小剂量阿斯匹林辅助促排卵过程中对子宫血流及内膜厚度的影响

目的　探讨小剂量阿斯匹林在促排卵过程中对子宫血流及内膜厚度的影响及其作用机理。方法　采用前瞻性随机双盲的方法 ,对不明原因的不孕妇女在克罗米酚 (CC)促排卵治疗同时 ,自月经第 1～ 2 0d连续服用小剂量阿斯匹林 ,75mg/d。 结果　试验组子宫动脉血流阻力指数 (RI)明显低于对照组 (P <0 0 1) ,子宫内膜厚度明显较对照组厚 (P <0 0 5 )。结论　小剂量阿斯匹林可增加子宫血流供应 ,从而改善促排卵治疗时CC所致的子宫内膜发育不良     

Ultrasonography in the detection of cervical incompetency

In 80 pregnancies with clinical and ultrasonic signs of cervical incompetency, the length of the cervix and the thickness of the anterior wall of a lower uterine segment have been evaluated ultrasonically. We have also measured the width of the endocervical canal and studied the prolapse of fetal membranes (with fetal parts) into the endocervical canal. We evaluated these same parameters in 80 healthy pregnancies. The length of the cervix, the thickness of the anterior wall of a lower uterine segment, and the width of the endocervical canal were followed longitudinally in the patients from the 10th to the 36th gestation week. No statistically significant differences between age groups were found. In four age groups at risk for cervical incompetency, cervical lengths and wall thickness were significantly different (p less than 0.001) from those in comparable controls. Forty-five percent of the patients in the at-risk group, with cervical cerclage, delivered at 37.3 (range: 32 to 41) weeks and 6.25% of pregnancies ended in abortion when the amniotic membrane herniated into the cervical canal, with or without some part of the fetus.     

Impaired estrogen-induced uterine insulin-like growth factor-I gene expression in the streptozotocin diabetic rat

Summary Circulating somatomedin-C/insulin-like growth factor-I levels are low in the diabetic rat and unresponsive to exogenous growth hormone. However, the nature of this defect in growth hormone action remains unclear and there is little data on insulin-like growth factor-I gene expression in response to other stimuli and in non-hepatic tissues where insulin-like growth factor-I may have important paracrine and/or autocrine actions. We have previously shown that 17-beta estradiol stimulates uterine insulin-like growth factor-I expression in the ovariectomised rat. In this report uterine and hepatic insulin-like growth factor-I gene expression have been examined in the streptozotocin-diabetic rat. Serum insulin-like growth factor-I concentrations were significantly reduced in diabetic rats compared to normal rats (0.72±0.08 vs 1.23±0.05U/ml, p<0.0005) and hepatic insulin-like growth factor-I mRNA abundance was similarly reduced in diabetic rats to 49±5% of that seen in non-diabetic intact rats (p<0.005). In contrast, uterine insulin-like growth factor-I mRNA abundance was not significantly reduced in diabetic rats compared to control rats (76±12%, p = NS). Although both diabetic and non-diabetic rats demonstrated a significant increase in uterine wet weight following a single injection of 17-beta estradiol the increase in uterine insulinlike growth factor-I expression was significantly less marked in diabetic rats. Acute administration of insulin together with estradiol had no significant effect on serum insulin-like growth factor-I concentrations or hepatic insulin-like growth factor-I mRNA abundance; however, the uterine insulin-like growth factor-I response was significantly (p<0.01) augmented. The observations reported here demonstrate that hepatic insulin-like growth factor-I gene expression is markedly reduced in the diabetic rat and that the estradiol-induced uterine insulin-like growth factor-I response is significantly diminished, consistent with the hypothesis that there is a defect in insulin-like growth factor-I gene activation in the diabetic rat.     

二至天癸颗粒对黄体功能不健性不孕症患者子宫内膜容受性的影响

目的 探讨二至天癸颗粒对黄体功能不健所致不孕症患者的治疗作用及机理.方法 将60例黄体功能不健性不孕症患者随机分为二至天癸颗粒组(试验组)30例和六味地黄颗粒组(对照组)30例,观察两组治疗后中医证候改善情况,黄体中期血清雌二醇(E2)、孕酮(P)水平,黄体中期子宫内膜白血病抑制因子(LIF)表达,以及两组患者的妊娠率.结果 治疗后试验组患者中医证候改善程度优于对照组(P<0.05).试验组黄体中期血清P水平及子宫内膜LIF表达量均明显高于对照组(P<0.05);两组血清E2虽较治疗前有所降低,但差异均无统计学意义(P>0.05).试验组妊娠率亦高于对照组(P<0.05).结论 二至天癸颗粒治疗黄体功能不健性不孕症可能与其提高子宫内膜LIF的表达从而影响子宫内膜容受性有关.     

