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41.
M. E. Perry Y. Mustafa S. K. Wood M. I. D. Cawley D. C. Dumonde K. A. Brown 《Rheumatology international》1997,17(4):169-174
A morphological examination of synovial tissue from 25 patients with rheumatoid arthritis revealed that binucleated or multinucleated
plasma cells were present in all samples and absent in synovia obtained from 16 control patients. Plasma cells containing
two, three of four nuclei constitutet a mean 3% of the total plasma cell population. They were aways found amongst plasma
cell infiltrates and in close association with small blood vessels. Ultrastructural analysis found no evidence of cellular
membranes separating the individual nuclei in binucleated or multinucleated plasma cells, suggesting that the cells did not
arise from fusion. Some of these plasma cells had a diameter approaching 100 μm, and many were in intimate contact with macrophages.
The demonstration of a few cells with mitotic figures within the infiltrates suggests that the maintenance of plasma cell
numbers in rheumatoid synovium may depend, in part, upon their local proliferation.
Received: 25 August 1997 / Accepted: 2 October 1997 相似文献
42.
免疫抑制因子对佐剂关节炎的影响 总被引:1,自引:0,他引:1
目的;研究免疫抑制因子对佐剂关节炎发病的影响。方法:检测对照组与实验组对正常小鼠淋巴细胞转化的影响。结果:脑室注射IL1的关节炎大鼠在第0、7、14、28、35d的血清具有明显的抑制淋巴细胞转移化的作用。关节炎症状加重,病程延长。结论:免疫抑制蛋白可能参与佐剂关节炎的发病,有可能是造成关节炎的原因之一。 相似文献
43.
High levels of the soluble form of CD30 molecule in rheumatoid arthritis (RA) are expression of CD30+ T cell involvement in the inflamed joints. 总被引:2,自引:0,他引:2 下载免费PDF全文
R Gerli C Muscat O Bistoni B Falini C Tomassini E Agea R Tognellini P Biagini A Bertotto 《Clinical and experimental immunology》1995,102(3):547-550
The CD30 is a surface molecule expressed by Th2-type lymphokine-producing T cells upon activation. CD30-expressing activated T cells release a soluble form of the molecule, which can be detectable both in vitro and in vivo. In the present study, high levels of soluble CD30 were found in peripheral blood and synovial fluid from patients with RA. However, CD30+ CD3+ cells, either CD4+ or CD8+, were significantly present in synovial fluid, but not in peripheral blood, of RA patients. Serum values of soluble CD30 were higher in active than inactive RA patients and directly correlated with rheumatoid factor serum titres. These data strongly support an involvement of CD30+ T cells in the immune processes of rheumatoid synovitis, and may suggest a relationship between Th2-type cytokine-secreting T cells and the pathological response in RA. 相似文献
44.
U. Meyding-Lamadé K. Rieke D. Krieger W. Hacke Michael Forsting Klaus Sartor Christian Sommer 《Journal of neurology》1995,242(5):335-343
Acute ischaemia of the vertebrobasilar circulation leads to a variety of clinical manifestation and is mostly due to cardiogenic or artery-to-artery embolism. We describe four neurological emergency situations involving vertebrobasilar artery aclusion of other origins: basilar migraine, extrinsic compression by rheumatoid inflammatory tissue, generalized vasculitis in subacute rheumatic fever and basilar artery dissection. The differential diagnosis of acute vertebrobasilar artery occlusion may have an important impact on patient management. 相似文献
45.
类风湿关节炎90例(男性18例,女性72例,年龄47±s12a),随机分为芍药总甙(TGP)60例,1.8g/d,分3次po,甲氨喋呤(MTX)每同po1次15mg,2药均4wk为一个疗程,连用3个疗程。服药的wk4,8,12,TGP的总有效率分别为45%,60%和63%,MTX的总有效率分别为53%,67%和70%,2组相比无显著差异(P>0.05)。TGP的不良反应(28%)低于MTX(57%)。 相似文献
46.
