青蒿素提取条件研究

以干青嵩味末为原料，分别用乙醚、氯仿、正己烷、石油醚搅拌提取青蒿素，结果表明石油醚是较适宜的提取介质。对石油醚提取青蒿素的工艺条件，如温度、时间、溶剂及搅拌速度等进行了较系统研究，确定了较佳的工艺操作条件。     

β-Galactofuranose-containing structures present in the cell wall of the saprophytic fungus Cladosporium (Hormoconis) resinae

A peptidogalactomannan was isolated from mycelia of Cladosporium (Hormoconis) resinae and characterized using methylation–fragmentation analysis, partial acid hydrolysis and ¹H and ¹³C-NMR spectroscopy. The galactomannan component was a branched structure and consisted of a main chain containing (1→6)-linked α-d-Manp residues substituted at O-2 by side chains containing (1→2)-linked α-d-Manp residues. β-d-Galf residues were present as side chains of 3–4 units that are (1→5)-interlinked. This structure is very similar to a pGM isolated from Aspergillus fumigatus and differs from that of Cladosporium werneckii (currently named Hortaea werneckii), with this pGM and other fungal galactomannans having single terminal (1→6)-linked β-Galf residues. The importance of the carbohydrate moiety of Cladosporium resinae pGM in immunoassays was also demonstrated. On FACS examination, a decrease (60%) in rabbit serum anti- C. resinae binding to C. resinae conidia occurred when this serum had been previously incubated with pGMs from C. resinae and A. fumigatus or with mannoprotein from Candida parapsilosis, suggesting the presence of cross-reactive determinants in these fungi.     

皮纹图像数据库系统的设计和实现

目前,皮纹学研究的方法和手段还有待于提高,而利用计算机技术构建功能强大的,快速灵活的皮纹图像数据库可以使皮纹研究工作大为轻松而且更有效率.本文根据皮纹图像的特点,再结合计算机发展的最新技术介绍了皮纹图像数据库系统的设计.它包括了选择哪一种数据库平台、数据库的内部、外部构成、数据库设计所遵循的物理、逻辑原则、数据库表的设计以及客户端应用程序的设计等.测试结果表明:该系统比较满意地实现预期目标.     

针刺配合红外偏振光治疗过敏性鼻炎疗效观察

目的观察针刺配合红外偏振光治疗过敏性鼻炎的临床疗效。方法将60例过敏性鼻炎患者随机分为治疗组30例和对照组30例,治疗组采用针刺配合红外偏振光治疗,对照组仅采用针刺治疗。治疗2个疗程后,观察两组疗效的差别。结果治疗组总有效率为96.7%,优于对照组76.7%,两组经统计学处理差异具有统计学意义（P〈0.05）。结论针刺配合红外偏振光疗法治疗过敏性鼻炎总有效率优于单纯针刺。     

眼震电刺激器的研制

眩晕症与前庭神经系统的功能异常和病理变化有着直接联系,眼震电图仪是前庭神经系统功能检查和评定的重要设备.本文首先介绍了眼震电的概念和眼震电刺激器的功能,比较了几种常见的眼震电刺激器,重点介绍了LED视屏刺激器.眼震电刺激器可以产生定标、凝视、扫视、视跟踪、视动等多种刺激方式,有控制和驱动电路简单、诱发效果好、环境适应性好、易于升级、成本低等优点,在临床上有着广泛的应用前景.     

Efficient Approximation of P-value of the Maximum of Correlated Tests, with Applications to Genome-Wide Association Studies

Genome-wide association study (GWAS), typically involving 100,000 to 500,000 single-nucleotide polymorphisms (SNPs), is a powerful approach to identify disease susceptibility loci. In a GWAS, single-marker analysis, which tests one SNP at a time, is usually used as the first stage to screen SNPs across the genome in order to identify a small fraction of promising SNPs with relatively low p-values for further and more focused studies. For single-marker analysis, the trend test derived for an additive genetic model is often used. This may not be robust when the additive assumption is not appropriate for the true underlying disease model. A robust test, MAX, based on the maximum of three trend test statistics derived for recessive, additive, and dominant models, has been proposed recently for GWAS. But its p-value has to be evaluated through a resampling-based procedure, which is computationally challenging for the analysis of GWAS. Obtaining the p-value for MAX with adjustment for the covariates can be even more time-consuming. In this article, we provide a simple approximation for the p-value of the MAX test with or without adjusting for the covariates. The new method avoids resampling steps and thus makes the MAX test readily applicable to GWAS. We use simulation studies as well as real datasets on 17 confirmed disease-associated SNPs to assess the accuracy of the proposed method. We also apply the method to the GWAS of coronary artery disease.     

透过TGN1412事件处理看药品不良事件的应对模式

通过对TGN1412不良事件及其发生后各方反应的回溯性分析,探讨监管部门、媒体、专家和企业对药品不良事件的反应模式及其应对模式的效率与效果。处理药品不良事件的关键是过程公开透明、信息提供充分、程序科学严谨。通过对药品不良事件的及时、有效处理,以保障公众用药安全。     

激光汽化活体生物组织的传热过程分析

目的：研究激光汽化生物活体组织的传热过程及其影响因素，方法：基于血液灌注率温度依赖型Pennes生物传热方程，建立激光与生物活体组织热相互作用的一般模型，研究组织表面发生汽化相变，中间组织出现热凝结，内层组织发生温升的过程，由此探讨组织中的激光传输特性，以及血液灌注率和边界冷却等因素的影响情况。结果：通过数值计算，得出活体组织表面汽化速度及内部温度分布，研究表明，活体组织对不同激光的吸收能力，血液灌注率与边界冷却放松择组织汽化速度，组织凝结过程及温度分布有显著影响。结论：该模型可用于预测激光汽化蚀除组织的过程，分析结果对激光临床应用具有理论指导意义。     

一年生黄芩总黄酮含量的动态变化研究

目的：分析一年生黄芩在生殖生长期间，不同部位黄酮含量的动态变化，探讨黄芩的生长特性，为黄芩规范化栽培及开发利用提供依据。方法：应用分光光度法测定不同发育阶段黄芩不同部位总黄酮含量。结果：黄芩不同时期各部位总黄酮含量由高到低的排列顺序是：繁殖部位〉根〉叶〉茎。结论：繁殖部位不同器官总黄酮含量变化趋势基本一致；叶状苞片总黄酮的含量高于叶的含量；茎和花枝总黄酮的含量变化趋势基本一致。