防己黄芪汤临床运用举隅

防己黄芪汤临床运用举隅黄泰生（江西省南昌县中医院３３０２００）关键词防己黄芪汤，临床应用，风湿病，汗证，水肿，咳嗽，慢性腹泻，中医药治疗防己黄芪汤出自《金匮要略》，原治风湿在表或风水脉浮身重、汗出恶风之证。笔者根据中医辨证，应用本方加减治疗多种疾病，...     

防己茯苓汤治疗肾病综合征水肿举隅

防己茯苓汤治疗肾病综合征水肿举隅中国中医研究院西苑医院（１０００９１）王芝兰关键词防己茯苓汤，肾病综合征擅××，男，２０岁，１９８４年４月２９日入院，病历号２９０８３。患者于一个半月前扁桃体感染，后出现眼睑浮肿，双下肢可凹性水肿，尿量减少为５００～６...     

张大宁应用防己黄芪汤治疗慢性肾功能衰竭验案举隅

张大宁应用防己黄芪汤治疗慢性肾功能衰竭验案举隅天津市中医医院（３００１４０）刘小玲关键词防已黄芪汤，慢性肾功能衰竭业师张大宁从事肾病研究三十余年，尤对治疗慢性肾功能衰竭见解独到，善用防己黄芪汤。笔者随师临证，获益匪浅，谨呈管见，浅析其验。例一、王××...     

加味防己茯苓汤治疗小儿肾病综合征16例

加味防己茯苓汤治疗小儿肾病综合征１６例保康县欧店镇卫生院（４４１６１３）袁显忠，杜克刚关键词：小儿肾病，中医药疗法小儿肾病综合征临床表现以高度浮肿、大量蛋白尿，高胆固醇血症及低蛋白血症为特征。笔者应用加味防己茯苓汤治疗本病，疗效满意，现介绍如下。１一...     

肝酶谱测定对汉防己甲素抗肝纤维化作用的价值分析

由CCl4诱发的肝纤维化实验大鼠，经汉防己甲素（tetrandrine，Tet）治疗证明：Tet有确实可靠的抗肝纤维化作用。而Tet抗肝纤维化的作用可通过由丙氨酸氨基转移酶（ALT）、胆碱酯酶（ChE）、单胺氧化酶（MAO）、碱性磷酸酶（AKP）、r-谷氨酰转肽酶（r－GT）组成的肝酶谱的活性变化规律加以了解和掌握，因肝酶谱的检测系非介入性检测，较介入性的病理肝组织穿刺检测具有简便、准确、快速并可进行动态观察等优点。     

Tetrandrine and related bis—benzylisoquinoline alkaloids from medicinal herbs：cardiovascular effects and mechanisms of action

Tetrandrine(TET),a bis-benzylisoquinoline alkaloid purified and identified an active ingredient in a Chinese medicinal herb,Radix Stephanae tetrandrae,has been used traditionally for the treatment of congestive circulatory disorder and inflammatory diseases.TET,together with a few of its structural analogues,has long been demonstrated to have antihypertensive action in clinical as well as animal studies.Presumably,the primary anti-hypertensive action of TET is due to its vasodilatory properties.TET prevents or inhibits vascular contraction induced by membrane depolarization with KCl or α-adrenoceptor activation with phenylephrine (PE).TET(30μmol/L) also inhibits the release of endothelium-derived nitric oxide(NO) as well as NO production by inducible NO synthase.TET apparently inhibits multiple Ca^2 entry pathways as demonstrated in cell types lacking the L-type Ca^2 channels.In cardiac muscle cells,TET inhibits both L-and T-type Ca^2 channels.In addition to its actions on cardiovascular tissues,TET may also exert its anti-hypertensive action via a Ca^2 -dependent manner on other tissues intimately involved in the modulation of blood pressure control,such as adrenal grands.In adrenal glomerulosa cells,KCl-or angiotensin II-induced aldosterone synthesis is highly dependent on extracellular Ca^2 .Steroidogenesis and Ca^2 -influx in bovine adrenal glomerulosa cells have been shown to be potently inhibited by TET.In bovine adrenal chromaffin cells,TET inhibits Ca^2 currents via L-and N-type channels as well as other unidentified channels with IC50 of 10μmol/L.Other than the Ca^2 antagonistic effects.TET also interacts with the α-adrenergic receptors and muscarinic receptors based on functional as well as radioligand binding studies.Apart from its functional effects,TET and related compounds also exert effects on tissue structures,such as remodelling of hypertrophied heart and inhibition of angiogenesis,probably by causing apoptotic responses.TET is also known for its anti-inflammatory and anti-fibrogenic actions,which make TET and related compound potentially useful in the treatment of lung silicosis,liver cirrhosis,and rheumatoid arthritis.     

