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51.
Mohammad Rafiul Haque S. H. Ansari A. K. Najmi Mohammed Afroz Ahmad 《Toxicology mechanisms and methods》2014,24(2):116-123
Context: Obesity has become a worldwide health problem. Most of the synthetic anti-obesity drugs have failed to manage the obesity due to either ineffectiveness or adverse effect. The research of prominent chemical constituents from herbal for the management of obesity has greatly increased.Objective: The main objective of the present study was intended to examine the effects of thymol in high-fat diet (HFD)-induced obesity in murine model.Methods: Male Wistar rats were fed HFD for 6 weeks to induce obesity. Thymol (14?mg/kg) administered orally twice a day to HFD-fed rats for 4 weeks. Alteration in body weight gain, visceral fat-pads weight and serum biochemical markers were assessed.Results: At the end of study, rats fed with HFD exhibited significantly (p?0.001) enhanced body weight gain, visceral pad weight, lipids, alanine aminotransferase (ALT), aspartate aminotransaminase (AST), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), glucose, insulin and leptin levels compared with rats fed with normal diets. Thymol treatment showed significantly (p?0.001) decreased body weight gain, visceral fat-pad weights, lipids, ALT, AST, LDH, BUN, glucose, insulin, and leptin levels in HFD-induced obese rats. Furthermore, thymol treatment showed significantly decreased serum lipid peroxidation and increased antioxidant levels in HFD-induced obese rats.Discussion and conclusions: Thymol prevents HFD-induced obesity in murine model through several mechanisms including attenuation of visceral fat accumulation, lipid lowering action, improvement of insulin and leptin sensitivity and enhanced antioxidant potential. 相似文献
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目的:通过HPLC法测定牛至油注射亚微乳中3种成分(麝香草酚、香荆芥酚、对聚伞花素)的含量。方法:采用Kromasil 100-5 C18 column为分析柱,流动相为乙腈-0.2%磷酸水溶液(54∶46),检测波长274 nm,柱温30℃,流速1.0 mL·min-1。结果:香荆芥酚在0.48~7.2 μg的范围内线性关系良好,线性方程为:Y=319.09X+0.425 1,r2=1;麝香草酚在1.04~15.6 μg的范围内线性关系良好,线性方程为:Y=690.09X+0.353 4,r2=1;对聚伞花素在1.88~28.2 μg的范围内线性关系良好,线性方程为:Y=115.15X-18.037,r2=0.999 9。测得牛至油注射亚微乳中香荆芥酚的含量为1.033 mg·mL-1,麝香草酚的含量为4.561 mg·mL-1,对-聚伞花素的含量为0.185 mg·mL-1。结论:该方法快速、准确、重复性好、分离度高,可同时测定3种成分的含量,可用于牛至油注射亚微乳的质量控制。 相似文献
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Hong Li Tian Yang Fei-Yan Li Yan Yao Zhong-Min Sun 《International journal of clinical and experimental pathology》2014,7(11):7389-7398
The aim of the current research work was to study the chemical composition of the essential oil of Monarda punctata along with evaluating the essential oil and its major components for their antibacterial effects against some frequently encountered respiratory infection causing pathogens. Gas chromatographic mass spectrometric analysis revealed the presence of 13 chemical constituents with thymol (75.2%), p-cymene (6.7%), limonene (5.4), and carvacrol (3.5%) as the major constituents. The oil composition was dominated by the oxygenated monoterpenes. Antibacterial activity of the essential oil and its major constituents (thymol, p-cymene, limonene) was evaluated against Streptococcus pyogenes, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, Haemophilus influenzae and Escherichia coli. The study revealed that the essential oil and its constituents exhibited a broad spectrum and variable degree of antibacterial activity against different strains. Among the tested strains, Streptococcus pyogenes, Escherichia coli and Streptococcus pneumoniae were the most susceptible bacterial strain showing lowest MIC and MBC values. Methicillin-resistant Staphylococcus aureus was the most resistant bacterial strain to the essential oil treatment showing relatively higher MIC and MBC values. Scanning electron microscopy revealed that the essential oil induced potent and dose-dependent membrane damage in S. pyogenes and MRSA bacterial strains. The reactive oxygen species generated by the Monarda punctata essential oil were identified using 2’, 7’-dichlorofluorescein diacetate (DCFDA).This study indicated that the Monarda punctata essential oil to a great extent and thymol to a lower extent triggered a substantial increase in the ROS levels in S. pyogenes bacterial cultures which ultimately cause membrane damage as revealed by SEM results. 相似文献
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目的:建立同时测定无极膏中合成樟脑、薄荷脑、水杨酸甲酯、冰片和麝香草酚5种主要成分含量的分析方法。方法:采用气相色谱法,色谱柱为聚乙二醇(PEG)-20M毛细管色谱柱(30 m×0.32 mm×0.25μm),检测器为FID检测器,进样口温度为250℃,检测器温度为250℃。升温程序为初始温度150℃,保持5 min;10℃.min-1升温至200℃,保持8 min;再以20℃.min-1升温至240℃,保持25 min,分流比为10∶1。结果:合成樟脑、薄荷脑、水杨酸甲酯、冰片和麝香草酚浓度分别在1.4934~7.4672 mg.mL-1(r=0.9999),0.9304~4.6520 mg.mL-1(r=0.9999),0.9075~4.5376 mg.mL-1(r=0.9999),0.1387~0.6936 mg.mL-1(r=0.9999),0.0716~0.3580 mg.mL-1(r=0.9999)质量浓度范围内线性关系良好。平均回收率(n=9)分别为98.8%,99.4%,98.6%,99.6%,99.7%。结论:该方法灵敏、快速简便、准确,可有效地控制无极膏的质量。 相似文献