卵巢恶性肿瘤与血小板增多关系分析

目的探讨卵巢恶性肿瘤伴发血小板增多的临床规律。方法回顾分析98例卵巢恶性肿瘤患者的临床资料,26例合并血小板增多。结果血小板增多占26.5%,其中晚期(Ⅲ+Ⅳ期)占88.46%,晚期患者血小板偏高明显增多,且肿瘤切除后血小板下降。结论卵巢恶性肿瘤伴发血小板增多晚期患者多见,预后差,血小板增多可作为判断卵巢肿瘤恶性程度及术后随访的指标。     

检测恶性淋巴瘤患者血清可溶性细胞间粘附分子—1的临床意义

目的　通过检测正常人、初治和治疗后完全缓解 ( CR)之恶性淋巴瘤患者血清可溶性细胞间粘附分子 - 1 ( s ICAM- 1 )水平 ,探讨其临床意义。方法　采用酶联免疫吸附法 ( ELISA)检测 2 5例正常人和 2 3例恶性淋巴瘤患者血清 s ICAM- 1含量。结果　初治恶性淋巴瘤患者血清 s ICAM- 1含量高于正常人 ( P <0 .0 1 )和 CR期恶性淋巴瘤患者 ( P <0 .0 5 ) ,而 CR期恶性淋巴瘤患者也高于正常人 ,但无显著性差异 ( P >0 .0 5 )。结论　检测血清 s ICAM- 1的含量对恶性淋巴瘤的诊断、病情观察及疗效判断可能有一定的临床意义。     

Enucleation combined with orbital implants for malignant melanoma of the uvea

Advanced malignant melanomas of the uvea unsuited for an eye salvaging approach require enucleation of the tumor containing eye. A series of 68 patients is reported who underwent enucleation combined with insertion of a spherical dura-encased implant after 30 Gray pre-irridiation therapy of the orbit. Postoperative results with special attention to cosmetic outcome and motility of the prosthesis suggest that the insertion of an orbital implant should be preferred to the enucleation with no implant.     

Four primary malignant tumors, including malignant melanoma and malignant lymphoma, in the same adult patient

We report an 80-year-old Japanese male with four primary malignant tumors: malignant melanoma, prostatic cancer, malignant lymphoma, and renal cell carcinoma, which occurred in that respective order. The combination of malignant melanoma and malignant lymphoma is rare. The patient was treated with BCG after an operation for malignant melanoma. He was also treated with cobalt 60 irradiation after an operation for prostatic cancer. We also discuss other reports of multiple malignant tumors and suggest some possible causes of this patient's primary malignant tumors.     

丝裂霉素胸膜腔灌注治疗肺癌恶性胸膜腔积液初报

目的 观察胸膜腔内灌注丝裂霉素治疗恶性胸膜腔积液的疗效。方法 对15例恶性胸膜腔积液病人采用胸膜腔闭式引流术，1-2d排空胸膜腔积液，后注入100mL生理盐水＋20mg丝裂霉素，夹闭引流管4h后开放，间隔1d再同样方法用1次，引流无液体后拔出引流管，4wk后评价疗效。结果 病人呼吸困难明显好转，生活质量明显改善。CR10例，PR3例，NC2例，总有效率86．7％（13／15）。结论 胸膜腔内灌注丝裂霉素能有效控制恶性胸膜腔积液，对晚期肿瘤所致恶性胸水的病人有重要意义。     

表阿霉素联合化疗方案治疗29例恶性肿瘤疗效观察

目的观察以表阿霉素为主的不同化疗方案对常见恶性肿瘤的疗效及其毒副作用。方法以表阿霉素为主的CEP、CEOP、TE、IEO方案治疗肺癌、非霍奇金淋巴瘤、晚期乳腺癌和横纹肌肉瘤，其中表阿霉素60mg/m^2分2天静脉注射，其他药物都为常规剂量。21～28天为1个治疗周期，治疗2～3个周期后评价疗效。结果全组29例中CR7例，PR13例，SD5例，PD4例，总有效率68．97％。主要不良反应为骨髓抑制，其次是脱发和消化道反应。对肝肾功能和心脏影响轻微。结论以表阿霉素为主的联合化疗方案对常见恶性肿瘤疗效佳，安全性好，患者能较好地耐受。     

恶性肿瘤并发皮肤瘙痒症5例临床分析

作者认为恶性肿瘤引起的瘙痒有二种特点:(1)患者难以忍受;(2)抗组织胺药物无效。     

肿瘤干细胞是中医药防治恶性肿瘤复发转移的可能靶点

肿瘤的复发转移是导致恶性肿瘤治疗失败的主要原因，寻求防治恶性肿瘤复发及转移的靶点是目前肿瘤研究的重点。研究表明肿瘤干细胞在肿瘤的复发转移中扮演着极其重要的角色，目前尚没有靶向调控肿瘤干细胞功能的成熟的方法。中医药在防治恶性肿瘤复发转移中有较好的疗效，为了更好地发挥这种疗效，并深入探讨其作用机制，应对中医药调控肿瘤干细胞功能进行相关研究，找出中医药作用的最终作用靶点。     

腮腺良性和恶性多形性腺瘤的超声研究

目的研究腮腺良性和恶性多形性腺瘤的超声特点,为临床医师诊治提供有效依据。方法选取腮腺良性多形性腺瘤患者79例和恶性多形性腺瘤患者15例,对其肿块的大小、硬度、内部回声、彩色多普勒血流显像(CDFI)特点结合病理学诊断进行对照研究。结果恶性多形性腺瘤的声像图特点与良性多形性腺瘤相似,但其肿瘤相对较大,质地更硬,内部回声分布更紊乱。不同性质的肿瘤的大小和质地有显著性差异,(P<0.01)。结论多形性腺瘤的超声诊断主要依据二维图像之特点。当多形性腺瘤大于3.0 cm,硬度较硬,内部回声分布不均多提示恶性。     

Turcot syndrome confirmed with molecular analysis

Turcot syndrome is clinically characterized by the occurrence of primary brain tumor and colorectal tumor and has, in previous reports, been shown associated with germline mutations in the genes APC , MLH1 , MHS6 , and PMS2 . To date, only few families have been documented by molecular analysis. We report two new families with Turcot syndrome to illustrate and review its characteristics and facilitate diagnosis. Molecular analysis revealed two germline mutations, one in the MLH1 gene and one in MSH2 . The latter has never been describe in the literature. Personal and familial relevant anamnestic data from patients with glioma might aid in the diagnosis of genetic disorders. The subsequent molecular characterization may contribute to the appropriate care of affected patients and asymptomatic gene carriers.