梯形公式的推广和改进

推广和改进了定积分近似计算的梯形公式。     

高灭灵对蚊,蝇和蟑螂毒杀作用的研究

本文系统地报道了新型杀虫剂高灭灵可湿性粉剂对蚊、蝇和蟑螂的药效。实验室试验结果表明,高灭灵对淡色库蚊幼虫的LC_(50)为0.00092ppm;其对家蝇雌、雄虫的LD_(50)分别为0.000084和0.000039μg/虫:其对德国小蠊雌、雄虫的LD_(50)分别为0.0266和0.0110μg/虫;其对蚊、蝇和蟑螂在三种载体表面具有相当长的残留药效。现场按30mg/m~2处理90天后,对蚊、蝇的RPI值分别为6.1和9.4;KT_(50)分别为19.6和9.8min;上述剂量处理3～30天后,蟑螂密度下降率为100%。     

Antigenicity and allergenicity of cow milk hydrolysates intended for infant feeding

Allergenicity and antigenicity of various commercially available cow milk hydrolysates intended for infant feeding were analysed in 45 children with cow milk allergy. The hydrolysates included the whey hydrolysates Beba HA® (Good Start HA®) and Profylac®, and the casein hydrolysates Alimentum® and Nutramigen®. Positive skin prick tests were recorded against Beba HA in 10 of 41 tested children (24%), against Profylac® in 5/34 (15%) and in one each (2.5%) against Alimentum and Nutramigen. Double-blind placebo-controlled oral challenge tests were performed in 11 children with cow milk allergy using Alimentum, cow milk (positive control) and their regular well-tolerated formula (Nutramigen or soy) used as negative control. One child reacted to Alimentum. This patient was the only one with circulating antibodies against the product, as indicated by a positive RAST. High density SDS-PAGE electrophoresis showed that Beba HA contained a number of unresolved proteins, and non-degraded or partially degraded whey proteins in the range of 5–20 kD. Profylac contained strongly stained protein material in the low molecular weight region 1–10 kD. No protein bands could be identified in the casein-based hydrolysates. Residual antigenicity was tested by measuring the content of betalactoglobulin in the hydrolysates. Three of the hydrolysates contained < 0.06 μg/g dry weight, while the concentration in Beba HA was 200 μg/g dry weight. Positive RAST against Beba HA was detected in 11/45 sera (24%) compared to 7–13% against the other hydrolysates. RAST inhibition with the hydrolysates using cow milk discs was very low for all of them. Using dot immuno-binding assay a weak IgE binding with Alimentum was detected in 4 sera, Beba HA and Profylac in each 2 sera and with Nutramigen in one. The data taken together show that all 4 tested hydrolysates retain some allergenicity. There were differences between the products, one of the whey hydrolysates being substantially more allergenic and antigenic than the other tested formulas. The casein hydrolysate Alimentum showed few reactions in vivo and in vitro in this selected group of children but one child reacted when challenged with Alimentum, indicating that there is a risk for general reactions when using any hydrolysed product in subjects allergic to cow milk.     

烧伤休克延迟快速复苏补液公式的临床研究

目的　探讨烧伤休克延迟快速复苏治疗方案。方法　伤后 4～ 8h后入院的大面积烧伤病人 2 0例 ,分为血浆复苏组和4%琥珀酰明胶复苏组 ,在血流动力学监护下快速补液。监测血流动力学、血液流变学、组织氧合指标和主要脏器功能及损伤指标。结果　快速补液后 2h内输入量加院外补液量占第 1个 2 4h公式计算量的百分比为 48 3 4%,第 1个 2 4h实际输入量较公式计算量多3 1 42 %;快速补液后 ,各观测指标均获改善。结论　根据本研究结果 ,提出延迟快速复苏补液公式和方法如下 :⑴第一个 2 4h预计补液量 (m1) =TBSA( %)×体重 (kg)× 2 6+水分 2 0 0 0mL ,胶体与电解质之比为 1∶1。在血流动力学严密监护下 ,复苏的前 2h将第一个 2 4h液体总量的 1/2快速补入 ;⑵第二个 2 4h预计补液量 (m1) =TBSA ( %)×体重 (kg)× 1+水分 2 0 0 0mL ,胶体与电解质之比为 1∶1。     

西北地区特重烧伤后高钠血症与多器官功能衰竭

研究了西北高海拔干燥地区特重烧伤电解质代谢多器官衰竭的发生原因及相互关系；方法：利用Ｅｖａｎｓ公式指导休克斯复苏补液，观测血清电解质及脑，肺、心等器官功能。结论：认为 高钠血症的原因是同上于Ｅｖａｎｓ公式指导补液的缺陷所致，多器官衰竭与 高钠血症有直接关系。     

