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71.
沈阳地区76例非何杰金淋巴瘤的分类及其免疫表型病理分析 总被引:4,自引:0,他引:4
目的:探讨我国沈阳地区非何杰金淋巴瘤(NHL)的病理特点及免疫组化表型分析。方法:对76例NHL按照WHO新分类进行病理观察和10种抗体免疫表型测定。结果:B系占78.9%,其中弥漫性大B细胞淋巴瘤(DLBL)最多;其次为MALT型(+/-单核细胞样B细胞)及淋巴浆细胞性淋巴瘤(LPL)。T系占21.1%,以外周T非特殊型最多。CD79a对B-NHL染色阳性率达100%,未见与T细胞的交叉反应。CD3对T-NHL染色阳性率为88%,与B细胞仅有5%的交叉反应。结论:我国沈阳地区NHL以DLBL和外周T非特殊型为最多见,结内单核B和淋巴浆细胞性比例较高。CD79a和CD3分别是具有高度敏感性和特异性的B、T细胞标志抗体。 相似文献
72.
73.
The extracellular matrix can regulate vascular cell migration, proliferation, and survival: relationships to vascular disease 总被引:10,自引:0,他引:10
Raines EW 《International journal of experimental pathology》2000,81(3):173-182
The extracellular matrix (ECM) of the normal artery wall is a collection of fibrous proteins and associated glycoproteins embedded in a hydrated ground substance of glycosaminoglycans and proteoglycans. These distinct molecules are organized into a highly ordered network that are closely associated with the vascular cells that produce them. In addition to providing the architectural framework for the artery wall that imparts mechanical support and viscoelasticity, the ECM can regulate the behaviour of vascular cells, including their ability to migrate, proliferate and survive injury. The composition of the ECM is different within intimal lesions of atherosclerosis, which are composed of monocytes and lymphocytes from the circulation and smooth muscle cells (SMC) that migrate from the media to the intima (Ross 1993, 1999), and these differences may contribute to the altered phenotype of vascular cells within lesions. This review will briefly outline the ECM changes observed in atherosclerosis and restenosis and the potential relationship of these changes to altered vascular cell functions. 相似文献
74.
神经系统副肿瘤综合征(paraneoplastic neurological syndrome,PNS)是肿瘤通过远隔效应累及神经系统的一组罕见的免疫介导性疾病,其临床症状多样,通常伴有特异性的神经抗体。2021年,国际专家组修订了2004年PNS诊断标准,提出了新的临床评分系统,突出强调了“表型-抗体-肿瘤”的关联性。本研究回顾近年文献,围绕新标准,对PNS的临床诊断进展作一综述。 相似文献
75.
睡眠呼吸暂停综合征患者T细胞,NK细胞功能的研究 总被引:4,自引:0,他引:4
目的:检测睡眠呼吸暂停综合征(SAS)患者外周血T淋巴细胞、NK细胞的变化,探讨SAS对细胞免疫功能的影响。方法:应用APAAP桥联酶标法测定外周血淋巴细胞表型。结果:SAS患者组CD3^+细胞与正常对照组差异无显著性(P〉0.05),CD4^+、CD4^+/CD8^+、CD16^+、CD25^+细胞SAS组均低于正常对照组,而CD8^+细胞高于正常对照组(P〈0.05,P〈0.01)。结论:SA 相似文献
76.
目的:比较人正常,增生和癌变前列腺组织中PSP94和PSP57mRNA的表达情况。方法:提取事故死亡的正常成年人前列腺组织及手术得到的增生和前列腺癌组织总RNA,进行RT-PCR,其产物分别以PSP94和PSP57共有的外显子及PSP94外显子Ⅲ作探针进行Southern blotting分析;RT-PCR产物经克隆后进行序列测定。结果:三种前列腺组织中均有PSP94和PSP57mRNA的表达;人 相似文献
77.
