利用聚茜素红薄膜修饰电极测定阿昔洛韦

OBJECTIVE To setted up a new electroanalysis method for determining Aciclovir using the electrocatalysis action of PARSE on Aciclovir.METHODS In 0.05mol/L PBS(pH=6.86)+0.3mol/L NaCl solution,the CV figures were obtained for cyclic scanning from 0V to 1.2V     

阿昔洛韦与盐酸左旋氧氟沙星注射液配伍稳定性的试验研究

目的在室温下考察阿昔洛韦与盐酸左旋氧氟沙星注射液配伍稳定性。方法采用分光光度法测定配伍液中阿昔洛韦及盐酸左旋氧氟沙星的含量变化,并在200~400nm进行紫外扫描,同时观察外观及pH值变化。结果配伍液尽管在8h内pH值、吸收峰峰形及峰位无明显变化,但颜色、含量及吸收峰峰值有变化。结论临床应用时,二者需分开输注,不宜混合配伍应用。     

一阶导数光谱法测定阿昔洛韦滴眼液的含量

目的:建立阿昔洛韦滴眼液含量测定方法。方法:用一阶导数光谱法不经分离直接测定阿昔洛韦滴眼液的含量,选择阿昔洛韦测定波长为235nm,在5～25 μg·ml~(-1)范围内线性关系良好。结果:阿昔洛韦平均回收率99.7％(RSD=0.55％,n=5),r=0.999 8,结论:本方法简便、准确。可用于药品生产中的质量控制。     

阿昔洛韦和双氯芬酸钠、贝复舒联合治疗单纯疱疹病毒性角膜炎

目的观察阿昔洛韦联合双氯芬酸钠、重组牛碱性成纤维细胞生长因子(贝复舒)滴眼液治疗单纯疱疹病毒性角膜炎的效果。方法对150例(172眼)患者随机分为治疗组75例(90眼)和对照组75例(82眼)。治疗组患者滴0.1%阿昔洛韦滴眼液、双氯芬酸钠滴眼液和贝复舒滴眼液;对照组滴用阿昔洛韦滴眼液。结果治疗组治愈(91.00%),对照组治愈率(75.60%),经统计学处理,差异有统计学意义(P<0.01);治疗组有效率(96.67%),对照组有效率(89.00%),差异有统计学意义(P<0.05)。结论阿昔洛韦联合贝复舒、双氯芬酸钠治疗单纯疱疹病毒性角膜炎疗效较肯定,治愈率高,是较合理安全的用药方法。     

Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir

In the present study multiple W/O/W nanoemulsions were optimised for the dermal application of the antiviral drug aciclovir. The phase inversion temperature method was employed to prepare the formulations without the input of high pressure. During formulation design the ethoxylated surfactants were varied and if possible partly replaced by natural sugar surfactants. Multiple nanoemulsions with mean droplet sizes around 100 nm and polydispersity indices below 0.1 were prepared. At room temperature, they exhibited excellent physicochemical stability over an observation period of 6 months. Furthermore, cryo electron microscopy gave an insight into the microstructure of the multiple nanoemulsions. Moreover, the formulations' interaction with skin was analysed by ATR-FTIR. In Franz-type diffusion cell and tape stripping experiments aciclovir showed satisfying skin permeation from the novel nanoemulsions.     

阿昔洛韦多囊脂质体的制备工艺优选

目的:制备包封率高、稳定性好的阿昔洛韦(ACV)多囊脂质体。方法:采用复乳法制备ACV多囊脂质体,以包封率为指标,以润滑剂三油酸甘油酯量(A)、药脂比(B)、缓冲液的pH值(C)及辅助乳化剂吐温-80的用量(D)为因素,设计正交试验优选工艺;采用紫外分光光度法测定其中主药含量并计算包封率;考察优选工艺所制制剂不同条件下7d内包封率的变化并计算渗漏率。结果:最佳工艺为A0.50g、B5∶150、C6.5、D0.40g,所制多囊脂质体包封率为85.82%,常温条件下贮存7d渗漏率为5.84%。结论:采用优选工艺制备的ACV多囊脂质体方法简单,包封率较高,常温下较稳定。     

流行性角结膜炎治疗的患者舒适度及病程调查

目的 总结出流行性角结膜炎舒适、缩短病程的治疗方法,供大家借鉴与参考（探讨流行性角结膜炎不同治疗方法疗效,为临床治疗方法的选择提供科学依据）。方法120例流行性角结膜炎患者,随机分为3组,分别接受三种不同的治疗方法,彼此对照,分析其临床意义。结果 接受干扰素配成眼药水治疗组,患者普遍感到舒适,但不缩短病程;接受阿昔洛韦眼药水、利巴韦林眼药水及微量地塞米松注射液混合制剂点眼组,患者感到病情明显好转,大多数用药3d痊愈,缩短病程;而接受阿昔洛韦眼药水治疗组,患者仍然感到疾病痛苦,病程并不缩短。结论流行性角结膜炎患者接受干扰素配成眼药水治疗会感到疾病痛苦明显减轻,明显改善症状,但不缩短病程;阿昔洛韦眼药水、利巴韦林眼药水及微量地塞米松配成混合制剂点眼,患者感到明显好转,缩短病程,受到患者欢迎,两种方法均优于阿昔洛韦眼药水点眼治疗,是治疗流行性角结膜炎的良好方法。     

Presentación atípica de infección por virus de herpes simple tipo ii (VHS II) refractaria a tratamiento con aciclovir en 2 pacientes hematológicos

Herpesvirus infections are not uncommon in hematologic patients. Our first patient, diagnosed with chronic lymphatic leukemia, presented extensive genital herpes infection refractory to treatment with aciclovir and with a partial response to foscarnet, which had to be withdrawn due to systemic adverse effects. The second patient, diagnosed with follicular Hodgkin lymphoma, presented hypertrophic herpes infection refractory to treatment with aciclovir but that responded to intralesional cidofovir and topical imiquimod. As in other immunocompromised patients, herpesvirus infection in hematologic patients can present atypical manifestations, as well as resistance to treatments that are activated by the viral thymidine kinase. A high level of clinical suspicion is therefore needed to make an early diagnosis, together with extensive knowledge of the different treatments available.     

泛昔洛韦与阿昔洛韦治疗带状疱疹临床对比观察

目的 评价泛昔洛韦治疗带状疱疹的疗效和安全性。方法 将60例带状疱疹患者随机分为治疗组泛昔洛韦250mg一日三次和对照组阿昔洛韦200mg一日五次。治疗后第1,3,5,7,8天观察记录。结果 治疗组与对照组在水疱干涸时间和疱疹缓解开始时间比较有显著性差异（P＜0．01）,在水疱停止出现时间和完全结痂时间比较无显著性差异（P＞0．05）。两组病例不良反应相似且轻微。结论 泛昔洛韦是治疗带状疱疹的安全有效药物。