寻常痤疮发病机制相关信号通路的研究进展

寻常痤疮是一种毛囊皮脂腺单位的炎症疾病,在青少年中的发病率高达85%,发病机制与雄激素、皮脂分泌、嗜脂性微生物感染、免疫-炎症反应等密切相关。本文从炎症信号通路、皮脂分泌通路方面,综述与痤疮相关的信号转导通路。     

毫火针联合中药药膜外敷治疗轻中度痤疮疗效观察

目的:探讨毫火针联合中药药膜外敷治疗轻中度痤疮患者的临床效果和安全性。方法:将100例门诊确诊为轻中度痤疮的患者随机分成两组。治疗组:50例,使用毫火针配合中药药膜外敷治疗(每周2次,8周为1个疗程);对照组:50例,仅采用毫火针治疗(每周2次,8周为1个疗程),治疗1个疗程后观察两组的治疗效果及安全性。结果:治疗组:治愈6例,显效19例,有效22例,总有效率94.0%;对照组:治愈3例,显效12例,有效25例,总有效率80.0%,两组疗效比较差异有统计学意义(P<0.05)。治疗后,治疗组患者DLQI积分为2.52±0.81,显著低于对照组,差异具有统计学意义(P<0.05);治疗后,治疗组患者的DLQI积分下降幅度显著高于对照组,差异具有统计学意义(P<0.05)。治疗期间,治疗组发生不良反应1例,发生率为2%;对照组未发现明显不良反应,差异无统计学意义(P>0.05)。结论:毫火针联合中药药膜外敷治疗轻中度痤疮安全、有效。     

磺胺嘧啶银脂质水胶体对颜面部重度融合性痤疮的治疗效果观察邵利萍 黄媛媛 吴唯勤(通讯作者)

【】目的探讨磺胺嘧啶银脂质水胶体治疗重度颜面部痤疮的临床疗效,为后期临床推广应用提供参考资料。方法使用Pill Sburv及国际改良痤疮分级法进行分级,选择评级为IV级的重度痤疮共计40例,随机分为实验组与对照组,实验组磺胺嘧啶银脂质水胶体联合马齿苋,对照组使用维甲酸联合马齿苋治疗,随访患者后期疗效、炎症因素TNFα和IL-4水平及不良反应,使用SAS 9.1进行统计分析。结果实验组的治疗效果要明显优于对照组( ₂=8.076,P=0.004)；实验组治疗前两组在TNF-α、IL-4差异无明显统计学意义(p>0.05),治疗后第4周、第8周结果显示实验组的TNF-α、IL-4含量要明显低于对照组,差异有统计学意义；两组不良反应发生率上,两组差异无明显统计学意义。结论目前磺胺嘧啶银脂质水胶体用于重度痤疮研究较少,联合马齿苋清理创面研究也少,本研究结果显示磺胺嘧啶银脂质水胶体联合马齿苋应用于重度颜面部痤疮治疗效果显著,可以加以推广应用。     

Heredity of acne in Korean patients

Acne is a chronic inflammatory disease of the pilocebaceous unit that presents with various spectrum and severity. Genetic backgrounds and environmental factors are also considered to be relevant, but few studies have focused on Korean patients. A cross‐sectional epidemiologic study on family history of Korean acne patients was performed to analyze family history of acne, and to compare the severity and characteristics of acne in association with family history. A total of 221 patients were enrolled, 98 male (44.3%) and 123 female (55.7%). Patients were grouped as patients with (A+) or without (A‐) family history of acne. In a second analysis, patients with any experience of acne treatment were evaluated. Severity of acne was measured with Burton's grading system and Korean Acne Grading System (KAGS). Female patients had a higher tendency to have family history than males (P = 0.002). Group A+ had statistically significant earlier onset of acne (P = 0.002). In inexperienced patients, patients with family history showed a relatively earlier onset (P = 0.084). This study confirmed the role of heredity in acne. Family history of acne is associated with earlier onset of the disease, and more non‐inflammatory lesions.     

基于UPLC-Q-TOF-MSn的化妆品中40种性激素非法添加分析方法及筛查数据库的建立

目的 建立基于UPLC-Q-TOF-MSⁿ的化妆品中40种性激素非法添加分析方法及筛查数据库。方法 色谱柱为Agilent SB-C₁₈(2.1 mm×50 mm，1.8 μm)，正离子模式以0.1%甲酸水溶液-乙腈为流动相，负离子模式以水-乙腈为流动相，梯度洗脱，流速0.2 mL·min^-1，柱温35 ℃；采用电喷雾电离源(ESI)，采集模式为Scan MS及Targeted MS/MS，将40种性激素的精确质量数、保留时间、二级质谱图导入PCDL软件建立筛查数据库。结果 采用所建立的数据库方法快速筛查100批化妆品，1批育发类产品检出少量黄体酮。结论 本研究所建立的40种性激素分析方法和筛查数据库具有简便、快速、灵敏和准确的特点，适合化妆品中非法添加性激素的高通量筛查和准确定性。     

抗雄激素药物联合应用治疗女性中重度迟发型痤疮的临床疗效评价

目的：探讨抗雄激素药物联合应用治疗女性中重度迟发型痤疮的最佳方案和疗效。方法：将112例患者按完全随机设计法分成三组：治疗Ⅰ组采用达英-35联合小剂量甲泼尼龙口服,治疗Ⅱ组采用螺内酯联合小剂量甲泼尼龙口服,对照组采用维胺酯口服,4周为1个疗程,连续治疗12周后观察疗效及不良反应,治疗前后检测三组患者血清睾酮（T）、雌二醇（E2）。结果：12周后,治疗Ⅰ组有效率为73.7%,与对照组比较差异无统计学意义（P〉0.05）;治疗Ⅱ组有效率为41.2%,与对照组比较差异有统计学意义（P〈0.05）;治疗Ⅰ、Ⅱ组治疗前后血清T差异有统计学意义（P〈0.05）,E2差异无统计学意义（P〉0.05）;对照组治疗前后T、E2差异均无统计学意义（P〉0.05）。结论：达英-35联合小剂量甲泼尼龙可有效治疗女性迟发型中重度痤疮。     

The analysis of acne increasing suicide risk

Acne is associated with depression and anxiety; however, the relationship between acne and suicide is still unclear. This study is aimed to evaluate the association between acne and suicide by conducting a meta-analysis. Studies were identified by electronic searches of the PubMed and EMBASE databases from their inception through Jan 10, 2020. Two authors separately assessed the quality and extracted data from the selected studies. When the heterogeneity was significant, we used a random-effects model to calculate overall pooled risk estimates.Five studies involving a total of 2,276,798 participants were finally included in the meta-analysis; 52,075 participants had acne. Suicide was positively associated with acne in the overall analysis (odds ratio (OR) 1.50, 95% confidence interval (95% CI): 1.09–2.06, P = .004, I² = 74.1%). Subgroup analyses were performed for suicidal behavior groups (P = .002, I² = 80.4%), suicidal ideation or thoughts groups (P = .849, I² = 0.0%), International Classification of Diseases version 9 (ICD-9) groups (P = .137, I² = 49.6%), non-ICD-9 groups (P = .950, I² = 0.0%), American groups (P = .311, I² = 2.4%), and non-American groups (P = .943, I² = 0.0%). Sensitivity analyses indicated flawed results. No publication bias was detected.Acne may significantly increase suicide risk. Clinicians should actively treat acne and consider suicide screening. Further international studies with high-quality analyses are needed as more data are published.Ethical approval and patient consent are not required because this study is a literature-based study.