“入营犹可透热转气”发微

透热转气是叶天士在《温热经纬》中首先提出的治疗营分证的方法,对"透热"的适用范围、什么热可透、什么药可透热等作了初步的探讨。     

天花粉对小鼠子宫肥大细胞影响的组织化学研究

目的 研究子宫肥大细胞在给天花粉后的组织化学特性,方法：甲苯胺蓝色染色,Ａｌｃｉａｎ蓝－藏红染色,临界电解质浓度测定和硫酸小蘖碱芝光染色,结果：用天花粉２０小时,２１小时,２２小时,２４小时后,子宫肥大细胞数量均明显增多,增多的肥大细胞ＴＢ染色为浅紫色,ＡＢ－Ｓ染色呈蓝色,硫酸小蘖碱荧光染色不显荧光,临床电解质浓度偏低。结论;增多的肥大细胞首先表现为幼稚的结缔组织型肥大细胞,随天花粉作用时间延长,     

辽宁锦州市居民健康状况与血硒含量相关性的研究

采用新极谱法测定辽宁省锦州市居民的全血硒含量。其中健康人 2 0 0例 ,血硒含量为1 36.5± 47.9μg/ L,男、女各 1 0 0例 ,血硒含量分别为 1 38.5± 46.4μg/ L和 1 34.5± 49.3μg/L。不同血型血硒含量没有明显差异 ( P<0 .1 0 ) ,处于营养状态。患者 338例 ,血硒含量为1 0 2 .2± 38.7μg/ L,男 1 82例、女 1 56例 ,血硒含量分别为 1 0 0 .3± 38.7μg/ L和 1 0 4 .5± 38.6μg/ L,并显著低于健康人血硒含量 ( P<0 .0 0 1 ) ,处于次缺硒状态。不同疾病患者血硒含量大小顺序为呼吸道疾病 >>脑血管疾病≈癌症 >消化道疾病≈心血管疾病 >糖尿病 >眼科疾病     

A Sixty-Year Research and Development of Trichosanthin,a Ribosome-Inactivating Protein

Tian Hua Fen, a herbal powder extract that contains trichosanthin (TCS), was used as an abortifacient in traditional Chinese medicine. In 1972, TCS was purified to alleviate the side effects. Because of its clinical applications, TCS became one of the most active research areas in the 1960s to the 1980s in China. These include obtaining the sequence information in the 1980s and the crystal structure in 1995. The replication block of TCS on human immunodeficiency virus in lymphocytes and macrophages was found in 1989 and started a new chapter of its development. Clinical studies were subsequently conducted. TCS was also found to have the potential for gastric and colorectal cancer treatment. Studies on its mechanism showed TCS acts as an rRNA N-glycosylase (EC 3.2.2.22) by hydrolyzing and depurinating A-4324 in α-sarcin/ricin loop on 28S rRNA of rat ribosome. Its interaction with acidic ribosomal stalk proteins was revealed in 2007, and its trafficking in mammalian cells was elucidated in the 2000s. The adverse drug reactions, such as inducing immune responses, short plasma half-life, and non-specificity, somehow became the obstacles to its usage. Immunotoxins, sequence modification, or coupling with polyethylene glycerol and dextran were developed to improve the pharmacological properties. TCS has nicely shown the scientific basis of traditional Chinese medicine and how its research and development have expanded the knowledge and applications of ribosome-inactivating proteins.     

复方天仙胶囊加联合化疗治疗中晚期食管癌疗效观察

目的：观察复方天仙胶囊加联合化疗治疗中晚期食管瘤的疗效。方法：治疗组35例应用复方天仙胶囊加联合化疗（VBP方案），并与对照组33例联合化疗进行比较。结果：治疗组疗效总缓解率45．7％，对照组33．3％；生活质量Karnafsky计分，治疗组平均提高12分，对照组平均提高4分。结论：复方天仙胶囊加联合化疗治疗中晚期食管癌优于单纯联合化疗。     

付义教授运用“天龙竭”方案联合升陷汤治疗IPF经验撷菁

特发性肺间质纤维化(idiopathic pulmonary fibrosis，IPF)在临床中因其难以控制的症状和纤维化进展，又被称为“慢性癌症”，中医学认为该病属于“肺痿” “肺痹”的范畴。付义教授治疗特发性肺间质纤维化经验丰富，临床治疗归纳总结出该病为“阳虚为本，贯穿始终，痰瘀痹肺为标”的病机特点，治以“补益肺肾、化痰祛瘀、活血通络”的基本原则，运用经验方“天龙竭”方案联合升陷汤辨证加减，临床取得较好疗效。