全文获取类型
收费全文 | 15023篇 |
免费 | 580篇 |
国内免费 | 149篇 |
专业分类
耳鼻咽喉 | 518篇 |
儿科学 | 839篇 |
妇产科学 | 191篇 |
基础医学 | 782篇 |
口腔科学 | 221篇 |
临床医学 | 1424篇 |
内科学 | 2280篇 |
皮肤病学 | 735篇 |
神经病学 | 1104篇 |
特种医学 | 1191篇 |
外国民族医学 | 1篇 |
外科学 | 2795篇 |
综合类 | 856篇 |
预防医学 | 618篇 |
眼科学 | 667篇 |
药学 | 809篇 |
4篇 | |
中国医学 | 222篇 |
肿瘤学 | 495篇 |
出版年
2024年 | 14篇 |
2023年 | 130篇 |
2022年 | 316篇 |
2021年 | 440篇 |
2020年 | 200篇 |
2019年 | 380篇 |
2018年 | 495篇 |
2017年 | 345篇 |
2016年 | 229篇 |
2015年 | 212篇 |
2014年 | 407篇 |
2013年 | 526篇 |
2012年 | 286篇 |
2011年 | 317篇 |
2010年 | 297篇 |
2009年 | 335篇 |
2008年 | 409篇 |
2007年 | 396篇 |
2006年 | 248篇 |
2005年 | 210篇 |
2004年 | 241篇 |
2003年 | 390篇 |
2002年 | 1226篇 |
2001年 | 1591篇 |
2000年 | 1762篇 |
1999年 | 1101篇 |
1998年 | 1063篇 |
1997年 | 938篇 |
1996年 | 496篇 |
1995年 | 212篇 |
1994年 | 82篇 |
1993年 | 43篇 |
1992年 | 40篇 |
1991年 | 36篇 |
1990年 | 26篇 |
1989年 | 33篇 |
1988年 | 28篇 |
1987年 | 16篇 |
1986年 | 19篇 |
1985年 | 31篇 |
1984年 | 28篇 |
1983年 | 36篇 |
1982年 | 21篇 |
1981年 | 25篇 |
1980年 | 16篇 |
1979年 | 12篇 |
1978年 | 7篇 |
1977年 | 15篇 |
1976年 | 8篇 |
1975年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
11.
More than just crushing: a prospective pre‐post intervention study to reduce drug preparation errors in patients with feeding tubes 下载免费PDF全文
12.
《Vaccine》2016,34(48):5912-5915
Immunochromatography (ICG) is highly used in clinical settings for rotavirus (RV) diagnosis. The specificity of the tests differs by brand type and is not 100%, therefore its use when the prevalence of the disease is low (i.e. in vaccinated children) may result in a proportion of false positive diagnoses.In some areas, vaccine effectiveness studies or surveillance is done using ICG. Our objective was to estimate the validity of ICG test in vaccinated children, and estimate the number of false positive results in the Valencian Region of Spain, where all RV infections are diagnosed using ICG and are not confirmed by PCR.Population based registries were used to identify all results from the RV antigen tests performed between January 2008 and June 2012 in children under 37 months. Hospitalization and vaccination status of the patients were obtained by linking different databases through a unique identification number. The Positive Predictive Value of the ICG test depending on the vaccination status of the child, hospitalization and the rotavirus season was estimated by a Bayesian model of latent classes.Of the 48,833 tests with valid results, 9429 were done in vaccinated children, and of those 3963 (42%) during the rotavirus season. The prevalence of positive results in vaccinated varied from 2.9 to 21.4% of the tests depending on the hospitalization and seasonality. The estimated PPV also varied from 27.1 to 84.6% when stratified by these two parameters. Globally it is calculated that approximately 267 out of the 520 (51.3%) positives in vaccinated children were false positive tests.The large percentage of false positives, due to an excessive number of tests in vaccinated and out of the RV season, if interpreted as vaccine failures, can cause a loss of confidence in the vaccine and lower the estimates of vaccine effectiveness. 相似文献
13.
BackgroundWomen suffering from kidney disease are more prone to fertility problems, due to uremia. Fortunately, their fertility rate increases dramatically after renal transplantation. This study analyzes the predictors/risk factors of successful pregnancy with live birth outcome while presenting an overview of the 7-year experience of a single center.MethodsThis retrospective cohort study includes 239 women of reproductive age (18–40 years) who underwent renal transplantation in a tertiary Turkish clinic between October 1, 2011, and August 24, 2017. The subjects were invited to take part in a survey questioning their obstetric characteristics and they were assessed in 2 groups: fertile and infertile. Multivariable linear regression analysis was conducted to determine the predictors of a successful pregnancy.ResultsThirty-five 35 patients wished to become pregnant: 12 got pregnant spontaneously, while 21 failed to become pregnant (spontaneously). The mean age of the patients at the survey was 34 ± 7. Regular menstrual cycles after renal transplantation, tacrolimus-mycophenolate mofetil maintenance protocol, and age at transplantation were found to be predictors of spontaneous pregnancy. The duration of peritoneal dialysis was significantly longer in the infertile group (48 vs 12 months).ConclusionEnd-stage renal disease's negative impacts, including menstrual abnormality and fertility problems, can be overcome by successful kidney transplantation with appropriate immunosuppression. Minimizing the duration of peritoneal dialysis, particularly in patients who desire future fertility, may be accepted as a logical management strategy. 相似文献
14.
