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排序方式: 共有4621条查询结果,搜索用时 15 毫秒
41.
《Health & place》2021
Depression is a common comorbidity among Black women with systemic lupus erythematosus (SLE), an understudied autoimmune disease characterized by major racial and gender inequities. Research is needed that examines how area-level factors influence risk of depression in this population. Latent profile analysis revealed four neighborhood typologies among metropolitan Atlanta, Georgia census tracts that participants (n=438) in the Black Women's Experiences Living with Lupus (BeWELL) Study were living in: Integrated/High-SES, Moderately Segregated/Mid-SES, Highly Segregated/Mid-SES, and Highly Segregated/Low-SES. Structural equation models indicated that highly segregated census tracts were associated with the greatest levels of depression via increased subjective assessments of neighborhood disorder. Policies that invest in segregated areas and address physical and social aspects of the environment that contribute to neighborhood disorder may promote mental health among Black women with SLE. 相似文献
42.
《Obesity research & clinical practice》2022,16(2):106-114
BackgroundChildhood obesity places a major burden on global public health. We aimed to identify and characterize potential factors, both individually and jointly, in association with overweight and obesity in Chinese preschool-aged children.MethodsWe cross-sectionally recruited 9501 preschool-aged children from 30 kindergartens in Beijing and Tangshan. Overweight and obesity are defined according to the World Health Organization (WHO), International Obesity Task Force (IOTF), and China criteria.ResultsAfter multivariable adjustment, eating speed, sleep duration, birthweight, and paternal body mass index (BMI) were consistently and significantly associated with childhood overweight and obesity under three growth criteria at a significance level of 5%. Additional fast food intake frequency, maternal BMI, gestational weight gain (GWG) and maternal pre-pregnancy BMI were significant factors for overweight (WHO criteria) and obesity (both IOTF and China criteria). Importantly, there were significant interactions between parental obesity and eating speed for childhood obesity. Finally, for practical reasons, risk nomogram models were constructed for childhood overweight and obesity based on significant factors under each criterion, with good prediction accuracy.ConclusionOur findings indicated a synergistic association of lifestyle, fetal and neonatal, and family-related factors with the risk of experiencing overweight and obesity among preschool-aged children. 相似文献
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目的探究尿源性脓毒症患者T淋巴细胞亚群及辅助性T细胞1(Th1)/Th2细胞亚群细胞因子谱水平变化及其对革兰阳性菌、革兰阴性菌的鉴别价值。方法选择2015年2月-2020年3月遵义医科大学附属医院收治的98例尿源性脓毒症患者、80例常规泌尿系统感染患者及100名查体的健康志愿者作为研究对象,分别纳入脓毒症组、局部感染组、对照组。对脓毒症组患者进行病原菌分析,检测T淋巴细胞亚群比例及白细胞介素-2(IL-2)、IL-4、IL-6、IL-10、肿瘤坏死因子(TNF-α)、干扰素-γ(IFN-γ)等细胞因子水平。结果入组脓毒症患者中,革兰阴性菌引起的尿源性脓毒症患者共53例(检出革兰阴性菌53株),以大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌为主;革兰阳性菌引起的尿源性脓毒症患者共45例(检出革兰阳性菌45株),以表皮葡萄球菌、粪肠球菌、金黄色葡萄球菌、溶血葡萄球菌为主。