武当道药治疗风湿性关节炎100例初探

目的 :观察武当道药熏洗液熏蒸冲浪浴治疗风湿性关节炎的临床疗效。方法 :将 2 0 0例风湿性关节炎患者随机分为 3组 ,治疗组用武当道药熏蒸冲浪浴治疗 ,对照 1组用普通水熏蒸冲浪浴治疗 ,对照 2组用武当道药熏洗液浸浴治疗。结果 :总有效率治疗组 91% ,对照组 1组 6 8% ,对照组 2组 78% ,治疗组与对照 1组比较有非常显著性差异 (P<0 .0 1) ,与对照组 2组比较有显著性差异 (P<0 .0 5 ) ,且治疗组的 4项理化检查治疗后转阴率也明显优于两对照组 (P<0 .0 5～ 0 .0 1)。结论 :武当道药熏蒸冲浪浴治疗风湿性关节炎效果明显。     

小肠双重造影对小肠肿瘤的诊断价值

 目的　探讨各种类型小肠肿瘤的小肠造影表现及双重造影的诊断价值。方法　回顾性分析 5 3例小肠肿瘤的双重造影表现。结果　病变 1.0× 1.2cm～ 17× 19cm ,<6cm的病变 2 6例。小肠平滑肌肿瘤主要表现为充盈缺损。小肠淋巴瘤病变范围广 ,主要表现为多发结节状充盈缺损 ,伴肠管狭窄及扩张。小肠腺癌主要表现为肠管不规则狭窄 ,肠壁僵硬破坏 ,显示“果核征”。小肠转移瘤主要表现为多发压迹 ,肠管粘连固定。结论　小肠双重造影是目前诊断小肠肿瘤最有价值的方法之一。     

Morphine-induced suppression of saccharin intake is correlated with elevated corticosterone levels

Rats suppress intake of a saccharin conditioned stimulus (CS) when paired with a drug of abuse. This phenomenon, however, is not uniform across all subjects and is greater following exposure to stress and in animals that more readily self-administer drugs of abuse. The present study was designed to examine these individual differences in intake suppression following seven saccharin-morphine pairings. Plasma corticosterone also was evaluated both before and after conditioning in order to determine whether the magnitude of CS suppression is, or is not, related to circulating corticosterone levels. The findings indicated that, while all rats were exposed to the same number of saccharin-morphine pairings, only half of these animals actually suppressed intake of the saccharin CS. Moreover, the results showed that greater suppression of CS intake was associated with higher corticosterone levels at test (r=-0.84, P<0.0001). Taken together, the results demonstrate that individual differences affect not only the reduction in CS intake following taste-drug pairings, but also the associated cue-induced elevation in circulating corticosterone.     

Dietary hypercholesterolemia aggravates contrast media-induced nephropathy

Background Contrast media administration can result in severe nephrotoxicity under pathological conditions such as diabetic nephropathy, congestive heart failure, dehydration, et al. The purpose of this study was to evaluate the effects of dietary hypercholesterolemia on contrast media-induced changes in renal function, blood flow, and histopathology.Methods Rats were fed either on a normal rodent diet ( group N) or a high-cholesterol supplemented diet ( group H; 4% cholesterol and 1% cholic acid) for 8 weeks. Half of the animals ( n = 6) from each diet group were then given a tail vein injection of 60% diatrizoate (6 ml/kg; group NC and group HC)and the other half were administered saline. Total serum cholesterol, triglyceride, serum creatinine,creatinine clearance rate, fractional excretion of sodium and potassium, and cortical nitric oxide production were determined one day following contrast media administration. Renal blood flow was determined by color Doppler flow imaging and pulsed-mode Doppler. Renal histopathology was observed by light microscopy.Results Total serum cholesterol and resistance indices of renal blood vessels increased significantly,while creatinine clearance rate and production of nitric oxide in the renal cortex decreased markedly in group HC and group H when compared to group N and group NC. The creatinine clearance rate decreased significantly in group HC compared to group H. Serum creatinine levels and fractional excretion of sodium and potassium in group HC were significantly higher than those in the other three groups. Severe tubular degeneration and necrosis, protein cast accumulation, and medullary congestion were found in group HC.Conclusion Hypercholesterolemia is a risk factor for contrast media-induced nephropathy.Hypercholesterolemia aggravates contrast media-induced nephrotoxicity through the reduced production of nitric oxide.     

桡动脉穿刺冠状动脉内介入治疗的临床应用

目的：探讨经桡动脉穿刺选择性冠状动脉造影及冠状动脉腔内成形术（PTCA）及支架术的临床意义。方法：对102例具备冠状动脉造影适应证的患者，采用经桡动脉穿刺法行右、左冠状动脉造影，并根据冠状动脉造影结果决定是否行经皮冠状动脉腔内成形术（PTCA）及支架术。结果：冠状动脉狭窄（50-70）％21例（21／102，占21％），〉75％以上68例（68／102，占67％），68例行PTCA及支架植入术，〈50％13例（13／102，占12％），冠状动脉正常25例（25／70，占35．5％）。结论：通过冠状动脉造影，可以定性诊断，指导治疗；桡动脉穿刺具有出血并发症少等优点。     

