常压及控制性降压下脊髓急性牵拉损伤比较研究

目的 评价控制性降压是否增加脊髓对牵拉损伤的易感性。材料与方法健康成年杂种犬6只，随机分为常压和控制性降压脊髓牵拉损伤组。观察常压及控制性降压水平下相同程度牵拉损伤后脊髓血流(SCBF)、体感诱发电位(SEP)、神经源性运动诱发电位(NMEP)改变的差异。结果 外周血有创动脉压(MABP)平均下降幅度为40．5％。经SSPS统计软件独立样本t检验，不同牵拉水平下，常压组及低压组的SCBF(％)、SEP波幅(Asep)(％)及NMEP波幅(％)无显著差异。结论 尼卡地平控制性降压不增加脊髓对牵拉损伤的易感性。     

左炔诺孕酮宫内节育器的制备及药物释放研究

采用改性乙烯-醋酸乙烯共聚物(mEVA)作为控释材料制备释放左炔诺孕酮(LNG)4μg/d,预期使用寿命为5年的钥匙形宫内节育器(IUD)。本IUD在体外和在人及动物子宫内均为零级释药。释药速度与释药管管壁厚度或管外内径比的对数成反比,提示本释药体系的释药模武符合膜控制释药的特性。动物血药浓度测定结果表明,家兔子宫内植入IUD 2d后,血中LNG浓度趋于稳定。     

患者自控镇痛在妇产科疾病介入治疗中的应用

妇产科疾病介入治疗多采用子宫动脉栓塞（UAE），UAE后即时疼痛发生率为90％～100％，术后疼痛发生率为80％～90％，疼痛可以采用硬膜外患者自控镇痛（patient controlled epidural analgesia，PCEA）治疗。UAE围介入治疗期采用PCEA法镇痛明显优于传统用药法，其间镇痛效果好，不良反应少，能消除或减轻患者的痛苦，提高康复质量；PCEA配方中加入氟哌利多（0．005％）可以减少恶心呕吐不良反应的发生率。     

缺氧对卵巢癌细胞Caov-3转移特性的影响

目的探讨缺氧条件对卵巢癌细胞Caov-3体外黏附和迁移能力的影响。方法在常氧和缺氧条件下培养卵巢癌细胞Caov-3,分别用四甲基偶氮唑蓝(MTT)比色法和细胞迁移试验测定常氧和缺氧条件下培养的Caov-3细胞体外黏附和迁移能力。结果缺氧条件下,Caov-3细胞在Matrigel和纤维连接蛋白Fn基质上黏附数量增加,黏附促进率分别为17.1%和15.2%,与常氧条件下比较有显著性差异(P<0.05)。缺氧条件下,Caov-3细胞在Matrigel基质上迁移距离增大,分别为258.8±19.5μm和331.3±24.4μm,迁移促进率为28.0%,与常氧条件下比较有显著性差异(P<0.05)。结论缺氧环境对卵巢癌细胞Caov-3体外黏附和迁移具有明显的促进作用。     

腹腔镜下良性卵巢囊肿手术50例探讨

目的探讨腹腔镜下卵巢囊肿手术的适应证及手术技巧.方法腹腔镜下行卵巢囊肿剥除术、卵巢-卵巢囊肿切除术和输卵管-卵巢切除术50例.结果卵巢囊肿剥除术46例（92%）,卵巢囊肿切除术2例（4%）,输卵管一卵巢切除术3例（6%）.手术时间30～120min,平均58min.术中出血＜20ml,无中转开腹者,无气栓、出血、感染等严重并发症发生.术后病理诊断：卵巢巧克力囊肿23例（46%）、良性畸胎瘤10例（20%）、卵巢冠囊肿8例（16%）、黄素囊肿5例（10%）、浆液性囊肿3例（6%）、纤维瘤1例（2%）.结论腹腔镜手术治疗良性卵巢囊肿具有微创手术的优点.     

高原地区妇女卵巢激素功能的改变

本文对撒拉、土、回、蒙、藏、汉６种民族２７６６名已婚妇女进行阴道脱落细胞检查。其中对不同民族生育期妇女筛选６００例，ＨＥ·巴氏染色，计数阴道涂片的底层细胞比例，结果提示：卵巢激素功能轻度低落占３８％，中度低落占１４．６６％，高度低落占０．５％，并与地区、民族、年龄分布不同有关。推测高原低氧对卵巢激素功能低落有一定的影响。     

复方18甲基炔诺酮透皮控释传递系统的LNG人体药物动力学与药效学评价

复方18甲基炔诺酮/雌二醇透皮控释传递系统(LNG/E_2 TCDS)能同时恒速释放低剂量的LNG和E_2,在1周内维持一个平稳而有效的LNG血药浓度。药动学与药效学研究证明,该系统释放的LNG能达到血清LNG目标水平,产生有效的排卵抑制(6/6)。LNG/E_2 TCDS可望发展成为一种安全、有效、非侵入性的新型生育调节避孕制剂。     

Conversion of Ouabain-Induced Ventricular Tachycardia in Dogs with Epicardial Lidocaine: Pharmacodynamics and Functional Effects

Epicardial antiarrhythmic drug administration was studied as a therapeutic approach for experimental ventricular tachycardia (VT) in an open-chest dog model. Lidocaine-polyurethane matrices (28%, w/w) were formulated as a model system. Matrices were placed on the left ventricular epicardium in each of 23 anesthetized open-chest dogs with ouabain-induced VT, to evaluate effectiveness in restoring sinus rhythm. Conversion occurred in all animals treated with matrices containing 300 mg or more of lidocaine after 1.5 to 7.0 min. The matrix lidocaine content correlated linearly with the time required for conversion to sinus rhythm (r = 0.75, P = 0.0002); irrespective of matrix size the myocardial/plasma lidocaine ratio was 20.1 ± 4.2 (mean ± SD) at the time of conversion. In a separate series of five dogs without ventricular tachycardia, systolic wall thickening measured with sonomicrometers after 5 min of controlled-release lidocaine administration (500- to 1000-mg matrix lidocaine content, 7.48 ± 3.49-mg/kg dose) was only minimally diminished (–14.1%) and this effect was observed only at the site of matrix placement on the anterior-apical epicardium. In contrast, intracoronary injection of 0.3 or 1.0 mg/kg of lidocaine-HCl resulted in complete elimination of wall thickening or replacement by systolic thinning. Thus epicardial administration of lidocaine from polyurethane matrices was an effective means of treating ouabain-induced ventricular tachycardia. Regional myocardial function in the vicinity of the matrices was modified to a very limited degree, supporting the view that the matrices can be used safely, without serious risk to ventricular contractile performance.