苁蓉总苷对氢化可的松致肾阳虚小鼠学习记忆功能的影响

目的:观察苁蓉总苷对氢化可的松所致肾阳虚模型小鼠学习记忆障碍的影响.方法:连续灌胃给予苁蓉总苷30d,于实验的第11～18天灌胃氢化可的松(正常对照组除外)复制肾阳虚模型,观察记录小鼠的一般状态及死亡情况,使用跳台法观察小鼠的学习记忆功能.结果:(1)苁蓉总苷各剂量组少动、竖毛、少食、少饮、颤抖等阳虚症状均有明显改善,动物死亡数明显减少.(2)苁蓉总苷各剂量组在给予氢化可的松后,各动物的跳台潜伏期明显延长,5min内的错误次数明显减少.结论:苁蓉总苷能明显改善氢化可的松致阳虚小鼠的一般状况及学习记忆功能障碍,并能明显降低小鼠的死亡率.     

肾虚衰老理论研究的新思路

在中医学中,肾虚衰老一直占主导地位,而生命科学研究则表明机体生长、发育与衰老的基础是以细胞周期为核心的细胞增殖、分化与衰老等生命活动,两者之间必然有着某种本质的联系,将肾虚衰老、肾藏精、肾为先天之本理论与细胞基本生命活动之一的"细胞衰老"结合研究,可进一步揭示肾虚衰老理论的本质以及补肾防衰老的分子机制,同时可从另一个角度揭示目前尚未知的中医肾本质,从而深化中医学肾为先天之本理论.     

A Case of Congenital Adrenal Hyperplasia Mimicking Cushing's Syndrome

Congenital adrenal hyperplasia (CAH) is characterized by decreased adrenal hormone production due to enzymatic defects and subsequent rise of adrenocorticotrophic hormone that stimulates the adrenal cortex to become hyperplastic, and sometimes tumorous. As the pathophysiology is basically a defect in the biosynthesis of cortisol, one may not consider CAH in patients with hypercortisolism. We report a case of a 41-yr-old man with a 4 cm-sized left adrenal tumorous lesion mimicking Cushing''s syndrome who was diagnosed with CAH. He had central obesity and acanthosis nigricans involving the axillae together with elevated 24-hr urine cortisol level, supporting the diagnosis of Cushing''s syndrome. However, the 24-hr urine cortisol was suppressed by 95% with the low dose dexamethasone suppression test. CAH was suspected based on the history of precocious puberty, short stature and a profound suppression of cortisol production by dexamethasone. CAH was confirmed by a remarkably increased level of serum 17-hydroxyprogesterone level. Gene mutation analysis revealed a compound heterozygote mutation of CYP21A2 (I173N and R357W).     

保真汤治疗气阴两虚型肺间质纤维化的临床疗效

目的研究保真汤对于治疗气阴两虚型肺间质纤维化的临床疗效。方法选择2017年10月至2020年1月我科门诊收治的34例气阴两虚型肺间质纤维化患者,将受试者分为试验组和对照组,每组各17例。试验组患者采用保真汤加减治疗+常规西医治疗,对照组患者采用常规西医治疗,比较两组患者疗效、治疗前后临床症状积分及预后情况。结果试验组治疗总有效率为94.12%,明显高于对照组的52.94%,差异有统计学意义(P0.05);试验组患者治疗后症状评分较治疗前显著改善,且试验组改善情况明显优于对照组,差异有统计学意义(P0.05);试验组在肺功能FVC降低程度、肺纤维化及蜂窝样变程度(HRCT)、总分得分显著高于对照组,差异有统计学意义(P0.05)。结论保真汤对于气阴两虚型肺间质纤维化患者的临床疗效显著,不仅能有效改善临床症状,同时能够减慢肺纤维化速度,延长患者生命,改善患者生活质量,值得临床上推广及应用。     

NEONATAL PURPURA FULMINANS DUE TO HOMOZYGOUS PROTEIN C DEFICIENCY

Severe and recurrent purpura fulminans developed in a Turkish boy at 1 week of age. Initial coagulation studies performed were compatible with disseminated intravascular coagulation. Subsequent investigations showed that the patient had homozygous and his healthy parents had heterozygous protein C deficiency. The episodes of purpura fulminans were controlled by infusions of fresh frozen plasma and heparinization. Oral anticoagulant therapy was given in the symptom-free period.     

Deficiency of adenosine deaminase 2; special focus on central nervous system imaging

Purpose

To increase the knowledge of central nervous system (CNS) imaging features in deficiency of adenosine deaminase 2 (DADA2) by examining magnetic resonance imaging (MRI) studies of a relatively large number of patients.

Neurogenetics and Clinical Evidence for the Putative Activation of the Brain Reward Circuitry by a Neuroadaptagen: Proposing an Addiction Candidate Gene Panel Map

Abstract

This document presents evidence supporting the role of the KB220/KB220Z neuroadaptagens consisting of amino-acid neurotransmitter precursors and enkephalinase-catecholamine–methyl-transferase (COMT) inhibition therapy called Neuroadaptagen Amino Acid Therapy (NAAT) in brain reward function. It is becoming increasingly clear that this novel formulation is the first neuroadaptagen known to activate the brain reward circuitry. Ongoing research repeatedly confirms the numerous clinical effects that ultimately result in significant benefits for victims having genetic antecedents for all addictive, compulsive and impulsive behaviors. These behaviors are correctly classified under the rubric of “Reward Deficiency Syndrome” (RDS). We are proposing a novel addiction candidate gene map. We present preliminary findings in the United States using qEGG and in China using Functional Magnetic Resonance Imaging (fMRI) regarding the effects of oral NAAT on the activation of brain reward circuitry in victims of SUD. In unpublished data utilizing an fMRI 2X2 design at resting state, NAAT in comparison to placebo shows activation of the caudate brain region and potentially a smoothing out of heroin-induced putamen (a site for emotionality) abnormal connectivity. Although awaiting final analysis, if confirmed by ongoing studies in China coupled with published qEEG results in America, showing an increase in alpha and low beta, NAAT may be shown to impact treatment outcomes.     

Complémentation ou supplémentation en oligo-éléments : qui,pourquoi, comment ?

Trace elements (TE) are essential for biological and physiological functions. They come from food or artificial nutrition. Maintaining or restoring an optimal status is an objective that participates in the nutritional prevention of chronic pathologies. In the hospitalized patient, detecting and fighting deficits will promote faster recovery and reduce infectious complications. In the case of deficient dietary intakes which cannot be corrected by the one nutrition or artificial feeding, the use of suitable trace element supplements is essential. This review presents the main causes and consequences of trace element deficiencies in the general population and in hospital patient, as well as the biological and clinical markers of these deficits. It provides, on the basis of the current recommendations, a practical overview of the conditions for complementation or repletion by oral, enteral or parenteral route, avoiding toxicity with proposals for diagnostic methods and therapeutic interventions.