胃肠道类癌—附8例临床病理分析

目的：探讨胃肠类癌的临床病理表现、诊断、组织形态及免疫组化表达。方法：收集8例胃肠道类癌进行临床、组织病理和免疫组化分析。结果：胃肠道类癌镜下主要有两种形态：典型类癌和不典型类癌。免疫组化均表达嗜铬蛋白突触素、神经元特异性烯铬酶。结论：胃肠道类癌患临床一般出现不同程度的消化道症状。通过内窥镜检查取材活检或以“息肉”行高频电切除后，经病理检查即可确诊。     

围绝经期妇女性激素水平的变化

为使广大妇女能安全的渡过围绝经期，避免或减少围绝经期综合征的发生，提高其生活质量，探讨围绝经期妇女性激素变化与临床表现的关系并及早作出诊断。现对2006年1月～2007年1月来在全市6所三级以上医疗保健机构妇产科就诊的368例45．55岁的妇女进行性激素6项检查，现将结果报告如下。[第一段]     

奥扎格雷钠联合小剂量尿激酶治疗急性脑梗死的疗效观察

目的 观察奥扎格雷钠联合小剂量尿激酶治疗急性脑梗死的疗效.方法 选择颈内动脉系统急性脑梗死患者107例,随机分成2组,治疗组54例,对照组53例.治疗组奥扎格雷纳80mg加入生理盐水250ml静滴,1次/d,连用10d;尿激酶20万U加入生理盐水200ml静滴,1次/d,连用7d.对照组血塞通500mg,曲克芦丁0.6g分别加入生理盐水250ml中静滴,1次/d,连10d.治疗前后监测FG、PLT、PT、APTT、GPT、BUN.结果 治疗组总有效率90.74%,对照组75.47%.治疗后2组间神经功能缺损评分、总有效率有显著性差异,治疗组治疗前后PT、APTT、FG、GPT、BUN无变化.结论 奥扎格雷钠联合小剂量尿激酶治疗急性脑梗死安全有效.     

试论手法之补泻及其辨证应用

本文通过古代文献论述以及现代研究,提出了手法补泻的方向、缓急、轻重、时间、手法和受力部位和特性的六个影响因素,并以以"三因制宜"为纲,从因地、因时、因人的年龄、性别、体质、所患疾病、病情变化、脏腑功能、耐推拿程度以及心量状况的不同等十个方面论述手法之补泻的临床辨证施用.     

情绪性疾病知多少

我们知道，人感染了细菌、病毒会得病，机体受了创伤会发病，饮食不当也会患病，却往往忽视了另一种非常常见，却又不足以引起人们注意的致病因素，这就是不正常的情绪变化，它可能导致很多疾病发生，下面这些疾病皆可由不良的情绪所致。     

Leber先天性黑蒙基因研究进展

Leber先天性黑蒙(LCA)是导致婴幼儿先天性盲的严重遗传性视网膜疾病。近年发现，数种与LCA相关的致病基因，主要包括GUCY2D、RPE65、CRX、AIPL1、RPGRIP1和CRB1，其功能涉及视网膜光电信号的传导、维生素A在视网膜的代谢、光感受器细胞的分化和形态发育、蛋白的转运和分布等。针对RPE65的基因治疗在动物实验中取得了一定的成果，将是未来LCA临床治疗的主要研究方向。本就当前LCA的致病基因及其可能的发病机制、基因治疗等方面的研究进展作一综述。     

优化商品陈列 刷新销售业绩

研究表明：商品陈列面的大小变化、化妆品陈列的高低变化和化妆品的陈列时间等均会影响化妆品店的销售额。首先，商品陈列面的大小变化会引起销售额的变化。如由4个货位减少到2个货位，销售额锐减48％；由3个货位减少到1个货位，销售额锐减68％；由2个货位增加到4个货位，销售额增加40％。所以，在化妆品店的商品陈列中，要加大购买频率较高品种的陈列面，并以大陈列面形成聚焦点，刺激顾客购买。     

血透患者中枸橼酸西地那非的药代动力学及血流动力学变化

患有肾病的男性中ED发病率很高。枸橼酸西地那非是勃起功能障碍的高效治疗药物，严重肾功能不全会使该药清除率下降，但在血透治疗的终末期肾病患者中，该药的药代动力学和血液动力学研究尚未见报导。为了研究血透患者中，该药的药代动力学和血流动力学变化，Grossman EB等人让15例慢性门诊血透维持患者在血透前2h及血透后2h口服单剂西地那非，先服哪一次进行随机分配确定。     

Changes in T .lymphocyte subsets after severe traumatic brain inJury

BACKGROUND： Besides local changes of cranial parenchymal cells, hemorrhage, etc., severe traumatic brain injuries also cause the changes of total body fluid and various functions, and the changes of lymphocytes and T lymphocyte subsets should be paid more attention to. OBJECTIVE： To reveal the changing laws of T lymphocyte subsets after severe traumatic brain injury, and compare with mild to moderate brain injury. DESIGN： A comparative observation. SETTINGS： Department of Neurosurgery, Longgang District Buji People＇s Hospital of Shenzhen City; Central Laboratory of Shenzhen Hospital of Prevention and Cure for Chronic Disease. PARTICIPANTS： All the subjects were selected from the Department of Neurosurgery, Longgang District Buji People＇s Hospital of Shenzhen City from August 2002 to August 2005. Thirty patients with severe brain injury, whose Glasgow coma score （GCS） was ≤ 8 points, were taken as the experimental group, including 21 males and 9 females, aging 16 - 62 years. Meanwhile, 30 patients with mild traumatic brain injury were taken as the control group （GCS ranged 14- 15 points）, including 18 males and 12 females, aging 15 -58 years. All the subjects were in admission at 6 hours after injury, without disease of major organs before injury Informed consents were obtained from all the patients or their relatives. METHODS： （1） The T lymphocytes and the subsets in peripheral blood were detected with immunofluorescent tricolor flow cytometry at l, 3, 7 and 14 days after injury in both groups. （2） The conditions of pulmonary infections were observed at 4 days after injury. The differences of measurement data were compared with the t test. MAIN OUTCOME MEASURES： Changes of T lymphocytes subsets at 1 - 14 days after severe and mild or moderate traumatic injury. RESULTS： Finally, 28 and 25 patients with mild to moderate traumatic brain injury, whereas 25 and 21 patients with severe traumatic brain injury were analyzed at 7 and 14 days respectively, and the missed ones died due to the development of disease. （1） Changes of T lymphocyte subsets： At 1 and 3 days after injury, CD3, CD4, CD8, CD4/CD8 began to decrease, whereas CD8 increased in the experimental group, which were very significantly different from those in the control group （t =2.77 - 3.26, P 〈 0.01）, and began to recover at 7 days, which were significantly different from those in the control group （t = 2.06 - 2.24, P 〈 0.05）, and generally recovered to the normal levels at 14 days （P 〉 0.05）. （2） Conditions of pulmonary infections： At 4 days after injury, the rate of pulmonary infection was significantly different between the experimental group and control group [73% （22/30）, 0, x2=37.29, P 〈 0.01]. CONCLUSION： Patients with severe traumatic brain injury suffer from damages of cellular immune function at early period （within 7 days）, and they are easily to be accompanied by pulmonary infections.