It can be assumed that due to test conditions the antitrypsin activity of alpha2-M is not assessed. C1 inactivator and inter alpha1-AT do not contribute to a perceptible extent to the overall antitrypsin activity estimated according to the method of Eriksson (Eriksson, S. (1965) Acta Med. Scand. 177, 1). 相似文献
22.
L. Berrens P. Bruynzeel 《Clinica chimica acta; international journal of clinical chemistry》1976,70(3):337-342
Two commercially available methods of total serum IgE determination have been evaluated, viz: the radioimmunosorbent test (RIST) and the assay by single radial immunodiffusion (RID). RIST was found a suitable and rapid method for the wide range of IgE concentrations to be expected in the sera of an allergic population. The RID method has a lower limit of detection of about 1000 I.U./ml; over this value, both techniques provided statistically correlated results. However, for technological reasons RID was considered less suitable for routine application. 相似文献
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Matheus H.L. Arts Carolien E.M. Benraad Denise Hanssen Peter Hilderink Linda de Jonge Paul Naarding Peter Lucassen Richard C. Oude Voshaar 《Journal of the American Medical Directors Association》2019,20(9):1150-1155
ObjectivesTo examine the level of frailty and somatic comorbidity in older patients with medically unexplained symptoms (MUS) and compare this to patients with medically explained symptoms (MES).DesignCross-sectional, comparative study.SettingCommunity, primary care, and secondary healthcare to recruit patients with MUS in various developmental and severity stages and primary care to recruit patients with MES.ParticipantsIn total, 118 patients with MUS and 154 patients with MES, all aged ≥60 years.MethodsFrailty was assessed according to the Fried criteria (gait speed, handgrip strength, unintentional weight loss, exhaustion, and low physical activity), somatic comorbidity according to the self-report Charlson comorbidity index, and the number of prescribed medications.ResultsAlthough patients with MUS had less physical comorbidity compared with patients with MES, they were prescribed the same number of medications. Moreover, patients with MUS were more often frail compared with patients with MES. Among patients with MUS, physical frailty was associated with the severity of unexplained symptoms, the level of hypochondriacal beliefs, and the level of somatisation.Conclusions and implicationsDespite a lower prevalence of overt somatic diseases, patients with MUS are more frail compared with older patients with MES. These results suggest that at least in some patients age-related phenomena might be erroneously classified as MUS, which may affect treatment strategy. 相似文献
26.
Pauline H. Croll Daniel Bos Meike W. Vernooij Banafsheh Arshi Frank R. Lin Robert J. Baatenburg de Jong M. Arfan Ikram André Goedegebure Maryam Kavousi 《Journal of the American Medical Directors Association》2019,20(12):1617-1622.e1
ObjectivesCardiovascular disease may be linked to hearing loss through narrowing of the nutrient arteries of the cochlea, but large-scale population-based evidence for this association remains scarce. We investigated the association of carotid atherosclerosis as a marker of generalized cardiovascular disease with hearing loss in a population-based cohort.DesignCross-sectional.SettingA population-based cohort study.Participants3724 participants [mean age: 65.5 years, standard deviation (SD): 7.5, 55.4% female].MethodsUltrasound and pure-tone audiograms to assess carotid atherosclerosis and hearing loss.ResultsWe investigated associations of carotid plaque burden and carotid intima-media thickness (IMT) (overall and side-specific carotid atherosclerosis) with hearing loss (in the best hearing ear and side-specific hearing loss) using multivariable linear and ordinal regression models. We found that higher maximum IMT was related to poorer hearing in the best hearing ear [difference in decibel hearing level per 1-mm increase in IMT: 2.09 dB, 95% confidence interval (CI): 0.08, 4.10]. Additionally, third and fourth quartile plaque burden as compared to first quartile was related to poorer hearing in the best hearing ear (difference: 1.06 dB, 95% CI: 0.04, 2.08; and difference: 1.55 dB, 95% CI: 0.49, 2.60, respectively). Larger IMT (difference: 2.97 dB, 95% CI: 0.79, 5.14), third quartile plaque burden compared to first quartile (difference: 1.24 dB, 95% CI: 0.14, 2.35), and fourth plaque quartile compared to first quartile (difference: 2.12 dB, 95% CI: 0.98, 3.26) in the right carotid were associated with poorer hearing in the right ear.Conclusions and ImplicationsCarotid atherosclerosis is associated with poorer hearing in older adults, almost exclusively with poorer hearing in the right ear. Based on our results, it seems that current therapies for the prevention of cardiovascular disease may also prove beneficial for hearing loss in older adults by promoting and maintaining inner ear health. 相似文献
27.