《Radiography》2020,26(4):e195-e200
IntroductionAdverse events in radiology are quite rare, but they do occur. Radiation safety regulations and the law obligate organizations to report certain adverse events, harm and near misses, especially events related to patients' health and safety. The aim of this study was to describe and analyse incidents related to radiation safety issues reported in Finland.MethodsThe data were collected from incident reports documented by radiology personnel concerning notifications of abnormal events in medical imaging made to the Radiation and Nuclear Safety Authority between 2010 and 2017. During these eight years, 312 reports were submitted. Only events reported from radiology departments were included; nuclear medicine, radiotherapy and animal radiology cases were excluded. The final number of reports was 293 (94%).ResultsThe majority of the 293 approved reports were related to computed tomography (CT, 68.3%) and to X-ray examinations (27.6%). Altogether 82.9% of those irradiated were adults, most of whom were exposed to unnecessary radiation through CT (86.5%), 5.5% were children, and 4.4% pregnant women. The most common effective dose of unnecessary radiation was 1 mSv or less (89.7% of all examinations). The highest effective doses were reported in CT (from under 1 mSv–20 mSv and above). The reasons for the adverse events were incorrect identification (32%), incorrect procedure, site or side (30%); and human errors or errors of knowledge (20%).ConclusionAdverse events occurred especially in CT examinations. It is important to collect and analyse incident data, assess the harmful events, learn from them and aim to reduce adverse events.Implications for practiceThis study emphasizes the need for radiological personnel to obtain evidence-based information on adverse events and focus on training to improve patient safety. 相似文献
15.
D. Sforza G. Iaria L. Petagna A. Parente A. Anselmo F. Sergi S. Marzio F. Corrado S. Telli T.M. Manzia G. Tisone 《Transplantation proceedings》2019,51(1):140-142
Background
One daily dose of tacrolimus (QDT) improves adherence in kidney transplant (KT) recipients. A switch from twice-daily tacrolimus (BDT) to QDT showed similar efficacy and safety.Methods
The aim of our study was to demonstrate the long-term efficacy and safety of switching from BDT to QDT in KT recipients. Preliminary results have already been published. Forty-one patients (34 men and 7 women), mean age at KT of 43.9 ± 12.7 years, underwent a 1:1 dose switch from BDT to QDT; the mean time from KT to switch was 36.6 ± 16.1 months. In our study population, 4 patients received a living donor KT and 2 received a second allograft.Results
The mean follow-up was 86.8 ± 13 months from the switch and 126.2 ± 22.3 months from KT. Graft and patient survival rates were 90.2% and 95.1%, respectively. All patients maintained stable renal function during follow-up. During the first 3 months after the switch we observed a significant decrease in tacrolimus blood level (P = .0001). No significant differences were observed regarding tacrolimus dose before and after QDT introduction (P = not significant [NS]). Fourteen patients who stopped steroids under BDT treatment and 16 patients who stopped steroids after the switch are currently steroid-free.Conclusion
Our study showed safety and efficacy in switching from BDT to QDT. After early (<1 year) dose adjustment, tacrolimus blood levels remained stable throughout follow-up. Moreover, QDT represented a valid alternative for patients showing steroid side effects. 相似文献16.
Petra Schwingenschuh Karoline Wenzel Petra Katschnig Ronald Saurugg Erwin Ott 《Movement disorders》2007,22(5):742-745
We describe a case of a palatal tic resembling palatal tremor (PT) in a young female patient with a previously unrecognized mild Tourette syndrome. At the time of her visit, the patient complained about ear clicks that were audible to others. We discuss the differential diagnoses of hyperkinetic palatal movements emphasizing the ongoing discussion about essential PT representing a more heterogeneous disorder than previously thought. 相似文献
17.
强化护理安全减少护理差错 总被引:2,自引:1,他引:1
目的 通过对护理差错原因分析,制定护理安全管理措施。方法 对近7年的护理差错及发生率进行统计学分析,P〈0.001,有显著差异。结果 差错发生率逐年下降,护理质量平均达标率达99%。结论 强化护理安全管理,制定切实可行的管理措施,才能减少护理差错的发生, 相似文献
18.
K. Reynen U. Röber W.G. Daniel R. Henßge S. Schüler 《Clinical research in cardiology》1998,87(5):331-335
Zusammenfassung Zahlen zur H?ufigkeit von Herztumoren im operativen Krankengut liegen bisher für die Bundesrepublik Deutschland nicht vor.
