Comparative Aesthetic Evaluation of Lip Reconstruction Using Abbe’s Flap in Secondary Cleft Lip Deformities: A Retrospective Study

AimTo objectively evaluate the surgical outcome of deformed cleft lip treated by Abbe’s flap using Digimizer image analysis software.MethodsFifteen Abbe’s flap (AF) reconstruction cases with satisfactory photographic records were acquired in Digimizer image analysis software. Anthropometric landmarks were marked on the lip. Bilateral lip lengths, height and width were measured preoperatively and postoperatively after AF reconstruction for comparison.ResultsIt was observed that by AF reconstruction, we could increase vermillion lip length and Cupid’s bow width, hence providing adequate bulk to the middle of the lip. In addition to it, in some cases we could achieve the acceptable anatomy of the centre of the Cupid’s bow with which it was sometimes disturbed during primary cheiloplasty. Lip length and lip height became proportionately equal bilaterally, leading to adequate lip symmetry in all cases.ConclusionComputer-assisted anthropometric analysis of photographs using Digimizer image analysis software (MedCalc Software, Belgium) demonstrates that AF lip reconstruction technique produces aesthetic lip consistently.     

2种不同形变配准软件在头颈部勾画中的作用评价

目的 比较2种目前放疗市场上主流的形变配准软件在CT形变配准中的结果表现,确定其在图像配准中的价值。方法 选择本院2018年2月—2020年6月收治的15例重复定位的头颈部肿瘤患者作为研究对象,治疗过程中前、后2组CT图像正常组织由同一位资深医师进行勾画,分别在MIM软件和AccuContour软件中进行形变配准,将第一组图像的正常组织形变到第二组图像中,与第二组图像直接勾画的组织进行计算,得到相似性系数（Dice系数）与空间评价指标（Hausdorff距离）。采用SPSS 23.0软件包对数据进行统计学分析。结果 2种形变配准软件都有良好的形变配准功能。正常组织显像不同,对配准结果有一定影响,眼球、下颌骨等显像良好的组织配准结果更好,晶体、视神经、视交叉等小体积组织配准结果较差。2组软件相比,MIM软件更具有优势;Dice系数评价中,MIM软件数据更佳的比率为67%,其中55%存在统计学意义（P<0.05）;Hausdorff距离显示,MIM软件数据更佳的比率为74%,其中48%的指标存在统计学意义（P<0.05）。结论 2种形变配准软件都具备良好的形变配准能力,相对而言,MIM软件更有优势。对形变配准精度要求较高时,选择MIM软件更佳。     

A Lot of Action,But Not in the Right Direction: Systematic Review and Content Analysis of Smartphone Applications for the Prevention,Detection, and Management of Cancer

Background

Mobile phones have become nearly ubiquitous, offering a promising means to deliver health interventions. However, little is known about smartphone applications (apps) for cancer.

Objective

The purpose of this study was to characterize the purpose and content of cancer-focused smartphone apps available for use by the general public and the evidence on their utility or effectiveness.

Methods

We conducted a systematic review of the official application stores for the four major smartphone platforms: iPhone, Android, Nokia, and BlackBerry. Apps were included in the review if they were focused on cancer and available for use by the general public. This was complemented by a systematic review of literature from MEDLINE, Embase, and the Cochrane Library to identify evaluations of cancer-related smartphone apps.

Results

A total of 295 apps from the smartphone app stores met the inclusion criteria. The majority of apps targeted breast cancer (46.8%, 138/295) or cancer in general (28.5%, 84/295). The reported app purpose was predominantly to raise awareness about cancer (32.2%, 95/295) or to provide educational information about cancer (26.4%, 78/295), followed by apps to support fundraising efforts (12.9%, 38/295), assist in early detection (11.5%, 34/295), promote a charitable organization (10.2%, 30/295), support disease management (3.7%, 11/295), cancer prevention (2.0%, 6/295), or social support (1.0%, 3/295). The majority of the apps did not describe their organizational affiliation (64.1%, 189/295). Apps affiliated with non-profit organizations were more likely to be free of cost (χ² ₁=16.3, P<.001) and have a fundraising or awareness purpose (χ² ₂=13.3, P=.001). The review of the health literature yielded 594 articles, none of which reported an evaluation of a cancer-focused smartphone application.