脓毒症组患者CD3+T淋巴细胞亚群比例、CD4+T淋巴细胞亚群比例、CD4+/CD8+分别为(59.84±7.41)%、(34.84±5.26)%、(1.42±0.65),低于局部感染组、对照组,而IL-2、IL-4、IL-6、IL-10、TNF-α、IFN-γ分别为2.69(0.98,16.23)pg/ml、2.49(0.74,22.74)pg/ml、88.41(10.24,188.52)pg/ml、25.63(1.74,74.15)pg/ml、3.25(1.01,16.96)pg/ml、7.11(1.22,15.63)pg/ml,高于局部感染组、对照组(P<0.05)。革兰阳性菌感染患者CD3+、CD4+、CD4+/CD8+分别为(64.15±4.71)%、(37.41±5.41)%、(1.53±0.34),高于革兰阴性菌感染患者,IL-6、IL-10、TNF-α分别为70.12(15.26,152.37)pg/ml、10.89(2.22,35.96)pg/ml、2.88(1.01,15.27)pg/ml,低于革兰阴性菌感染患者(P<0.05)。CD3+、CD4+、CD4+/CD8+、IL-6、IL-10等指标鉴别革兰阳性菌感染及革兰阴性菌感染的曲线下面积分别为0.651、0.681、0.656、0.769、0.758,当截点值为61.70%、35.10%、1.47、77.41 pg/ml、17.16 pg/ml时约登指数最大。结论尿源性脓毒症患者存在T细胞亚群及Th1/Th2细胞因子谱水平的失衡,且革兰阳性菌及革兰阴性菌脓毒症患者存在一定差异,临床可根据这些指标进行早期诊断及病原菌类型的鉴别。 相似文献
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目的:探讨血脂康的调脂疗效。方法:对84例原发性高脂血症患随机分为血脂康组和烟酸肌醇酯组,。服用血脂康组44例,酸肌醇酯组40例,观察用药8周(wk)后血脂变化,并对二进行比较。结果:显示血脂康有较好的调脂(降TC、TG、TC-HDL-ch/HDL-ch及升HDL-ch)作用,且优于烟酸肌醇酯。结论:提示血脂康调脂职效确切,服用方便,副作用少,可作为较好的临床调脂药物推广使用。 相似文献
48.
目的:研究尿道压力分布图(UPP)对良性前列腺增长(BPH)患者α肾上腺素能受体阻滞剂治疗效果的预测。方法:用改良苄胺唑啉UPP试验将BPH患者分为阳性及阴性组,比较UPP图诸参数之差异。结果:143例BPH患者行改良苄胺唑啉UPP试验,阳性64例,占全部病例(457例)的14.0%。资料完整者阳性组(38例)及阴性组(28例)试验前最在尿流率(Qmax,ml/s)及UPP诸参数无显著性差异(p〈 相似文献
49.
Photoacoustic Fourier transform infrared (PA-FT-IR) depth profiling spectra of the enamel of an intact human tooth are obtained in a completely nondestructive fashion. The compositional and structural changes in the tissue are probed from the enamel surface to a depth of about 200 m. These changes reflect the state of tissue development. The subsurface carbonate gradient in the enamel could be observed over the range of about 10–100 m. The carbonate-to-phosphate ratio increases in the depth profile. The depth profile also reveals changes in the substitutional distribution of carbonate ions. Type A carbonates (hydroxyl substituted) increase relative to type B carbonates (phosphate substituted) with increasing thermal diffusion length. In addition to the changes in the carbonate ion distribution and content, the PA-FT-IR depth profile clearly indicates a dramatic increase in the protein content relative to the phosphate content with increased depth. The changes in the carbonate content and distribution, along with the changes in the protein content, may be responsible for the changes observed in the apatitic structure in the depth profile of the enamel. 相似文献
50.
Hans-Heiner Kramer Michael Sommer Spyros Rammos Otto Krogmann 《European journal of pediatrics》1995,154(9):700-707
This study reports our experience with low-dose prostaglandin E1 (PGE1) treatment of 91 newborns with ductus dependent congenital heart disease (CHD). PGE1 efficacy, side-effects as well as the cardiovascular and respiratory profile of the patients were analysed. PGE1 doses > 0.02 g/kg per minute were used for only 5.3% of the total 23 656 h of treatment. The mean systolic blood pressures did not differ from the normal mean for patients with cyanotic CHD, while the diastolic values were lowered. Respiratory support was required only during 13.7% of the total treatment time. Apnoeas occurred in 21 (38%) of the 55 spontaneously breathing infants, who all had a cyanotic CHD. The incidence of apnoeas was lower during treatment with doses < 0.01 g/kg per minute. 相似文献