温针背俞穴治疗黄褐斑疗效观察

目的观察温针背俞穴治疗黄褐斑的临床疗效。方法将100例黄褐斑患者随机分为治疗组52例和对照组48例。治疗组采用温针背俞穴治疗,对照组采用常规针刺治疗。两组均治疗3个疗程并随访1个月对比疗效。结果治疗组总有效率为96.1%,对照组为85.4%,两组比较差异具有统计学意义(P<0.05)。结论温针背俞穴是一种治疗黄褐斑的有效方法。     

结肠黑变病的形态学与组化研究

目的研究结肠黑变病的临床病理特点和病理性色素的性质。方法全部病例作了临床资料分析及组织学观察;15例作了脂褐素、黑色素、含铁血黄素和胆色素染色;5例作了En Vosion法免疫组化染色及电镜检查。结果结肠黑变病黏膜固有层都有棕褐色色素沉着,该色素的脂褐素、黑色素、含铁血黄素和胆色素染色均为阴性;HMB45、S-100免疫组化染色该色素颗粒亦为阴性;电镜见该色素为脂褐素样物质。结论结肠黑变病在很大程度上与便秘服泻药有关,色素可能系巨噬细胞吞噬蒽醌类泻剂后形成的脂褐素样物质,它能否导致结直肠肿瘤有待进一步研究。     

Chediak-Higashi syndrome

A case of Chediak-Higashi syndrome is reported in a four-year-old boy who presented with recurrent chest infection, partial albinism, hyperpigmentation of the extremities and presence of giant granules in leucocytes and melanocytes in the skin. Parental consanguinity was present. Though uncommon, hyperpigmentation of sun exposed areas may be the initial symptom in Chediak-Higashi syndrome.     

Laryngeal melanosis: a case report and review of the literature

We present a case with laryngeal melanosis and discuss the clinical significance of this condition. A 58-year-old male patient was referred to the otolaryngology department with a 2-month history of hoarseness. He had a history of smoking 20 cigarettes a day for 40 years. Videolaryngosgopic examination showed chronic laryngitis findings with multifocal pigmented pachydermic areas. Multiple biopsies were performed by laryngomicrosurgery. Pathological examination revealed laryngeal melanosis. As the number is not much enough, the association of laryngeal melanosis and carcinogenesis seems to be controversial. In the point of management, we have to be aware of the risks of laryngeal melanosis, such as developing neoplasm, and monitor the patients closely by periodical examinations and biopsies and advise the patients to stop smoking.     

结肠黑变病与中医体质相关性研究

目的探讨结肠黑变病(MC)与中医体质相关性,为MC防治提供依据。方法对78例MC患者进行中医体质辨识,分析体质类型与性别、年龄相关性。结果 MC患者最常见的体质类型为气虚质、阴虚质、湿热质、气郁质、痰湿质;不同性别MC患者中医体质类型分布比较差异无统计学意义(P0.05);老年MC患者中,气虚质、阴虚质所占比例大于其他体质类型(P0.05)。结论 MC中医体质类型主要由气虚质、阴虚质、湿热质、气郁质、痰湿质构成,并与年龄因素密切相关,老年MC患者中医体质以气虚质、阴虚质为主。     

Melanosis of the prostate: an immunohistochemical study

We report here a case of prostatic melanosis examined immunohistochemically. The patient was a 70-year-old man with prostatic hyperplasia. Six foci with brown pigmentation were found, not only in stromal cells but also in glandular epithelial cells among many pieces of prostatic tissue. Immunohistochemically, only pigment-laden stromal cells were obviously positive with antibodies to S-100 protein and melanoma (HMB45), but not for CD57, while epithelial cells were only positive for CD57 after depigmentation with bleaching. This is the first report demonstrating immunopositivity of stromal cells for antimelanoma antibody (HMB45), which can label reactive or dysplastic but not normal melanocytes. These results clearly demonstrated that pigment-laden stromal cells are neuroectodermal in origin, and probably reactive or dysplastic but not normal melanocytes.     