肾脏错构瘤超声造影动态特性分析

目的研究对比脉冲序列造影成像技术（CPS）在肾脏错构瘤造影成像中的价值。方法对24例肾脏错构瘤患者（28个病灶）进行超声造影观察．分析其造影增强的图像特点。结果28个病灶均获得清晰的肿瘤动态造影灌注图像。肾脏错构瘤的造影特点表现多样，造影征象与肿瘤大小相关．小肿瘤（直径〈2cm）多表现为掩盖样快速强化，直径≥2cm的肿瘤多表现为慢速填充的造影征象。结论CPS清晰显示了肾脏错构瘤的血流灌注形态学特点，对≥2cm的肾脏错构瘤更能清晰显示其微循环灌注特点，有助于诊断和鉴别诊断。     

3种蟑螂密度监测方法与效果分析对比试验

目的验证3种蟑螂密度监测方法之间的实效性、可比性,为蟑螂密度调查提供科学依据.方法采用目前常用的3种蟑螂密度监测方法,在同一现场同步进行对比试验.结果目测法、粘捕法、药激法蟑螂密度检出率分别为19.32%,11.26%,5.86%.3种监测方法结果比较,x2=37.72,P<0.001,差异有显著性意义,其中目测法检出率最高.结论应当结合实际,采用因时、因地制宜的科学监测方法,提高灭蟑效果.     

高血压部分危险因素及分层在性别间的对比分析

目的 调研金昌地区高血压人群中高血压危险分层在性别间的差异，为合理防治提供依据。方法 对高血压科研课题中的高血压患者进一步追踪调研，针对密切相关的生活嗜好、并发症、辅助检查结果．危险分层，分年龄段男女间进行对比分析、探讨其特殊规律。结果 男性高血压患者中吸烟、饮酒、高脂餐以及高血压脑病、脑血栓、肾损害者居多，危险分层以高危者居多；女性高血压患者中心绞痛、房室早博、尿糖阳性者较多，危险分层中以低危害者居多。结论 各年龄段性别间，高血压部分危险因素及分层差异显著，应分年龄段合理防治。     

三焦点与单焦点人工晶状体植入术效果的比较

目的：观察并比较AT LISA tri 839MP三焦点人工晶状体及CT SPHERIS 209M单焦点人工晶状体植入术后白内障患者的视力、对比敏感度和视觉质量。

方法：行白内障超声乳化摘除联合人工晶状体植入术的患者52例52眼,其中三焦点组26例26眼,术中植入AT LISA tri 839MP三焦点人工晶状体; 单焦点组26例26眼,术中植入CT SPHERIS 209M单焦点人工晶状体。术后3mo检查患者的裸眼远距离视力(UCDVA)、裸眼中距离视力(UCIVA)、裸眼近距离视力(UCNVA)、最佳矫正远视力(BCDVA)、远视力矫正下的中距离视力(DCIVA)、远视力矫正下的近距离视力(DCNVA),明、暗环境中不同空间频率(3、6、12、18c/d)下的对比敏感度,并进行脱镜率、不良视觉症状和满意度等问卷调查。

结果：术后3mo三焦点组UCIVA、UCNVA、DCIVA和DCNVA、脱镜率及满意度均优于单焦点组(P<0.05)。在暗环境中的18c/d空间频率,单焦点组的对比敏感度优于三焦点组(P=0.041)。两组均有轻度眩光和光晕不适主诉(P=0.668)。

结论：AT LISA tri 839MP三焦点人工晶状体较CT SPHERIS 209M单焦点人工晶状体为患者提供了更好的中、近视力,脱镜率和满意度均高于单焦点人工晶状体。     

Comparison of contrast sensitivity based on the surgical results for intermittent exotropia

AIM: To compare contrast sensitivity (CS) based on the surgical results for intermittent exotropia (IXT) and to examine the relationship between CS and photophobia. METHODS: Medical records of the patients who underwent bilateral lateral rectus muscle recession for IXT between 4 and 12 years old were reviewed retrospectively. They were categorized based on the surgical results; successful correction group (n=36) and overcorrection group (esotropia ≥10 PD at 3mo postoperatively, n=18). Using CGT-2000 test for CS was performed binocularly, and subjective reports of photophobia was investigated preoperatively and at 3mo postoperatively. Objective photophobia was defined as a significant decrease in CS in the presence of glare. RESULTS: Preoperatively, there was no difference in CS between the groups. Postoperatively, under mesopic conditions, significant improvement of CS was observed at 6.3°, 4°, and 2.5° in the successful correction group and at 6.3° and 4° in the overcorrection group, regardless of glare. Under photopic conditions, at all visual angles except 0.64°, improvement in CS was noted in both groups while CS worsened significantly at 0.64° in the overcorrection group postoperatively. At all visual angles under photopic conditions postoperatively, regardless of glare, CS in the overcorrected group was significantly worse than that in the successful correction group, and CS was significantly decreased by addition of glare in both groups. All patients except one (96.4%) in the successful correction group and 8 patients (61.5%) in overcorrection group showed improvement of photophobia postoperatively, which correlated with CS under photopic conditions (P=0.001, 0.03). CONCLUSION: After surgery for IXT, CS under photopic conditions improve at all visual angles except 0.64°, while CS is significantly worse in the overcorrection group postoperatively at 0.64°. Subjective photophobia have significant correlation with CS under photopic conditions, and may be used as an objective indicator of photophobia.