Clémence Jacquin Emilie Landais Céline Poirsier Alexandra Afenjar Ahmad Akhavi Nathalie Bednarek Caroline Bénech Adeline Bonnard Damien Bosquet Lydie Burglen Patrick Callier Sandra Chantot-Bastaraud Christine Coubes Charles Coutton Bruno Delobel Margaux Descharmes Jean-Michel Dupont Vincent Gatinois Nicolas Gruchy Sarah Guterman Abdelkader Heddar Lucas Herissant Delphine Heron Bertrand Isidor Pauline Jaeger Guillaume Jouret Boris Keren Paul Kuentz Cedric Le Caignec Jonathan Levy Nathalie Lopez Zoe Manssens Dominique Martin-Coignard Isabelle Marey Cyril Mignot Chantal Missirian Céline Pebrel-Richard Lucile Pinson Jacques Puechberty Sylvia Redon Damien Sanlaville Marta Spodenkiewicz Anne-Claude Tabet Alain Verloes Gaelle Vieville Catherine Yardin François Vialard Martine Doco-Fenzy 《American journal of medical genetics. Part A》2023,191(2):445-458
Chromosome 1p36 deletion syndrome (1p36DS) is one of the most common terminal deletion syndromes (incidence between 1/5000 and 1/10,000 live births in the American population), due to a heterozygous deletion of part of the short arm of chromosome 1. The 1p36DS is characterized by typical craniofacial features, developmental delay/intellectual disability, hypotonia, epilepsy, cardiomyopathy/congenital heart defect, brain abnormalities, hearing loss, eyes/vision problem, and short stature. The aim of our study was to (1) evaluate the incidence of the 1p36DS in the French population compared to 22q11.2 deletion syndrome and trisomy 21; (2) review the postnatal phenotype related to microarray data, compared to previously publish prenatal data. Thanks to a collaboration with the ACLF (Association des Cytogénéticiens de Langue Française), we have collected data of 86 patients constituting, to the best of our knowledge, the second-largest cohort of 1p36DS patients in the literature. We estimated an average of at least 10 cases per year in France. 1p36DS seems to be much less frequent than 22q11.2 deletion syndrome and trisomy 21. Patients presented mainly dysmorphism, microcephaly, developmental delay/intellectual disability, hypotonia, epilepsy, brain malformations, behavioral disorders, cardiomyopathy, or cardiovascular malformations and, pre and/or postnatal growth retardation. Cardiac abnormalities, brain malformations, and epilepsy were more frequent in distal deletions, whereas microcephaly was more common in proximal deletions. Mapping and genotype–phenotype correlation allowed us to identify four critical regions responsible for intellectual disability. This study highlights some phenotypic variability, according to the deletion position, and helps to refine the phenotype of 1p36DS, allowing improved management and follow-up of patients. 相似文献
78.
79.
目的:探讨解剖Y型钢板的临床应用价值。方法:报告36例解剖Y型钢板内固定肱骨远端粉碎性骨折,进行临床分析讨论,其中列,女8例,平均年龄36.8岁。36例中均行肘后标准切口尽骨鹰嘴截骨暴整个肱骨远端,Y型钢板、螺钉内固定。结果:本组随访1~5年,其中优良率86.2%。结论:解剖Y型钢板治疗治疗肱骨远端粉碎骨折,效果确切,术后有利早期活动关节,减少并发症。 相似文献
80.
The occurrence of nephrosis in the first 3 months of life is rare and is termed ’congenital nephrotic syndrome.’ The congenital
nephrotic syndrome is a group of heterogeneous diseases with a clinical course that differs markedly from the childhood nephrotic
syndrome. The coexistence of a congenital nephrotic syndrome and gonadal dysgenesis in a 46,XY karyotype with normal female
external genitalia is extremely rare. Frequent severe infections are often seen in the Finnish type, but sepsis leading to
death is rare in the neonatal onset of gonadal dysgenesis. This report describes an unusual case of complete XY gonadal dysgenesis
in a 46,XY female neonate with the congenital nephrotic syndrome and overwhelming sepsis.
Received: 4 January 1999 / Revised: 24 May 1999 / Accepted: 25 May 1999 相似文献