Choreoathetosis related to lithium intoxication

A 76-year old woman was admitted because of severe gait ataxia and dysarthric speech that had worsened over the last 24 h. The patient was initially suspected of having repeated transitory ischemic attacks (TIAs) as her daughter reported a similar episode that had happened 3 weeks prior to admission. The onset of spontaneous twisting, choreoathetotic movements of both hands and arms and worsening of symptoms one hour after admission together with a history of lithium therapy lead to the correct diagnosis and appropriate treatment.     

小檗碱对大鼠再灌心律失常及钙调节的作用

小檗碱（Ｂｅｒ，１０ｍｇ·ｋｇ－１）使缺血／再灌后ＶＴ发生率明显降低，持续时间明显缩短，无１例发生ＶＦ及死亡，与对照组比较差异有显著性。离体实验表明：小檗碱（３０μｍｏｌ·Ｌ－１），能抑制高钙条件下Ｃａ２＋内流，而增加低钙条件下的Ｃａ２＋内流。结果表明：小檗碱具有预防再灌心律失常作用；不同Ｃａ２＋浓度能够影响心肌４５Ｃａ内流；小檗碱对心肌Ｃａ２＋内流有双向调节作用，尤其在高Ｃａ２＋条件下，降低４５Ｃａ内流可能是其抗心律失常作用机制之一。     

脑卒中患者下丘脑─垂体─肾上腺皮质轴功能改变及临床意义

观察了１７２例脑卒中患者血清促肾上腺皮质激素（ＡＣＴＨ）、皮质醇的变化，发现ＡＣＴＨ、皮质醇水平明显高于正常对照组，脑出血组高于脑梗塞组；病情轻重与ＡＣＴＨ、皮质醇的变化明显相关。治疗前后ＡＣＴＨ、皮质醇水平明显不同，治疗后明显降低（Ｐ＜０．０１）。说明治疗后可改善下丘脑－垂体－肾上腺皮质轴（Ｈ／Ｐ／Ａ）功能紊乱。     

藻酸双酯钠治疗缺血性脑血管病102例效果分析

应用藻酸双酯钠对102例缺血性脑血管病患者进行治疗。观察用药前后症状与体征及血流动力学的变化。结果;显效率为70.32％,有效率为29.68％,总有效率达100％。     

大鼠局灶性脑缺血再灌注模型的建立及其组织形态改变

目的：建立大鼠脑缺血2h再灌注不同时程实验动物模型，探讨其病理形态学HE染色特点。方法：线栓法行大鼠大脑中动脉闭塞(MCAo)造成局灶性脑缺血2h再灌注模型，假手术组不插入线栓。HE染色观察病理组织形态学特点。结果：所有局灶性脑缺血再灌注模型在麻醉苏醒后均表现为局灶性神经功能缺陷。再灌注后3h，神经功能缺陷部分恢复。这些表现与临床局灶性脑缺血再灌注溶栓治疗的病人相似。HE染色可见胞浆均质红染、细胞核固缩以及细胞膜和细胞结构破坏的嗜伊红的死亡神经元。结论：Wistar大鼠局灶性脑缺血再灌注模型的神经功能缺损与人类缺血性脑血管病相近，是研究脑缺血再灌注损伤的病理形态学机制的良好模型。     

医疗器械不良事件监测-现状与展望

介绍医疗器械不良事件的基本概念,论述美国、欧盟、日本和有关国际组织关于医疗器械不良事件监测的管理规定,并回顾和展望我国在该领域的相关工作.     

急性缺血性卒中抗凝治疗研究进展

急性缺血十牛卒中的抗凝治疗存在着很大的争议。本文综述了常用抗凝药物如肝素、低分子肝素的作川机制，并从循证医学角度对近年来发表的一些关于急性缺血性卒中抗凝治疗的大型临床试验进行了总结。     

河北省部分城镇白领人群脑血管病危险因素调查

目的:调查河北省城镇白领人群的脑血管病危险因素。方法:选取石家庄市部分白领人群,由专业医师进行询问病史,查体,检测血脂、血糖,巨细胞病毒晚期抗原PP65与抗体IgG、IgM检测,心电图,胸透,B型超声检查肝、胆及颈动脉、椎动脉。结果:高血压患病率43．38％,城镇白领阶层高血压患病率显著高于普通人群(35．7％);高血脂男性发生率45．79％,女性为17．24％:男性公务员高血脂发生率与其他职业人群比较有统计学意义;糖尿病患病率为8．82％,职业间和性别间无统计学意义;颈、椎动脉超声检查,发现39．71％的人颈动脉或椎动脉有动脉粥样硬化病变,男性发生率40．19％,女性发生率37．93％,男性稍高于女性,职业间、性别间无统计学意义;长期大量饮酒率为82．3％,男性吸烟率56．07％;巨细胞病毒(HCMV)激活感染率3．68％。结论:存在心脑血管疾病高危因素的共有129人,占94．85％,其中86．76％的人存在两个或两个以上危险因素。采取早预防、早治疗的方针,关注城镇白领人群常见的脑血管病的危险因素对我国的可持续发展有重要战略意义。     

Cerebrovascular deaths before and after the appearance of oral contraceptives

The mortality of cerebrovascular diseases in Denmark was analysed for men and women 15-44 years of age, in a 14-year period before and after the appearance of oral contraceptives (OC) in 1966. 1,670 deaths were registered over 28 years, during which the female incidence of cerebrovascular deaths increased by 19% (P less than 0.025), while the male mortality was unchanged. Women showed a percentage increase in deaths from cerebral thromboembolic attacks (CTA) of 33%, men a fall of 14%. The increase of female CTA deaths was most pronounced in the young fertile group, the age group with a high OC use. A relative risk of CTA of 3.3-4.5 for OC users compared with non-users could explain the CTA trend difference between women and men. No other single risk factor responsible for the observed trends could be identified. Both women and men had a significant increase in the mortality of subarachnoidal hemorrhages, and a significant fall in the mortality of intracerebral hemorrhages.