Jalil Tavakkol AFSHARI Zahra REZAIEYAZDI Farnaz SHOJA‐TAHERI Majid SADEGHIZADEH 《International journal of rheumatic diseases》2007,10(3):209-213
Aim: Rheumatoid arthritis (RA) is the most common chronic inflammatory erosive joint disease with the worldwide distribution of approximately 0.5–1.0%. Etiology of RA is not exactly known but immunologic and genetic factors play an important role in the pathogenesis of the disease. Genetic factors such as human leukocyte antigens (HLA) are responsible for many autoimmune diseases; therefore we decided to look for a correlation between RA and the presence of HLA‐DQβ1 alleles as possible genetic markers. Methods: Genomic DNA from the whole blood samples of 25 patients with RA and 86 normal individuals as control group were extracted by salting out method. The genomic DNA was amplified by polymerase chain reaction‐sequence specific primer (PCR‐SSP) technique. HLA‐typing was done by this method after optimizing the PCR reaction for each allele. In this procedure seven serological subclasses of HLA‐DQβ1 can be detected. Results: Comparing the results between the patients and controls show a significant increase in the frequency of HLA‐DQ8 (*0302, *0305) alleles in RA patients. The P‐values were 0.007 and the relative risk for these alleles was evaluated higher than 1. Conclusions: The results suggest that DQ8 is the dominant HLA‐DQβ1 allele that is associated with susceptibility to RA in north‐eastern Iran. 相似文献
47.
MC Brouard P Chavaz L Borradori 《Journal of the European Academy of Dermatology and Venereology》2004,18(1):89-92
BACKGROUND: Bowel-associated dermatosis-arthritis syndrome denotes the occurrence of diarrhoea with arthritis and skin lesions related to bowel disease with or without bowel bypass. In this condition, the histological finding of cutaneous aseptic neutrophilic cell infiltrate is non-specific and common to a wide spectrum of neutrophilic dermatoses, including pyoderma gangrenosum. OBSERVATION: We describe a 78-year-old woman with fever, abdominal discomfort and arthralgias, who developed grouped pustular lesions on her shins with histologically spongiform pustule formation. Aetiological assessment disclosed diverticular disease with sigmoid stenosis. CONCLUSION: Although clinical and histological features in our case fit the diagnosis of bowel-associated dermatosis-arthritis syndrome, they may also correspond to a pustular variant of pyoderma gangrenosum. Our observation raises the question of the nosological classification of bowel-associated dermatosis-arthritis syndrome within the spectrum of neutrophilic diseases. 相似文献
48.
Chieko Nakamura Yoshiharu Kawaguchi Hirokazu Ishihara Hiroshi Sainoh Tomoatsu Kimura 《Journal of orthopaedic science》2004,9(6):629-634
We report two cases of rheumatoid arthritis (RA) with upper thoracic myelopathy and a review of the literature. Clinical data of a 47-year-old woman (case 1) and a 54-year-old woman (case 2) are described. Case 1 showed a transverse-type myelopathy at the T2 segment level of the spinal cord and case 2 had the same type of myelopathy at the T4 segment level. Case 1 had anterior vertebral subluxation of C7 due to marked vertebral collapse and Case 2 had subluxation of T2 with vertebral destruction. These two patients had the mutilating type of RA with multilevel spontaneous fusion in the cervical spine. The lesions in the thoracic spine might be caused by the severe destructive inflammation that is characteristic in mutilating disease. The vertebral collapse might lead to subluxation of the upper thoracic vertebra, resulting in spinal cord compression. Upper thoracic subluxation might be caused by vertebral collapse due to RA and the increased motion as a compensation for decreased mobility caused by spontaneous fusion in the cervical spine. 相似文献
49.
激光穴位点射疗法对痛风急性期的疗效观察 总被引:9,自引:0,他引:9
杨惠琴 《中国中医骨伤科杂志》2006,14(1):18-20
目的:观察500MW激光风湿治疗机穴位点射治疗痛风急性期的疗效,探讨其作用原理。方法:痛风急性期患者48例,随机分为激光组和对照组,每组24例。激光组用输出波长为810 NM,功率为500 MW激光风湿治疗机,通过穴位点射方法治疗。对照组口服非甾体类消炎药。疗程均为3~7 d,观察患者关节疼痛肿胀情况及不良反应表现。结果:激光组疗效优于对照组,且毒副作用明显小于对照组。结论:激光穴位点射治疗对痛风急性期有良好的治疗作用,且无明显不良反应,患者依从性好。 相似文献
50.