结肠黑变病对结直肠息肉的影响

目的研究结肠黑变病对结肠息肉发生率、病理类型等的影响。 方法回顾性分析自2012年8月至2015年12月在我院经全结肠镜诊断的结肠黑变病98例,组成黑变病组;随机选取结肠镜诊断无结肠黑变病252例,组成非黑变病组。比较两组一般情况、结肠息肉发病率、息肉病理类型等。 结果结肠黑变病II度、III度累及全结肠的比例分别为71.0%、78.6%,高于黑变病I度的50.9%（P=0.01）。结肠黑变病组结肠息肉发现率达40.8%,远高于非结肠黑变病的23.0%（P=0.001）,而且黑变病组在横结肠、降结肠、盲肠及全结肠≥3个部位发现结肠息肉的比例均高于非黑变病组,P均<0.05,但两组息肉中腺瘤的比例分别为80%、67.9%（P=0.117）,差异无统计学意义。黑变病I、II、III度在息肉检出率、息肉病理类型的比较上,均P>0.05,差异无统计学意义。左半结肠为主型、右半结肠为主型、全结肠型黑变病在息肉检出率、息肉病理类型的比较上,也均P>0.05,差异无统计学意义。 结论结肠黑变病患者结肠息肉发生率高,需加强对结肠黑变病患者肠镜筛查,预防结直肠癌发生。结肠黑变病的病变程度、部位对结肠息肉的检出率、病理类型无影响。     

Riehl黑变病激光共聚焦扫描显微镜和皮肤镜成像特征分析

目的 联合运用皮肤镜、激光共聚焦扫描显微镜（CLSM）观察Riehl黑变病的成像特点,并结合组织病理探讨其间的联系。 方法 皮肤科门诊收集确诊为Riehl黑变病患者10例,所有患者用皮肤镜与CLSM共同检测后做组织病理学检查。 结果 所有Riehl黑变病的患者经皮肤镜与CLSM检测后的主要特征为：网络状结构,基底层液化变性及色素失禁。 结论 皮肤镜及CLSM可以作为Riehl黑变病的无创性辅助诊断技术。     

先天性弥漫性黑变病1例

患儿女,3岁。初生时和出生后全身皮肤进行性弥漫性色素沉着。腋下、颈部、腹股沟有点状白斑。头发发黄,血、尿常规、规、肝肾功能、肾上腺皮质功能检查未见异常。组织病理检查示棘层中下部和基底黑色素增加,真皮浅层有大量嗜黑素细胞。     

A Clinical and Biochemical Evaluation of a Temperature-Controlled Continuous Non-Invasive Radiofrequency Device for the Treatment of Melasma

BackgroundMelasma shows characteristic histological features of photoaged skin.ObjectiveWe evaluated the effect of dermal rejuvenation using a temperature-controlled continuous non-invasive radiofrequency (RF) device on melasma.MethodsContinuous skin heating at the temperature of 43°C for 20 minutes was performed in ten subjects with melasma who underwent 3 tri-weekly RF sessions. Pigmentation was evaluated with Mexameter® and investigator’s global assessment (IGA). Immunohistochemical staining and image analysis was performed to evaluate biopsies from melasma skin before and after the treatment.ResultsThe lesional melanin index was decreased by 13.7% at week 9. IGA score was improved from 3.50 at baseline to 2.95 at week 9. No significant adverse event was reported. Histologic analysis revealed reduced melanin and increased collagen density and thickness. The expression of procollagen-1 and type IV collagen was increased after the treatment. The number of p16^INK4A-positive senescent fibroblasts was reduced after the treatment, while the expression of heat shock protein 70 and 90 was increased. Stromal derived factor-1, a senescence-associated anti-melanogenic factor secreted from the fibroblasts, was up-regulated after the treatment, while the level of c-kit was not changed.ConclusionThermal skin stimulation by the temperature-controlled continuous RF device improved melasma through dermal rejuvenation.