静泵鲁南欣康治疗高血压急症急性降压疗效观察

目的：探讨鲁南欣康静泵维持治疗高血压急症急性降压作用。方法：对54例高血压急症患者用鲁南欣康20mg加入30ml液中连续静泵入体内,观察用药后5min、10min、15min、30min、60min、120min的血压、心率和不良反应。结果：静泵5min后血压开始下降,但无统计学意义（P〉0．05）、10min后血压有显著降低（P〈0．01）,以10min-30min血压下降最显著（P〈0．01）;各与前次血压下降比较,用药后收缩压10min-30min有显著差异（P〈0．05和P〈0．01）;舒张压均有不同程度降低,但无统计学意义;与治疗前比较,收缩压和舒张压下降幅度为20．09％、19．83％;用药后120min,总有效率为96．30％;心率亦有下降（P〈0．01）。结论：静泵鲁南欣康是高血压急症急性降压有效药物,最适用于高血压性心衰、急性心梗、心绞痛、高血压危象等,且副作用少,但对肾性高血压急症疗效较差。     

伪人参皂苷GQ对异丙肾上腺素致大鼠急性心肌缺血的改善作用

目的：探讨新化合物伪人参皂苷GQ（PGQ）对异丙肾上腺素致急性心肌缺血大鼠心电图改变的保护作用。 方法：取Wistar大白鼠50只,随机分为生理盐水组、异搏定对照组及PGQ大、中、小3个剂量组,每组10只。舌下静脉注射预防给药PGQ 3.0、6.0和12.0 mg·kg^-1及异搏定0.2 mg·kg^-1,然后静脉注射2.0 mg·kg^-1异丙肾上腺素,测量心电图（ECG）标Ⅱ、胸Ⅰ(Ⅴ₁)和胸Ⅱ(Ⅴ₂)ST段的变化。 结果：标Ⅱ导联、Ⅴ₁导联、Ⅴ₂导联PGQ小、中、大剂量组ST段在各时间点抬高不明显,ST段抬高幅度低于盐水组（P<0.05,P<0.01,P<0.001）。结论：PGQ能明显降低异丙肾上腺素引起的ST段抬高,具有改善大鼠异丙肾上腺素 致急性心肌缺血心电图改变的作用。     

脂氧素A4对心肌缺血再灌注损伤的保护作用

Objective To investigate the roles of lipoxin A4, an endegenous lipid mediator with wide anti-inflammatory fea- tures, in attenuating myocardial ischemia-reperfusion injury and the possible mechanisms. Methods Thirty male KM mice were divid- ed randomly into three groups, 10 in each: ischemia-reperfusion group (group A), lipoxin A4 (0.1 mg/kg) group (group B) and Zn- PP (Zinc protoporphyrin Ⅸ, 25 mg/kg)phus lipoxin A4 (0.1 mg/kg)group (group C). A ischemia-reperfusion heart model was de- veloped by ligating the lift anterior descending branch of the coronary artery. A dine of 10% dehydrated alcohol in 0.2 ml for group A, a dose of isochoric lipoxin A4 for group B and a dose of isochoric ZnPP + lipoxin A4 for group C was infused into the ascending aorta through a catheter, which was kpassing the right common carotid artery, 30 minutes after reperfusion. The concentration of serum TNF-α, activities of serum crestine kinase(CK) and lactate dehydrogenase (LDH), activities of myeloperoxidase (MPO) and malond- ialdehyde (MDA) and the cell apoptosis rate in the myocardial tissue were measured 5 hours after reperfusion. Pathological features of the inflammatory infiltration in the myocardium were also observated.Results As compared with group A, the inflammatoryry infiltra- tion in the ischemic and necrotic regions tithe myocardium was reduced, with group C in the intermediate range. The serum activities of CK and LDH wine significantly lower in group B and C than that in group A, and the lowest activities were detected in group B. Similar findings were observed for MPO, an indicator for neutrophil infiltration, and MDA, an indictor for cell injury caused by oxy- gen radicals, in the myocardium. The concentration of TNF-α and the rate of cadiocyte apoptosis were decreased significantly in group B(P < 0.01). ZnPP, an inhibitor of heine oxygenase (HO)-1, attenusted the above protective effects of lipoxin A4 significantly (P<0.05). Conclusion Lipoxin A4 has protective effects against myocardial ischemia-reperfusion injury, and HO-1 may have a potential role in the protectve mechanisms of lipoxin A4, probably pertly by means of reducing the production of reactive oxygen spe- cies and TNF-α, decreasing the activation and infiltration of neutrophils, alleviating inflammatory damage and avoiding apoptosis.     

