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41.
42.
J.-L. Goëb S. Férel† J. Guetta P. Dutilh E. Dulioust J. Guibert A. Devaux G. Feldmann A. Guedeney P. Jouannet B. Golse 《Annales médico-psychologiques》2006,164(9):781-788
Assisted Reproductive Technologies (ART) come along with important emotional and psychological burden, as well as the physical constraints, for both the woman and her partner. Couples entering ART programs are usually infertile ones, but some specific settings, like serodiscordant couples where the male partner is HIV positive, involving fertile couples. These couples are usually well-adjusted and motivated ones. During the treatments, waiting for the outcome, and the unsuccessful cycles are among the most stressfull experiences. Common reactions are stress, anxiety and depression, but for some couples, the difficulties are so great that they discontinue the program after only one attempt. When parents, the couples usually experience good parenting competencies, and the “precious” children, despite a greater genetic risk, usually have a normal development, but some specific psychological difficulties may arise, that may request a specific help. 相似文献
43.
Louise Hall Simon Hewson 《Journal of Applied Research in Intellectual Disabilities》2006,19(2):204-207
Background In 1995, an unpublished study (S. Hewson & C. Waters) showed that the community links of residents in 11 local National Health Services (NHS) trust houses were meagre, despite the service's stated commitment to community presence and participation. The 1995 study was repeated for the same 11 houses in 2002 to examine whether any changes had occurred. Method A test–retest design, with repeated measures was used, involving, as closely as possible, the same participants at two time points. Community links referred to the time residents spent outside their house, and the time unpaid visitors spent inside the house in the presence of the residents. Results The community links of the people studied were no better in 2002 than in 1995. Conclusions These findings question whether current service provision can deliver policy objectives for social inclusion for people with intellectual disabilities. 相似文献
44.
Dr. Steven A. Curley MD Robert A. Newman PhD Thomas B. Dougherty MD PhD George M. Fuhrman MD Diana L. Stone BS Jeffrey A. Mikolajek CRNA Sal Guercio CCP Ann Guercio CCP C. Humberto Carrasco MD M. Tien Kuo PhD David C. Hohn MD 《Annals of surgical oncology》1994,1(5):389-399
Background: We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in
patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could
be limited after high-dose hepatic arterial infusion (HAI), and (b) the hepatic maximum tolerated dose (MTD) of doxorubicin.
Methods: Ten patients with biopsy-proven HCC were treated with 20-min HAI of doxorubicin (17 total treatments). Two patients were
treated with doxorubicin 60 mg/m2, three patients were treated at 90 mg/m2, and five patients received 120 mg/m2. A newly developed dual-balloon vena cava catheter was advanced from the femoral vein, and the balloons were inflated to
isolate and capture total hepatic venous outflow. The hepatic venous blood was pumped through extracorporeal carbon chemofilters
before return of the blood to the systemic circulation.
Results: Peak systemic doxorubicin levels were an average 85.6% lower than were peak prefilter levels (p<0.01). Because all catheters
were placed percutaneously and because the chemofiltration markedly limited systemic chemotherapy exposure, patients were
discharged 1 day after 16 of the 17 treatments. The hepatic and systemic MTD of doxorubicin in this treatment protocol was
120 mg/m2.
Conclusions: This novel system of complete hepatic venous isolation and chemofiltration limits systemic chemotherapy toxicity and will
allow use of higher doses of chemotherapeutic agents to treat HCC.
The results of this study were presented at the 46th Annual Cancer Symposium of The Society of Surgical Oncology, Los Angeles,
California, March 18–21, 1993. 相似文献
45.
乳酸氧化酶分离纯化的研究 总被引:2,自引:0,他引:2
粪链球菌发酵液经菌体破壁、丙酮分级沉淀、硫酸铵盐析、DEAE-纤维素柱色谱,Sephadex G-150分子筛和 Sephadex A-50柱色谱等分离步骤,制得较纯的乳酸氧化酶,可用于酶盒测定。 相似文献
46.
Demosthenes Katritsis Kenneth A Ellenbogen A John Camm 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2004,6(5):425-432
BACKGROUND: The clinical significance of conduction recurrences in isolated pulmonary veins of patients with atrial fibrillation is not established. METHODS: Twenty-two patients with paoxysmal atrial fibrillation underwent successful pulmonary vein isolation. Six months after the procedure, 14 patients were free of atrial fibrillation. Two of these patients were subjected to repeat mapping of the left superior pulmonary vein. RESULTS: There was recurrence of pulmonary vein to left atrium conduction despite complete lack of symptoms or evidence of recurrent atrial fibrillation. CONCLUSION: Successful pulmonary vein isolation with abolition of paroxysmal atrial fibrillation does not confer permanent disconnection of the pulmonary vein musculature from the left atrium. 相似文献
47.
48.
目的建立简单、有效而稳定的大鼠肝脏Kupffer细胞分离、纯化的实验方法。方法①大鼠肝脏的胶原酶离体灌注;②Percoll液不连续梯度离心分离Kupffer细胞;③选择性贴壁纯化Kupffer细胞;④吞噬墨汁实验、DAB染色,光镜、电镜下观察鉴定Kupffer细胞。结果最终获得的大鼠肝脏Kupffer细胞活性〉90%,纯度为95%,光镜下Kupffer细胞具有较强的贴壁及吞噬碳粒能力,DAB染色呈黄色煎蛋样结构;新分离的Kupffer细胞呈圆形,形态大小一致;2d后,细胞发生伸展,呈多角形或星形。电镜下观察可见典型特点:有伪足及杯口状改变,有丰富的溶酶体和吞噬体。结论本实验建立的大鼠肝脏Kupffer细胞的分离培养方法效果稳定,同时培养的细胞具有良好的生物学性状。 相似文献
49.
Cheryl M. Mccormick Priscilla Kehoe Sandra Kovacs 《International journal of developmental neuroscience》1998,16(3-4)
Repeated isolation of neonatal rats produces persistent changes in physiology and behavior. In Experiment 1, we examined changes in plasma corticosterone (CORT) levels as a possible mechanism for the effects of isolation. Pups that were isolated from their mother and the nest for 1 h per day on postnatal days (PND) 2–9 were compared to control litters of pups that were either nonhandled or handled but not isolated. On PND 2, compared to nonhandled pups, handled pups had elevated CORT levels that returned to baseline levels within 30 to 60 min of return to the home cage. No significant elevation of CORT levels were found in handled pups on PND 9. The CORT levels of isolated pups were over twice those of nonhandled pups on PND 2 and four times those of nonhandled pups on PND 9. In Experiment 2, we investigated whether the increased CORT release in response to isolation on PND 9 was the result of the pups treatment on the previous six days as against an effect of maturation. Plasma CORT levels were measured in rat pups that were either isolated, handled or nonhandled on PNDs 2–8 during the conditions of isolation, handling and nonhandling on PND 9. There were no differences among the groups in basal plasma levels of CORT. Handling on PND 9 did not result in elevated CORT levels in any of the groups. All three groups showed a significant increase in plasma CORT levels after isolation on PND 9. However, the CORT response to isolation of pups previously isolated on PND 2–8 were significantly higher than pups that were either handled or nonhandled on PNDs 2–8. Thus, daily episodes of isolation potentiate the hypothalamic-pituitary-adrenal response to stress. 相似文献
50.