儿童白癜风378例临床分析

目的：通过分析378例儿童白癜风的临床资料,了解儿童白癜风的临床特点。方法：采取调查问卷方式收集378例儿童白癜风门诊患者临床资料并进行整理、统计分析。结果：儿童患者共378例,其中男183例（48.2%）,女195例（51.8%）,平均年龄为（9.56±2.21）岁,平均病程为（20.0±22.08）个月,平均发病年龄为（7.69±2.31）岁,局限性白癜风多见,好发季节为夏季,43例（11.4%）有家族史,262例（69.3%）处于进展期,18例（4.8%）伴有晕痣,偏食56例（14.8%）、外伤史22例（5.8%）、精神因素16例（4.2%）是儿童白癜风主要的诱发因素,城乡患儿发病率有显著性差异（P〈0.05）,伴发自身免疫性疾病少见。结论：儿童型白癜风可能是一种特殊类型的白癜风。     

Recent onset vitiligo on acral areas treated with phototherapy: need of early treatment

In vitiligo, the effect of phototherapy depends on lesional location. While face and neck lesions generally show good responses, acral areas are resistant to phototherapy. We describe two cases of recent onset vitiligo on acral areas that showed an excellent response with phototherapy. These results suggest that even acral areas in vitiligo can be markedly improved by phototherapy if it has a recent onset.     

他克莫司软膏联合窄谱中波紫外线治疗面颈部白癜风疗效观察

目的:评价外用0.1%他克莫司软膏联合窄谱中波紫外线(NB-UVB)治疗面、颈部白癜风的临床疗效和不良反应.方法:将82例面颈部自癜风患者随机分成3组.A组:外用0.1%他克莫司软膏联合NB-UVB照射.B组:单独给予NB-UVB照射.C组:单独外用0.1%他克莫司软膏.疗程均为16周.试验结束时依据治疗前、后患者皮损的照片进行疗效评价.结果:治疗结束后,A、B、C3组有效率分别为78.6%(22/28),48.1%(13/27),51.9%(14/27);A组有效率与B、C两组相比.差异有统计学意义(P值均<0.05).A组与C组的复色开始平均时间相比,差异无统计学意义(P>0.05),但二者分别与B组相比,差异均有统计学意义(P值均<0.05).A组、c组中患者不同分期皮损的有效率差异有统计学意义(P<0.05),B组差异则无统计学意义(P>0.05).3组患者中不同部位皮损的疗效比较差异均无统计学意义(P值均>0.05).3组患者治疗部位出现灼热感、瘙痒的概率很低,且症状轻微.结论:他克莫司软膏治疗面、颈部白癜风起效快、疗效好、不良反应少,联合NB-UVB照射能进一步提高疗效.     

新型涂布法黑素细胞移植系统治疗白癜风临床观察

目的:观察新型涂布黑素细胞移植系统治疗白癜风的临床疗效?方法:配制以人重组粒细胞集落刺激因子(recombinant human granulocyte colony-stimulating factor,rhG-CSF)为主要生长因子的培养基,混合卡波姆凝胶构成一种涂布载体系统用于黑素细胞移植治疗白癜风,按拟定标准进行疗效评估?结果:所有患者均有> 20%以上复色,其中6例复色面积超> 90%,11例复色70%~80%,15例复色30%~50%,有效率100%?84.4%的患者呈均匀复色,无明显斑驳现象?所有患者未出现不良反应?结论:新型涂布法黑素细胞移植系统治疗白癜风是一种安全?有效的方法?     

Vitiligo: an update on current pharmacotherapy and future directions

Introduction: Vitiligo is a common pigmentary skin disorder, characterized by the appearance of white macules on the skin, mucosal or hair. Treatment is often a tough challenge and involves a wide range of therapies.

Areas covered: This review focuses on available first- and second-line pharmacological treatments for vitiligo. In particular, the mechanisms of action, the main indications, the efficacy and the most important side effects are reviewed. Moreover, a brief discussion is provided, regarding other nonpharmacological treatments, such as phototherapy and surgical options, due to their importance and successful outcomes in vitiligo treatment. Finally, a concise overview regarding the future directions in vitiligo therapy is presented.

Expert opinion: The promising outcomes reported here demonstrate that it is possible to achieve a satisfactory and often stable repigmentation of vitiligo lesions. Topical corticosteroids, calcineurin inhibitors, phototherapy and photochemotherapy represent the first-line therapeutic options, due to their safety and efficacy, whereas vitamin D analogues, targeted phototherapy, oral corticosteroids and surgery should be used as second-line therapies. Other therapies, such as antioxidants, can be used in association with other therapeutic options, whereas depigmenting agents should be used only in cases of extensive vitiligo, recalcitrant to other treatments.     

8-甲氧补骨脂素脂质体对小鼠黑素瘤细胞黑素生成影响的研究

目的探讨 8 -甲氧补骨脂素脂质体 (LMOP)对B16F小鼠黑素瘤细胞增殖、黑素含量、酪氨酸酶活性的影响。方法采用体外培养的小鼠B16F黑素瘤细胞株 ,以等浓度的 8-甲氧补骨脂素 (MOP)为对照 ,用MTT法测定细胞增殖情况 ;NaOH裂解法测定黑素合成 ;多巴氧化法测定酪氨酸酶活性。结果与等浓度MOP相比 ,LMOP低浓度 (10～ 5 0 μmol/L)时显著提高酪氨酸酶活性和黑素含量 (P <0 .0 5 ) ,高浓度 (10 0～ 2 0 0 μmol/L)时对细胞的抑制作用更显著 (P <0 .0 5 )。 结论用脂质体作为MOP的载体可以显著提高MOP对靶细胞的作用 ,为LMOP制剂治疗白癜风的临床应用提供了实验依据。     

332例儿童型白癜风临床观察

目的通过分析332例儿童型白癜风的临床资料,了解此型白癜风的临床特点. 方法运用SPSS 10.0软件分析资料.结果儿童型白癜风平均发病年龄为7.61岁,临床类型以局限型多见,好发季节为夏季, 伴发自身免疫性疾病少见.结论儿童型白癜风是一种特殊类型的白癜风.