洁尔阴和中药煎剂治疗阴道炎的临床疗效对比分析

自2005-2008年用成都恩威公司生产的恩威牌洁尔阴治疗滴虫性、霉菌性和老年性阴道炎80例,并和同期用中药黄柏、苦参、蛇床子、苍术等煎剂外用治疗滴虫性霉菌性和老年性阴道炎40例对照观察均收到了较好的疗效,现总结如下：     

洁尔阴和中药煎剂治疗阴道炎的临床疗效对比分析

自2005～2008年用成都恩威公司生产的恩威牌洁尔阴治疗滴虫性、霉菌性和老年性阴道炎80例,并和同期用中药黄柏、苦参、蛇床子、苍术等煎剂外用治疗滴虫性霉菌性和老年性阴道炎40例对照观察均收到了较好的疗效,现总结如下     

经皮腔内冠状动脉支架置入术的护理体会

2008年6月-2009年5月，我院行冠状动脉病变经皮腔内冠状动脉介入术（PCI）128例，现将护理体会报告如下。     

紫丁香的化学成分的研究

紫丁香(Syringa oblata Lindl)别名丁香、紫花丁香为木犀科(Oleaceae)丁香属(Syringa) 植物,该植物约19种,我国有15种.地域分布广泛,多分布于辽宁、北京、河北、陕西、河南等地.     

安普索在呼吸系统疾病的临床应用

安普索(Ambrohexal)是由德国赫素大药厂生产的祛痰药物.我院在2005年11月～2007年1月应用安普索祛痰治疗,疗效满意,现报告如下. 1 材料与方法 1.1选择对象,各种急慢性伴有牯稠痰液症状的呼吸道疾病患者.其中慢性支气管炎、阻塞性肺气肿并感染30例;支气管扩张症2例;肺感染5例;急性支气管炎3例.随机分为治疗组15例,对照组25例.     

133例心脏移植供心保护回顾分析

目的总结133例心脏移植的供心获取及其保护经验并做回顾分析。方法武汉协和医院心脏外科2008年9月至2014年5月共完成133例原位心脏移植,其中非停搏供心103例,停搏供心30例。非停搏供心经主动脉根部灌注4℃改良St.Thomas液,供心快速停搏,取下供心后再灌注8℃康斯特保护液(HTK液)并置于HTK液中低温浸泡保存。停搏供心经主动脉根部灌注8℃HTK液,取下供心后再灌注HTK液并置于HTK液中保存。在供心修剪时均经主动脉根部再次灌注HTK液。结果非停搏供心组,92例供心自动复跳,11例电除颤复跳;热缺血时间(3.25±2.25)min,冷缺血时间(253.22±136.73)min,术后主动脉内球囊反搏(IABP)使用率9.5%,术后三周左室射血分数(LVEF)值(65.52±6.72)%,术后一年生存率92.55%。停搏供心组,23例供心自动复跳,7例电除颤复跳。热缺血时间(5.78±2.82)min,冷缺血时间(179.12±52.43)min,术后IABP使用率10.1%,术后三周LVEF值(65.78±7.22)%,术后一年生存率91.07%。结论本中心对两类供心采用不同获取及保护方法均确切有效,扩大了边缘供心的使用范围,提高了手术疗效。     

子宫背带式缝合术在剖宫产产后出血中的临床应用

目的：探讨子宫背带式缝合术在治疗剖官产产后出血中的应用价值。方法：对30例发生剖宫产术中宫缩乏力性出血病例采用子宫背带式缝合术治疗,观察其止血效果。结果：30例治疗后宫缩好转,出血停止,无一例因血液循环不良或再出血而再次手术或子宫切除,无并发症发生。结论：子宫背带式缝合术具有操作简单、止血迅速可靠、保留子宫且无并发症发生等优点,是治疗剖宫产产后出血行之有效的外科止血方法。