Conclusions

There are hundreds of cancer-focused apps with the potential to enhance efforts to promote behavior change, to monitor a host of symptoms and physiological indicators of disease, and to provide real-time supportive interventions, conveniently and at low cost. However, there is a lack of evidence on their utility, effectiveness, and safety. Future efforts should focus on improving and consolidating the evidence base into a whitelist for public consumption.     

药动学研究常用软件介绍

药动学是一门研究药物体内动态变化规律及其影响因素的学科。药动学模型研究从经典的房室模型,统计矩理论的应用,到复杂的群体药动学、生理药动学以及药动-药效学建模,都需要可靠的软件工具来完成复杂的数学计算过程。一些商业公司开发的药动学模型专业软件,已在药物研发和科学研究中广为应用;另一方面,开源工具正得到大力推广。本文总结目前用于药动学模型研究的主流软件工具,对其功能应用做简要介绍,以期为国内相关研究者提供有价值的信息。     

CTA观察女性髂内动脉分型和子宫动脉起源及角度的意义

目的探讨X线电子计算机断层扫描血管成像(CTA)检查对研究女性髂内动脉分型和子宫动脉起源及角度的意义。方法选取2011年7月至2012年12月因各种盆腔病变在我院行盆腔CTA检查的108例患者,通过Start Vitrea2工作站对图像进行后处理,参照Adachi等的分型标准对髂内动脉进行分型及对比分析,并对子宫动脉的起源及角度进行研究。结果髂内动脉分型情况:Ⅰ型占61.2%(132/216)、Ⅱ型占9.7%(21/216)、Ⅲ型24.1%(52/216)、Ⅳ型4.7%(10/216)、V型占0.5%(1/216)。此外,子宫动脉起源以臀下阴部干最常见(40.1%),其次是髂内动脉主干和阴部内动脉,所占比例分别为19.3%和18.4%;子宫动脉的夹角小于30°约占62.3%,其开口显像的最佳角度多常见于15°~30°。结论术前行CTA检查可以清楚地了解髂内动脉分型和子宫动脉起源及角度,对介入治疗及盆腔手术有重要的指导意义。     

Telemedicine and type 1 diabetes: Is technology per se sufficient to improve glycaemic control?

AimIn the TELEDIAB-1 study, the Diabeo system (a smartphone coupled to a website) improved HbA_1c by 0.9% vs controls in patients with chronic, poorly controlled type 1 diabetes. The system provided two main functions: automated advice on the insulin doses required; and remote monitoring by teleconsultation. The question is: how much did each function contribute to the improvement in HbA_1c?MethodsEach patient received a smartphone with an insulin dose advisor (IDA) and with (G3 group) or without (G2 group) the telemonitoring/teleconsultation function. Patients were classified as “high users” if the proportion of “informed” meals using the IDA exceeded 67% (median) and as “low users” if not. Also analyzed was the respective impact of the IDA function and teleconsultations on the final HbA_1c levels.ResultsAmong the high users, the proportion of informed meals remained stable from baseline to the end of the study 6 months later (from 78.1 ± 21.5% to 73.8 ± 25.1%; P = 0.107), but decreased in the low users (from 36.6 ± 29.4% to 26.7 ± 28.4%; P = 0.005). As expected, HbA_1c improved in high users from 8.7% [range: 8.3–9.2%] to 8.2% [range: 7.8–8.7%] in patients with (n = 26) vs without (n = 30) the benefit of telemonitoring/teleconsultation (−0.49 ± 0.60% vs −0.52 ± 0.73%, respectively; P = 0.879). However, although HbA_1c also improved in low users from 9.0% [8.5–10.1] to 8.5% [7.9–9.6], those receiving support via teleconsultation tended to show greater improvement than the others (−0.93 ± 0.97 vs −0.46 ± 1.05, respectively; P = 0.084).ConclusionThe Diabeo system improved glycaemic control in both high and low users who avidly used the IDA function, while the greatest improvement was seen in the low users who had the motivational support of teleconsultations.