子宫体三角形切除术的临床应用

目的:探讨子宫体三角形切除术的临床价值。 方法 :对子宫体三角形切除术组、子宫次全切除术组各6 4例进行回顾性分析。结果:两组的手术时间、出血量、术后排气时间等比较 ,差异无统计学意义 (P >0 .0 5 ) ,但子宫体三角形切除术组术后有少量月经。两组在性生活质量及更年期症状方面差异有统计学意义 (P <0 .0 1)。子宫体三角形切除术组的血清性激素水平手术前 FSH(7.0 5± 1.10 ) IU/ L、E2 (5 6 .4 0± 1.12 ) pm ol/ L,手术后 FSH(6 .88± 1.12 ) IU/ L、E2 (5 6 .2 8± 1.15 ) pm ol/ L,手术前后比较差异无统计学意义 (P >0 .0 5 )。子宫次全切除术组血清性激素水平手术前 FSH(5 .98± 1.15 ) IU/ L、E2 (5 6 .2 2± 1.10 ) pmol/ L,手术后 FSH(10 .6 6± 1.18) IU/ L、E2(47.4 5± 1.2 0 ) pmol/ L,手术前后比较差异有统计学意义 (P<0 .0 5 )。 结论:子宫体三角形切除术术式具有操作简单、易于掌握、不影响卵巢功能、术后恢复快等优点 ,能满足患者既去除疾病又保留子宫的生理和心理需要     

中医诊治妇科病的经验

重点论述妇女月经周期的生理变化及施治用药规律,介绍崩漏、痛经、闭经的临床诊治用药经验,有一定的参考价值。     

宫腔镜诊治异常子宫出血432例中长期随访结果

目的 评价宫腔镜手术治疗异常子宫出血的中长期随访结果。方法 回顾分析我院2002年1月～2005年11月经宫腔镜诊治异常子宫出血且随访〉12个月的432例临床资料,诊断良性疾患391例[子宫内膜息肉96例（22.2%）,子宫黏膜下肌瘤38例（8.8%）,子宫内膜增生过长257例（59.5%）],行息肉或肌瘤切除、子宫内膜电切术;诊断子宫内膜腺癌41例（9.5%）,均为Ⅰ期,行经腹全子宫双附件切除、选择性盆腔淋巴结清扫术。结果 手术均获成功,未发生子宫穿孔等并发症。391例良性病变中,术后随访12～57个月,平均39个月,闭经占16.1%（63/391）,月经量少（每周期〈10片卫生巾）18.9%（74/391）,月经量正常（每周期10～20片卫生巾）58.3%（228/391）,术后改善不明显占6.6%（26/391）。26例月经量仍多者术后用孕酮治疗,7例有多发子宫肌瘤,术后32～44个月行全子宫切除术,8例复查阴道彩超子宫内膜厚度〉1.5 cm,术后5～19个月第2次行宫腔镜子宫内膜切除术,继续随访18～36个月,月经量少3例,闭经5例。41例子宫内膜癌Ⅰ期术后随访26～41个月,平均38个月,均无瘤存活。结论 异常子宫出血的治疗在结合病理学检查除外恶性病变后首选宫腔镜手术,严格B超监测是提高手术疗效和手术安全的保障。     

薄层斜轴位T2WI扫描在判断子宫恶性肿瘤宫颈浸润范围中的价值

目的 探讨薄层斜轴位扫描在判断子宫恶性肿瘤宫颈浸润范围中的价值. 资料与方法 回顾性分析53例经手术病理证实的子宫恶性肿瘤患者的MRI资料,比较普通轴位、旁矢状位及薄层斜轴位T2WI 3种扫描方法对判断子宫恶性肿瘤宫颈浸润范围的准确性. 结果 普通轴位、旁矢状位和薄层斜轴位T2WI判断宫颈病变浸润范围的准确性分别为77.36%、60.38%和92.45%.普通轴位与旁矢状位相比（χ2=3.56,P＞0.05）,两者之间差异无统计学意义;薄层斜轴位与旁矢状位比较（χ2=15.13,P＜0.05）,两者之间差异有统计学意义.薄层斜轴位与普通轴位比较（χ2=4.71,P＜0.05）,两者之间差异有统计学意义. 结论 对于宫颈病变浸润程度和范围的准确评价,薄层斜轴位扫描是一种非常必要而且有用的方法,应在常规轴位扫描的基础上加扫薄层斜轴位,提高宫颈病变浸润程度和范围判断的准确性.