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61.
I.Stanley Anderson Kai-Yiu Yeung Diane Hillman Lawrence S. Lessin 《The American journal of medicine》1975,59(4):568-574
Described here is a case of multiple myeloma in a patient with sickle cell anemia. Viscometric studies were made by comparing the patient's whole blood, plasma and washed red blood cells with those of a normal control subject and a patient with sickle cell anemia. Results showed that the increased viscosity of the patient's whole blood as compared with that of the control patient with sickle cell anemia was mainly due to erythrocytic Interaction with the circulating abnormal immunoglobulin. It is postulated that the increased frequency of vaso-occlusive crisis that occurred in our patient in the months before the diagnosis and treatment of multiple myeloma, was due to this cell-protein interaction with the resulting enhancement of whole blood viscosity and the sickling phenomena. 相似文献
62.
Rahul S. Bhansali Malini Rammohan Paul Lee Anouchka P. Laurent Qiang Wen Praveen Suraneni Bon Ham Yip Yi-Chien Tsai Silvia Jenni Beat Bornhauser Aurlie Siret Corinne Fruit Alexandra Pacheco-Benichou Ethan Harris Thierry Besson Benjamin J. Thompson Young Ah Goo Nobuko Hijiya Maria Vilenchik Shai Izraeli Jean-Pierre Bourquin Sbastien Malinge John D. Crispino 《The Journal of clinical investigation》2021,131(1)
63.
James Reigle Dina Secic Jacek Biesiada Collin Wetzel Behrouz Shamsaei Johnson Chu Yuanwei Zang Xiang Zhang Nicholas J. Talbot Megan E. Bischoff Yongzhen Zhang Charuhas V. Thakar Krishnanath Gaitonde Abhinav Sidana Hai Bui John T. Cunningham Qing Zhang Laura S. Schmidt W. Marston Linehan Mario Medvedovic David R. Plas Julio A. Landero Figueroa Jarek Meller Maria F. Czyzyk-Krzeska 《The Journal of clinical investigation》2021,131(1)
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Daria Capece Daniel DAndrea Federica Begalli Laura Goracci Laura Tornatore James L. Alexander Alessandra Di Veroli Shi-Chi Leow Thamil S. Vaiyapuri James K. Ellis Daniela Verzella Jason Bennett Luca Savino Yue Ma James S. McKenzie Maria Luisa Doria Sam E. Mason Kern Rei Chng Hector C. Keun Gary Frost Vinay Tergaonkar Katarzyna Broniowska Walter Stunkel Zoltan Takats James M. Kinross Gabriele Cruciani Guido Franzoso 《The Journal of clinical investigation》2021,131(11)
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Juan Ramn Tejedor Clara Bueno Meritxell Vinyoles Paolo Petazzi Antonio Agraz-Doblas Isabel Cobo Raúl Torres-Ruiz Gustavo F. Bayn Raúl F. Prez Sara Lpez-Tamargo Francisco Gutierrez-Agüera Pablo Santamarina-Ojeda Manuel Ramírez-Orellana Michela Bardini Giovanni Cazzaniga Paola Ballerini Pauline Schneider Ronald W. Stam Ignacio Varela Mario F. Fraga Agustín F. Fernndez Pablo Menndez 《The Journal of clinical investigation》2021,131(13)
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Hanchen Xu Kevin Van der Jeught Zhuolong Zhou Lu Zhang Tao Yu Yifan Sun Yujing Li Changlin Wan Ka Man So Degang Liu Michael Frieden Yuanzhang Fang Amber L. Mosley Xiaoming He Xinna Zhang George E. Sandusky Yunlong Liu Samy O. Meroueh Chi Zhang Aruna B. Wijeratne Cheng Huang Guang Ji Xiongbin Lu 《The Journal of clinical investigation》2021,131(10)
One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery. In a screen for small-molecule compounds from herbal medicine that potentiate T cell–mediated cytotoxicity, we identified atractylenolide I (ATT-I), which substantially promotes tumor antigen presentation of both human and mouse colorectal cancer (CRC) cells and thereby enhances the cytotoxic response of CD8+ T cells. Cellular thermal shift assay (CETSA) with multiplexed quantitative mass spectrometry identified the proteasome 26S subunit non–ATPase 4 (PSMD4), an essential component of the immunoproteasome complex, as a primary target protein of ATT-I. Binding of ATT-I with PSMD4 augments the antigen-processing activity of immunoproteasome, leading to enhanced MHC-I–mediated antigen presentation on cancer cells. In syngeneic mouse CRC models and human patient–derived CRC organoid models, ATT-I treatment promotes the cytotoxicity of CD8+ T cells and thus profoundly enhances the efficacy of immune checkpoint blockade therapy. Collectively, we show here that targeting the function of immunoproteasome with ATT-I promotes tumor antigen presentation and empowers T cell cytotoxicity, thus elevating the tumor response to immunotherapy. 相似文献