性病门诊三种人群解脲支原体和人型支原体感染的研究

本研究采用培养法对２４１例性病患者，３７例性乱者，８９例性病伴侣及１１８例健康人群进行解脲支原体与人型支原体的检测。结果显示：性病，性乱者和性病伴侣感染Ｕｕ与Ｍｈ总阳性率分别为４２．３２％，３５．１４％和３４．２０％，与健康人群比较，差异有非常显著性，三者之间比较，差异无显著性。     

马洛替脂治疗大鼠脂肪肝实验性研究

我院脂肪肝研究小组开展了多种药物的动物试验研究,其中观察了马洛替脂治疗大鼠脂肪肝实验结果,发现疗效不甚明显,但有一定改善大鼠肝纤维化作用。     

PCR对男性衣原体和支原体尿道炎的诊断价值

ＰＣＲ对男性衣原体和支原体尿道炎的诊断价值谢锦来黄明志李励献罗立君徐孝儒闵丽谦（福建省莆田县医院，莆田３５１１００）１９９５年３月～１９９６年３月采用聚合酶链反应（ＰＣＲ）技术对男性尿道炎患者进行砂眼衣原体（ＣＴ）和解脲支原体（ＵＵ）检测，以探讨ＰＣ...     

力平脂治疗老年Ⅱ型糖尿病合并高脂血症的效果观察

力平脂治疗老年Ⅱ型糖尿病合并高脂血症的效果观察徐州医学院第二附属医院（２２１００６）蔡可英南京医科大学第一附属医院（２１００２９）刘超蒋须勤我们使用力平脂治疗老年Ⅱ型糖尿病伴高脂血症取得较好的疗效，不仅降脂作用显著、迅速，而且还可升高高密度脂蛋白胆固...     

同时测定血清和脑脊液NANA含量对脑梗塞及多发性硬化症的临床诊断价值

N-乙酰神经氨酸(NANA)做为神经节苷脂的重要组成成分，参与多种神经活动，但它在缺血性和原发性脱髓鞘疾病中的临床意义还不清楚。本研究试图通过脑梗塞(CI)和多发性硬化症(MS)患者血清和脑脊液NANA含量同时测定，分析NANA在神经系统脱髓鞘疾病中的临床诊断价值。     

益肾生发片的制备及临床应用观察

我院研制的益肾生发片具有疏肝益肾、养血生发的作用,用于斑秃、神经性皮炎、脂溢性皮炎、全秃、普秃之血虚、肝郁、血淤型者疗效显著,现报道如下。1处方组成菟丝子、桑椹、黑芝麻、当归、桑叶、侧柏叶各38.4g,何首乌57.6g,丹参67.2g,枸杞子28.8g,川芎32g。2配制工艺菟丝子、丹     

Rosiglitazone down-regulates lipopolysaccharide-induced expression of CD40 and intercellular adhesion molecule 1 in rat peritoneal mesothelial cells through a NF-κB dependent mechanism

Objective To investigate the effect and mechanism by which PPARγ ligand, rosiglitasone, regulates the expression of CD40 and intercellular adhesion molecule 1 (ICAM-1) in the rat peritoneal mesothelial cells (RPMCs) induced by lipopolysaccharide (LPS). Methods RPMCs were harvested from Sprague-Dawley rat peritoneal cavity and maintained under defined in vitro conditions. The cells were randomly divided into groups as follows: medium, LPS (5 mg/L), LPS (5 mg/L)+BAY11-7085(5 μmol/L, NF-κB inhibitor), rosiglitazone (10 μmol/L or 20 μmol/L, peroxisome proliferator-activated receptor γ activator), LPS (5 mg/L)+rosiglitazone (10 μmol/L)+GW9662 (3 μmol/L, peroxisome proliferator-aetivatcd receptor γ antagonist), and LPS (5 mg/L)+vehicle (DMSO 0.2 ml/L). The expressions of CD40 and ICAM-1 RNA in RPMCs were examined by RT-PCR after 3 hour treatment, and the protein expressions of CD40, ICAM-1, p-NF-κB p65 and p-IκBα were examined by Western blot or immunofluorescence after 24 hour treatment. Results Following treatment with LPS, both the expressions of CD40 and ICAM-1 protein in RPMCs were up-regulated significantly (P<0.05), and the phosphoralation of p65 was increased greatly (1.10±0.17 vs 0.55±0.06, P<0.05). BAY11-7085 (5 μmol/L) significantly decreased the protein expression of p-p65 (0.22±0.11 vs 1.10±0.17, P<0.01), CD40 (0.34±0.02 vs 0.50±0.06, P<0.05) and ICAM-1 (0.35±0.16 vs 0.74±0.03, P<0.05). Pretreated with rosiglitazone for 3 h then added with LPS for 1 h, the levels of p-p65, CD40 and ICAM-1 in RPMCs were significantly decreased compared with those of LPS group (0.77±0.08 vs 0.90±0.10, P相似文献