Self-efficacy estimates for drug use practices predict risk reduction among injection drug users

We used baseline outcome efficacy (OE) estimates for human immunodeficiency virus (HIV) risk reduction to predict subsequent risk reduction 6 months hence among 792 injection drug users in a prospective study. Declines in drug use, frequency of injection, and needle sharing were found among those with high OE scores after adjustment for baseline behavior and antecedent factors. No OE effect was found in multivariate analysis for shooting gallery attendance, a risk that substantially declined in this cohort. OE for needle disinfection was associated with reduced drug risk behaviors, but not for improved needle hygiene practices over time. The self-efficacy model is useful in understanding psychological factors in risk reduction among injection drug users.     

正清风痛宁配合功能锻炼治疗产后腰痛45例分析

目的：分析正清风痛宁配合功能锻炼治疗产后腰痛的疗效。方法：采用正清风痛宁局部注射加腰背功能锻炼的方法治疗。结果：采用JOA评分标准，本组病例优33例，良12例。结论：局部治疗加功能锻炼能有效地恢复下腰部稳定性，取得满意疗效。     

Angiotensin II and its 3–7 fragment improve recognition but not spatial memory in rats

The effects of angiotensin II (AII), its 3–7 fragment [All(3–7)] and the substituted 3–7 fragment [Leu-5,AII(3–7)] given intracerebroventricularly (ICV) at the dose of 1 nmole each, on spatial memory and recognition were tested. AII(3–7) Increased while Lou-5,AII(3–7) slightly decreased session to session foot shock reinforced runtime to the goal in a complex 6 chamber maze. The animals treated with AII performed in the maze similariy to saline injected controls. Overall number of errors was unchanged in all peptide treated groups in comparison with the control group. Object recognition was significantly improved in all the peptide treated groups except for the Lsu-5,AII(3–7) group. The results point to the facilitation of recognition and lack of influence on, or even attenuation of, spatial memory by AII and its 3–7 fragment. Leu-5,Aii(3–7) caused similar though less pronounced effects.     

参麦注射液治疗心力衰竭的临床研究概况

对近年来有关参麦注射液治疗各种病因引起的心力衰竭临床应用研究结果进行概述.     

清肝解毒注射液治疗大鼠实验性急性肝衰竭的研究

目的：研究清肝解毒注射液治疗大鼠急性肝衰竭（ＦＨＦ）的作用。方法：用Ｄ氨基半乳糖（Ｇａｌｎ）造成大鼠实验性ＦＨＦ，观察清肝解毒注射液对其存活率和肝功能的影响，并设肝细胞生长因子（ＨＧＦ）为对照。结果：清肝解毒注射液组（简称清肝组）大鼠存活率为６３．６４％，ＨＧＦ组和模型组分别为５９．０９％和２７．２７％，清肝组存活率明显高于模型组，Ｐ＜０．０５。该药还可降低ＦＨＦ大鼠ＡＬＴ、ＴＢｉｌ水平，提高ＴＣＨ活性，与模型组比较差异显著。结论：清肝解毒注射液对Ｇａｌｎ所致大鼠实验性ＦＨＦ有明显对抗作用     

拉米夫定合用甘草酸二铵治疗慢性乙型肝炎的临床用药研究

目的：单用拉米夫定治疗慢性乙型肝炎肝功能恢复缓慢，较长的炎症期会给肝脏造成慢性损伤，本研究旨在探索较满意的抗病毒-护肝药物联合治疗方案。方法：将90名慢性乙型肝炎患者分为甲、乙、丙三组。每组30例。甲组为联合用药组。乙组为拉米夫定组，丙组为甘草酸二铵组。结果：拉米夫定-甘草酸二铵联合治疗组疗效突出，多个指标与其他两组相比较有显著性差异，基本达到了预期目的。结论：拉米夫定和甘草酸二铵联合应用，既能有效抑制病毒复制，又能缩短炎症期。减少肝脏慢性损伤，是疗效比较理想的治疗方法。     

导管扩张术和活血祛瘀中药治疗输卵管阻塞的临床研究

５０例输卵管阻塞患者首先行输卵管导管扩张术，然后用痛经宝与复方当归液分组治疗，并与西药对比。结果：导管扩张术有效率为９４％；矫正妊娠率：中药组为１００％，西药组为５０％；血液流变学改善，中药组与西药组治疗后比较有显著差异（Ｐ〈０．０１），中药组治疗前后自身比较亦有显著差异（Ｐ〈０．０１）。提示：中药有降低血液粘稠度，防止输卵管再粘连等作用。导管扩张术与中药配合治疗输卵管阻塞是一种新的有效治疗方法。     

制备高效价细菌免疫血清的实验研究

目的：制备高滴度的细菌免疫血清，开展肥达氏反应的教学实验，节约经费，保证教学实验质量的提高。方法：行颅内、脚掌、皮下注射采用弗氏不完全佐剂 死或活细菌，及耳静脉注射途径注射细菌于家兔体内，制备免疫血清，测四种不同注射途径和两种注射法的抗体效价。结果：四种注射途径的效价无差异。结论：耳静脉注射法安全方便，操作易控制，优于其它方法。     

Subcutaneous injection or infusion of gonadotropin releasing-hormone agonist buserelin in the treatment of enlarged uteri harboring leiomyomata

Thirteen women with symptomatic enlarged leiomyomatous uteri completed 6 months treatment with the gonadotropin releasing-hormone agonist (GnRH-a) buserelin, 600 μg daily subcutaneously (s.c.). Seven patients received injections (200 μg thrice daily, I-group) and six infusion by pump (50 μg · min⁻¹ · 2 h⁻¹, P-group). Residual uterine volumes after 6 months therapy were comparable in both study groups (I-group median 37%, range 23 to 74%; P-group median 49%, range 30 to 69%), as were estradiol levels. Symptoms were well controlled within short time. Six months posttreatment follow-up revealed uterine regrowth to pretreatment dimensions in all but 1 patient with recurrence of symptoms in most women. During therapy, several biochemical indices of bone metabolism were significantly elevated, reflecting an increased bone resorption; they were restored within 3 months after cessation of therapy, except for alkaline phosphatase. Triglycerides and HDL-cholesterol did not change during study; cholesterol was slightly, but significantly elevated after 6 months therapy.

GnRH-a buserelin, 600 μg daily by s.c. injection or infusion is equally effective in reducing enlarged leiomyomatous uteri. Discontinuation of therapy is followed by uterine regrowth with recurrence of symptoms in most women. The present mode of therapy seems to be beneficial as an adjunct before myomectomy, or in advancing menopause in symptomatic, climacteric women.