Acute effect of tetrandrine pulmonary targeting microspheres on hypoxic pulmon ary hypertension in rats

目的　评价汉防己甲素 (Tet)肺靶向微球对低氧性肺动脉高压的治疗效应及其对肺循环的选择性作用。方法　 2 0只大鼠经低氧处理 3周 ,另 10只大鼠作为正常对照。对 10只低氧大鼠给予Tet肺靶向微球 ,对 10只低氧大鼠和 10只正常大鼠给予Tet水溶剂。以右心导管法测定大鼠肺动脉平均压 (mPAP) ,经左股动脉插管测定体循环平均压 (mSBP)。结果　低氧后大鼠出现了肺动脉高压。大鼠应用Tet肺靶向微球后 ,其mPAP的降低较Tet水溶剂治疗组更为明显 (P <0 0 5 ) ,且作用持续时间明显延长 ;与Tet水溶剂不同 ,应用Tet微球后大鼠mSBP无显著变化。结论　Tet肺靶向微球对肺循环具有较好的选择性 ,可明显增强Tet降低mPAP的效应。     

防己的临床药效及应用

防己为祛风湿要药,有止痛、利水的功效,目前,全国大多数地区临床中常用的防己在药材名上因其产地的不同有汉防己和木防己之分。汉防己是防己科多年生木质藤本植物粉防己(Stephania tetrandra S.Moore)的根,主产于浙江、安徽、江西、湖北等地;木防己是马兜铃科多年生缠绕草本植物广防己(Aristolochia fangchiWu)的根,主产于广东、广西等地。二者均于秋季采挖,洗净,除去粗皮,晒至半干,切段,个大者再纵切,干燥,切片生用。1临床常见药名1.1防己来源于防己科植物粉防己。别名:粉防己、汉防己、白木香、山乌龟。1.2广防己即马兜铃科植物广防己的…     

汉防己甲素对翼状胬肉成纤维细胞抑制作用的实验研究

目的观察汉防己甲素对体外培养的翼状胬肉成纤维细胞的抑制作用，寻找治疗翼状胬肉和预防其复发的有效药物。方法用MTT比色法测定不同浓度的汉防己甲素对体外培养的翼状胬肉成纤维细胞增生的抑制作用，并与丝裂霉素C（MMC）进行比较；用荧光定量PCR检测10^-5mol／L的汉防己甲素对翼状胬肉成纤维细胞基质金属蛋白酶（MMP）MMP-3 mRNA的表达的影响。结果不同浓度的汉防己甲素对体外培养的翼状胬肉成纤维细胞的增生均有明显的抑制作用（P〈0．01）；10^-5mol／L的汉防己甲素作用24h其MMP-3 mRNA的表达量下降了27．12％。结论汉防己甲素对翼状胬肉成纤维细胞具有明显的抑制作用，可望用于对翼状胬肉的治疗。     

防己黄芪汤水煎液中二种防己生物碱煎出量测定

目的:考察防己黄芪汤水煎煮2种防己生物碱的煎出量.方法:采用薄层扫描法测定生物碱量,稀碘化铋钾显色后测定,测定波长495mm,参比波长600nm.结果:测得防己黄芪汤水煎液中粉防己碱的量为0.69mg/100mL,去甲粉防己碱为0.23 mg/100mL,水煎前防己饮片中粉防己碱为1.39%,去甲粉防己碱为0.57%;防己黄芪汤药材水煎后的防己饮片中粉防己碱为1.26%,去甲粉防己碱为0.26%.结论:防己黄芪汤水煎液中2种生物碱量少,煎出率不高.