甲硝唑注射液引起癫痫发作1例并相关文献检索分析

目的探讨静脉滴注甲硝唑注射液后引起癫痫发作的原因及其防治措施。方法对1例静脉使用甲硝唑注射液引起癫痫发作的案例进行分析,并通过文献检索,对甲硝唑所致的癫痫发作的各种因素进行文献分析。结果甲硝唑注射液能引起癫痫发作,特别是使用高剂量甲硝唑及老年患者容易诱发癫痫。结论临床在使用甲硝唑注射液时应重点关注患者年龄,注意使用时间间隔,避免使用高剂量甲硝唑,从而减少诱发癫痫症状。     

HPLC法测定痤疮清软膏经皮给药后大鼠体内甲硝唑的浓度及药时曲线研究

目的:建立HPLC法测定痤疮清软膏经皮给药后大鼠体内中甲硝唑含量。方法:采用反相高效液相色谱法,Phenomsil C18柱(250mm×4.6mm,5μm)色谱柱;流动相:甲醇-水(10:90);检测波长:277nm;柱温:30℃;进样量为20μL;流速:1.0mL.min-1。结果:方法检出限为0.212μg/mL;甲硝唑在0.212~6.784μg/mL范围内线性良好,r=0.9991;样品加标回收率为96.2%,RSD=3.5。结论:该方法准确、稳定,有良好的重现性和较高的灵敏度。     

高效液相色谱法检测除螨祛痘类化妆品中甲硝唑和替硝唑

摘要：目的建立同时测定除螨祛痘类化妆品中甲硝唑和替硝唑的高效液相色谱（HPLC）法。方法采用Diamonsil（钻石）C18柱（250mm×4．6mm,5μm）,以0．05mol／L磷酸二氢钾溶液（用磷酸调pH至3．5）-甲醇（80：20）为流动相,检测波长为310nm。结果甲硝唑和替硝唑质量浓度分别在2．205-205．24μg／mL和2．002-200．2μg／mL范围内与峰面积线性关系良好,r=1．0000（n=8）,甲硝唑和替硝唑的平均回收率分别为98．80％和98．45％,RSD分别为2．20％和2．46％（n=6）。结论所建立的HPLC法简便易行、准确、重现性好,可同时用于祛痘娄化妆品中甲硝唑和替硝唑两种禁用物质的检测。     

GC测定西地脑中薄荷脑的含量

目的建立气相色谱法测定西地脑中薄荷脑含量的方法。方法在20%PEG-20M色谱柱上,柱温150 ℃, 进样口温度220 ℃,检测器温度230 ℃。结果总薄荷脑平均回收率为99.03%,RSD=0.526%;线性范围0.5～2.5 mg·mL-1。游离薄荷脑平均回收率为98.44%,RSD=1.829%;线性范围0～0.5 mg·mL-1。结论本法简便、快速、准确,可用作西地脑的质量控制。     

Thrombotic thrombocytopenic purpura induced by metronidazole vaginal gel

Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder characterized by microangiopathic hemolytic anemia and thrombocytopenia. Patients with TTP often have an increased reticulocyte count, elevated serum lactate dehydrogenase level, and decreased serum haptoglobin level. Other symptoms include fever, neurologic changes, and renal abnormalities. Thrombotic thrombocytopenic purpura may occur in association with various disorders or conditions, including infections, malignancies, pregnancy, and autoimmune disorders. The disorder may also be drug induced; however, antibiotics are not commonly implicated. A 58-year-old Hispanic woman went to her gynecology clinic and was prescribed metronidazole 0.75% vaginal gel for possible vaginal infection. Three days later, she came to the emergency department with complaints of chest pain and blood in her urine. A complete blood cell count was remarkable for a hemoglobin level of 10.2 g/dl (which decreased to 5.5 g/dl the next day), hematocrit of 29.1% (which decreased to 15.9% the next day), and platelet count of 11 x 10(3)/mm3. Based on these laboratory abnormalities and other clinical findings, the patient was diagnosed with TTP. She was treated with plasmapheresis and corticosteroids and initially responded; however, she relapsed twice, which required increasing the frequency of plasmapheresis, and vincristine and rituximab therapy. The patient's condition resolved, and she experienced no other complications. Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship between the metronidazole vaginal gel and the development of TTP. This patient had developed TTP after only one exposure to metronidazole vaginal gel. Clinicians should be aware of this life-threatening adverse reaction to a commonly prescribed drug.     

甲强复合凝胶治疗牙周炎的疗效观察

为评价甲强复合凝胶治疗牙周炎的临床疗效，选择成人牙周炎患者18例，选择其左右侧对应牙，牙周袋探诊深度≥4mm，进行随机、单盲、对照试验，试验组用甲强复合凝胶，对照组用甲硝唑棒，采用牙周袋局部上药治疗，每天1次，共治疗7天，临床观察牙周袋深度、菌珏指数、牙龈指数、出血指数等指标。结果显示，试验组各临床指标改善均优于对照组。提示甲强复合凝胶治疗牙周炎是有效的。     

鲎试验法检测甲硝唑注射液热原的研究

本文探讨了鲎试验法用于检测甲硝唑注射中热原的可行性。通过检品对鲎试验的干扰验证和鲎实验法与家兔法的对比，结果认为，检品对鲎试验无干扰，该法可代替家兔热原试验，使９０％以上的甲硝唑注射液检品不再进行繁琐而费时的家兔热原检查。     

联立方程组新解法测定痤疮搽剂的含量

本文采用了联立方程组新解法测定座疮搽剂中甲硝唑和氯霉素的含量，测定波长为２７８．０ｎｍ和３２０．０ｎｍ，平均回收率甲硝唑为１００．３％，氯霉素为１００．２％，平均标准偏差甲硝唑为０．２％，氯霉素为０．４％。操作简便快速，方法准确可靠，结果满意。     

下颌阻生第三磨牙拔除术后两种服药方案的临床评价

本文就独一味胶囊加甲硝唑与单独用甲硝唑对下颌阻生牙拔除术后预防伤口出血、感染与促进伤口愈合的作用进行了临床比较研究，结果发现，独一味胶囊加甲硝唑对下颌阻生牙拔除术后伤口愈合的显效率明显高于单独使用甲硝唑（P〈0．005），进而表明，独一味胶囊对下颌阻生牙拔除术后预防伤口出血、感染与促进伤口愈合具有明显的疗效。