William R. Faber Bouke de Jong Henry J.C. de Vries Jim E. Zeegelaar Fran?oise Portaels 《Emerging infectious diseases》2015,21(3):497-499
We report Buruli ulcer in a man in the Netherlands. Phenotyping of samples indicate the Buruli pathogen was acquired in Suriname and activated by trauma on return to the Netherlands. Awareness of this disease by clinicians in non–Buruli ulcer–endemic areas is critical for identification. 相似文献
28.
Aims To study the impact of implementing smoke‐free workplace and hospitality industry legislation on smoking behaviour. Design, setting and participants A cross‐sectional population survey from 2001 to 2008 (n ≈ 18 000 per year) was used to assess trends and seasonal patterns in smoking and quitting, and to examine whether changes could be observed after the workplace smoking ban in the Netherlands in 2004 and the hospitality industry ban in 2008. Measurements Outcome measures were smoking prevalence, quit attempts and successful quit attempts. Interactions with educational level (socio‐economic status) and bar visiting (exposure to the hospitality industry ban) were tested. Findings The workplace ban was followed by a decrease in smoking prevalence (OR = 0.91, P < 0.001), but the hospitality industry ban was not (OR = 0.96, P = 0.127). Both bans, especially the workplace ban, were followed by an increase in quit attempts and successful quit attempts: workplace ban, OR = 1.31, P < 0.001; OR = 1.49, P < 0.001; hospitality industry ban, OR = 1.13, P = 0.013; OR = 1.44, P < 0.001. The workplace ban had a larger effect on successful quitting among higher‐educated (OR = 0.35, P < 0.001) than on lower‐educated respondents (OR = 0.74, P = 0.052). The hospitality industry ban had a larger effect on quit attempts among frequent bar visitors (OR = 1.48, P = 0.003) than on non‐bar visitors (OR = 0.71, P = 0.014). Conclusions A workplace smoking ban in the Netherlands was followed by more changes in smoking and quitting than a hospitality industry ban. The hospitality industry ban only appeared to have an impact on quit attempts, and not on smoking prevalence. 相似文献
29.
The incidence of suspected myocardial infarction in Dutch general practice in the period 1978-1994 总被引:2,自引:0,他引:2
van der Pal-de Bruin K.M.; Verkleij H.; Jansen J.; Bartelds A.; Kromhout D. 《European heart journal》1998,19(3):429-434
Aim To evaluate how the incidence of suspected myo-cardial infarctionhas developed from 1978 to 1994 and to study the incidence ofconfirmed acute myocardial infarction in Dutch general practicesduring the period 19911994. Methods In three periods (1978, 19831985 and 19911994)the incidence of suspected myocardial infarction has been registeredby the Dutch Sentinel Practice Network. This isa registration system that obtains data from general practitionerscovering about 150000 persons. During the period 19911994the incidence of confirmed myocardial infarction was also registered. Results For men, the incidence rate of suspected myo-cardial infarctiondecreased by 28% from 4·7 per 1000 in 1978 to 3·4per 1000 in the period 19911994. For women, the incidencefell by 23% from 2·6 per 1000 in 1978 to 2·0 per1000 in the period 19831985 and stabilized thereafter.The most pronounced decrease in the incidence of suspected myocardialinfarction during the period 19781994 occurred in bothmen and women aged 4564. In the period 19911994,the standardized incidence rate of confirmed myocardial infarctionis 1·7 per 1000 for men and 0·9 per 1000 for women. Conclusions These data suggest that the incidence of suspected myocardialinfarction has declined substantially between 1978 and 1994both for men and for women; this decline is most pronouncedin the age group 4564. 相似文献
30.
Liesbeth Mollema Irene Anhai Harmsen Emma Broekhuizen Rutger Clijnk Hester De Melker Theo Paulussen Gerjo Kok Robert Ruiter Enny Das 《Journal of medical Internet research》2015,17(5)