Um einen entsprechenden überblick für das Jahr 1996 zu erhalten, wurde allen 77 herzchirurgischen Zentren der Bundesrepublik
Deutschland ein standardisierter Fragebogen zugesandt.
Daten von 65 der 77 Herzzentren (=84%) waren schlie?lich verfügbar: 187 Patienten waren wegen Myxomen, lediglich 44 wegen
nichtmyxomat?sen Tumoren, davon 28 wegen malignen prim?ren oder sekund?ren Herztumoren, operiert worden. Im Jahr 1996 waren
somit 0,32% (231/72 763) der Eingriffe mit Herz-Lungen-Maschine (erfa?t 72 763 von insgesamt 87 372) wegen eines Herztumors
vorgenommen worden. Ausgehend von diesen operativen Daten liegt die Inzidenz ausschlie?lich der prim?ren Tumoren des Herzens
zumindest bei 3 Tumoren pro 1 Million Einwohner pro Jahr (253 Tumoren/81,814 Millionen Einwohner). Wenn auch kleine Tumoren
asymptomatisch und unentdeckt bleiben k?nnen, wird heute doch die Mehrzahl prim?rer kardialer Tumoren durch Echokardiographie,
Computer- und Kernspintomographie bereits zu Lebzeiten des Patienten diagnostiziert, und diese Patienten werden in aller Regel
einer Operation zugeführt.
Somit werden gut 0,3% aller Eingriffe mit Herz-Lungen-Maschine in Deutschland wegen Herztumoren durchgeführt, wobei es sich
weit überwiegend um Myxome handelt.
Eingegangen: 23. September 1997, Akzeptiert: 11. Februar 1998 相似文献
19.
Wolfgang Söllner Gerlinde Mairinger Martina Zingg-Schir Peter Fritsch 《Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete》1996,47(3):200-205
Zusammenfassung
Bei 205 Melanompatienten im Stadium I und II wurden das Ausma? der psychosozialen Belastung und der sozialen Unterstützung
sowie die Einstellung der Patienten zu unterstützenden Gespr?chsangeboten erhoben. 59% der Patienten fanden zus?tzliche unterstützende
Gespr?che mit dem behandelnden Dermatologen, 20% mit einem Psychotherapeuten sinnvoll. Patienten, die starke Angst vor einem
Fortschreiten des Tumors ?u?erten und die sich über die Erkrankung nicht ausreichend aufgekl?rt fühlten, wünschten Gespr?che
mit dem behandelnden Arzt. Patienten, die sich psychosozial st?rker belastet fühlten und sozial weniger Unterstützung durch
ihr soziales Umfeld angaben, befürworteten Unterstützung durch einen Psychotherapeuten. Auch eine ungünstige Prognose scheint
das Interesse an psychotherapeutischer Unterstützung zu verst?rken.
Eingegangen am 13. Januar 1995 Angenommen am 23. August 1995 相似文献
20.
重组结核分支杆菌16000蛋白抗原(rPA16)的免疫原性研究 总被引:3,自引:0,他引:3
目的:研究结核分枝杆菌重组16000蛋白(rPA16)诱发家兔产生抗体的能力并评价其血清学诊断的价值。方法:家兔按注射的抗原及佐剂的不同分组,皮下多点注射分别进行免疫,6次免疫后采血,双向琼脂扩散试验和酶联免疫吸附试验(ELISA)跟踪兔血清抗体效价的时间效应并检测兔血清与所试各类分支杆菌PPD有无交叉反应;同时检测rPA16与各分支杆菌PPD的免疫羊血清的反应,并用rPA16抗原检测人血标本,分析该抗原的临床检测的敏感性和特异性。结果:兔血清抗体效价结果显示:5个月后,加佐剂的抗原组的兔免疫血清仍能检测到抗体,不加佐剂组2个月后血清抗体检测即为阴性,ELISA检测兔免疫血清比双向琼脂扩散方法要更敏感,rPA16抗原加佐剂引起的兔血清抗体滴度最高可达1:6400,不加佐剂组的血清抗体滴度仅为1:400,ELISA法分析抗rPA16的兔血清的特异性表明其特异笥较好,仅与牛、人型结核分支杆菌的PPD呈阳性反应,与其他所试分支杆菌PPD反应均为阴性,同时又分析了rPA16抗原的特异性,与人型PPD相比,该抗原只与所试各类分支杆菌,BCG、牛分支杆菌免疫的血清呈阳性反应,而人型PPD则基本上与结核分支杆菌免疫的血清均呈阳性反应,ELISA检测血清标本结果:肺结核病组中rPA16和PPD检测敏感性分别为64.8%和75.2%;健康组,卡介苗接种阳转健康组,rPA16和PPD检测特异性分别为96.2%,88.5%和94.3%,66.7%。结论:rPA16具有较强的免疫原性和一定的特异性,可能成为结核病血清学诊断试剂之一。 相似文献