新肤螨灵霜治疗酒渣鼻

应用新肤螨灵霜和5％硫磺霜双盲对照试验治疗酒渣鼻64例(男23,女41,年龄40±12a),43例应用新肤螨灵霜,21例应用5％硫磺霜,1月2次,疗程14-20d。新肤螨灵霜的临床治愈率14％,显效49％,有效28％,总有效率91％,明显优于5％硫磺箱(P<0.01)。副作用较轻。因此,新肤螨灵霜值得在临床上试用。     

牙周病人龈沟液中甲硝唑浓度的测定

本文报道了紫外分光光度法测定牙周病人龈沟液中甲硝唑的浓度，具有简便，快速，准确等优点，测定波长为３１９ｎｍ，在２￣２０μｇ／ｍｌ范围内线性关系良好，相关系数ｒ＝０．９９９９，平均回收率为１００．８４％。     

灭滴灵呋喃唑酮治疗慢性溃疡性结肠炎52例临床分析

将灭滴灵与呋喃唑酮联合应用,治疗慢性溃疡性结肠炎52例,设对照组治疗观察,两组的近期疗效分别为96.2％,58.8％,统计学处理,有显著性差异(P<0.01)。作者斟对该病病因及两药联合治疗的机理做了简要分析。     

头孢拉定对甲硝唑血药浓度的影响

目的 :探讨头孢拉定与甲硝唑合并应用时 ,体内甲硝唑血浓度与药动学有否影响。方法 :家兔试验 ,分别给送服甲硝唑 2 0 0 mg,于给药后一定时间分别取血测定。间隔一周后 ,再分别送服甲硝唑 2 0 0 mg+头孢拉定 2 5 0 mg,同样时间取血分别测定血药浓度及药动学参数。结果 :头孢拉定与甲硝唑合用时 ,可使甲硝唑血药浓度升高 ,头孢拉定对甲硝唑药物动力学参数没有影响     

反相高效液相色谱法测定牙周康胶囊中甲硝唑和芬布芬的含量

目的 :建立同时测定牙周康胶囊中甲硝唑和芬布芬的方法。方法 :采用反相高效液相色谱法 ,以Lichrospher ODS(5μm ,4 .0mm× 2 5 0mm)为色谱柱 ,甲醇 水 (75∶2 5 )为流动相 ,检测波长 2 85nm ,峰面积外标法定量。结果 :平均回收率 :甲硝唑为 99.5 % ,RSD 0 .6 % (n =5 ) ;芬布芬为 10 0 .0 % ,RSD 0 .7% (n =5 )。结论 :方法简便 ,快速 ,准确可靠 ,适于该制剂的含量测定。     

甲硝唑含漱剂的体内抗菌作用及临床疗效观察

应用甲硝唑含漱剂药后7天，牙周袋内细菌形态观察，螺旋体和各类杆菌致病菌显著减少，相对球菌随用药时间延长而增多。临床牙周病人观察，牙周指数明显下降，临床症状改善，疗效满意。     

Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8

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葛根芩连汤对动脉粥样硬化伴随牙周炎大鼠的影响

目的:讨论葛根芩连汤对动脉粥样硬化伴随牙周炎大鼠模型的治疗效果。方法:将40只健康雄性Wistar大鼠,分为健康正常组和模型组,正常组10只,模型组30只,正畸结扎丝结扎于左上颌第二恒磨牙牙颈部龈沟内,高脂饮食辅助药物诱导造模,造模成功后分为模型组、甲硝唑治疗组(0.05g·kg-1·d-1)、阿伐他汀组(0.08g·kg-1·d-1)、甲硝唑联合阿伐他汀组、葛根芩连汤组(0.42g·kg-1·d-1),每组6只,ig给予相应药物,4周后,HE染色光镜下观察治疗前后牙周组织和腹主动脉病理变化,检测治疗前后牙周袋深度及附着丧失检测和血脂总胆固醇(TC),甘油三脂(TG),低密度脂蛋白(LDL),高密度脂蛋白(HDL)水平的改变。结果:与正常组比较,模型组牙周袋深度及附着丧失和血脂TC,TG,LDL水平明显升高(P<0.05),HDL明显降低(P<0.05);与模型组比较,甲硝唑组、阿伐他汀组、甲硝唑联合阿伐他汀组、葛根芩连汤组牙周袋深度及附着丧失和血脂TC,TG,LDL水平均较模型组显著降低,差异有统计学意义(P<0.05),HDL明显升高(P<0.05);甲硝唑联合阿伐他汀组与葛根芩连汤组比较牙周袋深度及附着丧失和血脂TC,TG,LDL,HDL水平无差异。HE染色观察发现牙周炎症破坏明显,结合上皮与牙面分离,上皮向根方增殖,组织深部可见大量炎症细胞浸润,骨小梁稀疏,牙槽骨表面可见骨吸收,牙槽嵴顶高度降低,呈垂直吸收,牙周膜纤维粗细不均或断裂,排列紊乱,各给药组均有不同程度的改善,尤其是甲硝唑联合阿伐他汀组与葛根芩连汤组更为明显。结论:葛根芩连汤能够改善模型大鼠牙周炎症水平并且能够降低大鼠血脂水平,提示该药对牙周炎伴动脉粥样硬化疾病有良好的治疗效果。     

Trichomonas vaginalis antimicrobial drug resistance in 6 US cities, STD Surveillance Network, 2009-2010

Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] >50 μg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50-100 μg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed.     

Fermentation in ileostomy bags: Control of excessive gas with diet, pH and antibiotics

The composition of early morning gas from the bags of 10 ileostomates was determined using gas chromatography. Seven of the 10 had a predominance of gases attributable to bacterial fermentation (H₂ and CO₂, 70 ± 12%). The remaining three contained mainly atmospheric gases, N₂ and O₂, with only small amounts of fermentation gases (7 ± 3%).
When a controlled low fibre (0.7 g) dinner was substituted for a high fibre (13.5 g) evening meal, there was a corresponding decrease in the volume of fermentation gas in the ileostomy bag the next morning ( P < 0.05).
Gas production from ileostomy effluent was inhibited in vitro by 10 < pH < 5 and by antimicrobial agents. The most effective were metronidazole, chloramphenicol, tetracycline, erythromycin and chlorhexidine. These reduced fermentation gas by more than 95%.
It was concluded that the majority of the gas produced by ileostomates is formed by bacterial fermentation of the faecal waste in their ileostomy bag and that this may be controlled by careful manipulation of their diet.