泻肾药在补肾剂中的配伍特点探讨

本文结合古医籍中对泻肾药的零星记载,系统地阐述了泻肾药的概念与分类。进而以泻肾药的药性作用特点为依据,通过对补肾常用方的方义分析,17部主要方书中620首补肾方运用泻肾药的统计,分层次地论证了补肾诸方,常配利肾祛湿药;峻补之方,习用利肾化淤药;清补之方,多合清肾泻火药;温补之方,偏伍温肾逐寒药等,是泻肾药在补肾剂中的配伍特点。从而使泻肾药在补肾剂中的配伍运用理论化,系统化,规范化。     

滋肾化毒饮联合环磷酰胺对狼疮性肾炎患者外周血淋巴细胞Fas、FasL、Bcl-2表达的影响及临床疗效观察

目的:观察滋肾化毒饮联合间断性环磷酰胺(CTX)静脉冲击疗法对活动期狼疮性肾炎(LN)患者外周血淋巴细胞(PBL)凋亡调控因子及临床指标的影响.方法:将活动性LN患者40例,随机分为治疗组和对照组,每组各20例.治疗组予滋肾化毒饮联合间断性CTX静脉冲击疗法,对照组予间断性CTX静脉冲击疗法.观察治疗3个月前后的PBL的Fas、FasL、Bcl-2表达及临床指标变化,Fas、FasL、Bcl-2用免疫组化法测定.结果:治疗后两组Fas、FasL及治疗组Bcl-2表达下调(P＜0.05),而Fas、FasL表达下调幅度大于对照组(P＜0.05).治疗组SLEDAI、24 h尿蛋白、Hgb、Ccr、C3指标的改善优于同期对照组(P＜0.05).治疗组肝功能受损、白细胞减少、舌苔厚腻、失眠、痤疮发生率明显少于对照组(P＜0.05).结论:调控Fas、FasL介导的凋亡可能是CTX、激素、滋肾化毒饮有效治疗活动狼疮性肾炎机制之一.     

Treatment for inpatients with anorexia nervosa: Comparison of liquid formula with regular meals for improvement from emaciation

Abstract A new refeeding program using only liquid formula was given to six anorexic inpatients (LF group) at the initial stage of hospitalization. These patients were compared with six other inpatients who regular meals (RM group). The LF group did not develop a phobia of gaining weight, while the RM group showed a vicious cycle of gastrointestinal discomforts leading to fat phobia and stagnation in weight gain. By comparison, the LF group had fewer gastrointestinal symptoms, which resulted in the disruption of this cycle and seemed to help motivate these patients to obtain a steady gain in bodyweight.     

肺癌肿瘤标记物联合检测的信息提示和预测分析

目的:研究肺癌检测指标组合、联检标准和预测模式。 方法:采用蛋白芯片测量技术检测肺癌组和非癌组 12项肿瘤标记物 (TM)粗选指标 ,在此基础上制定组合联检方案 ,并引入数学函数式和构建肿瘤预测图。 结果 :(1)非癌组与肺癌组 12项标记物中糖链抗原 19- 9(CA19- 9)、神经元特异性烯醇化酶 (NSE)、癌胚抗原 (CEA)、糖链抗原 2 4 2 (CA2 4 2 )、癌抗原 12 5 (CA12 5 )、铁蛋白 (Ferritin) 6项测定值差异有统计学意义 (P均 <0 .0 1)。 (2 )非癌组与肺癌组 12项标记物阳性检测实验中 6项指标检测阳性率差异有统计学意义 (P均 <0 .0 1) ,其中肺癌组CEA、CA2 4 2和 CA12 5呈现高阳性检出率 ,结合测定值选择该 3项指标作为联检核心指标。 (3)联检技术参数优于单检技术参数 ,预测阳性率与联检阳性率高度吻合。 结论 :将联合检测与公式判定组合应用 ,对肿瘤的筛选、临床辅诊、疗效判定和随访跟踪具有重要价值     

祛毒化瘀中药复方治疗慢性粒细胞白血病的实验研究

目的了解祛毒化瘀中药复方治疗慢性粒细胞白血病的作用机制。方法采取血清药理学和细胞培养的方法,以K562细胞为研究对象,观察祛毒化瘀中药复方对其的影响。结果祛毒化瘀中药复方具有抑制K562细胞生长,促进K562细胞凋亡,下调特征性的bcr/abl融合基因的mRNA表达的作用。结论祛毒化瘀中药复方具有治疗慢性粒细胞白血病的作用。