50例甲状腺癌的临床病理分析

甲状腺癌是临床和病理易于误诊的恶性瘤之一,高分化甲状腺癌与甲状腺腺瘤很难鉴别,甲状腺癌的组织学分类和病理诊断标准至今尚未统一。本文根据50例甲状腺癌的临床病理分析,参阅有关文献,对甲状腺癌的诊断标准、鉴别诊断和地方性甲状腺肿与癌的关系进行讨论。     

两种术式治疗甲状腺相关眼病上睑退缩的比较

目的对比两种术式矫正甲状腺相关眼病上睑退缩的临床疗效。方法将22例(32只眼)甲状腺相关眼病上睑退缩患者,随机分为A、B两组。A组11例18只眼采用上睑提肌中央腱膜切断术矫正;B组11例14只眼采用上睑提肌和Muller肌延长术矫正。术后随访6个月,评价其临床疗效。结果所有患者术后自觉症状均明显减轻或消失,A组及B组各自术前与术后疗效相比,均有统计学意义(P<0.01),组间比较无统计学意义(P>0.05)。术后6个月A组有4例6眼,B组有1例1眼上睑回退,经卡方检验,回退率组间比较有统计学意义(P<0.05)。两组均无一只眼过矫。结论两种术式均可有效矫正静止期甲状腺相关眼病的上睑退缩,但上睑提肌和Muller肌延长术回退率低。     

青海玉树健康人甲状腺激素测定

本文对玉树(海拔3700米)正常人58例的甲状腺激素用放射免疫法进行了测定,与西宁地区和平原地区对比,结果说明玉树地区T3、T4值明显或显著低于西宁和平原地区。TSH值又明显或显著高于西宁和平原地区、西宁地区P3、T4和TSH值均明显或显著低于平原。玉树地区藏、汉之间;男、女之间也有一定差异。这可能是高原低气压,缺氧对肝脏代谢的影响,调节甲状腺激素,以求机体对高原坏境的适应。     

Thyroid storm as a cause of loss of consciousness following anaesthesia for emergency Caesarean section

A previously undiagnosed thyrotoxic patient was anaesthetised for an emergency Caesarean section. The recovery period was complicated by an acute thyroid crisis resulting in loss of consciousness following an apparently normal recovery from general anaesthesia.     

血清保存方法对促甲状腺激素结果的影响观察

目的 :观察血清保存方法对促甲状腺激素 (TSH)结果的影响。方法 :将甲状腺功能正常、异常患者共 10份血清 ,采用不同血清量、不同条件分组保存后测定 TSH。结果 :保存方法对 TSH结果有一定的影响。结论 :用于 TSH血清的保存量要多、要密封管口、低温保存。     

硫代葡萄糖甙对碘代谢和甲状腺的影响

猪饲喂８％～１６％英籽饼日粮，平均每日从日粮中摄入９１９．４２～１４１６．０２ｍｇ硫代葡萄糖甙。在连续饲喂１２０天后，其甲状腺肿大，甲状腺滤泡和甲状腺上皮细胞显著增生，细胞质内缺乏分泌颗粒和溶酶体，细胞顶端密集微绒毛；滤泡腔内胶质周边部具有大量吸收空泡，分泌功能旺盛。Ｔ＿４和Ｔ＿４／Ｔ＿３比值明显升高，甲状腺功能亢进。若日粮中增加给碘量和服用解毒剂，猪甲状腺的组织形态学和超微结构接近正常，Ｔ＿４和／Ｔ＿４／Ｔ＿３比值亦趋于正常。     

Ag—NOR计数在区分良恶性甲状腺病变中的意义

随机选择经长期随访证实的滤泡性甲状腺癌和腺瘤各10例,正常甲状腺组织5例作为对照。按Ploton的染色方法和Crocker推荐的计数方法分别计算三组每例各50个细胞的Ag-NOR嗜银颗粒平均数,再算出三组各自的AgNOR均数,经统计学检验三者有极显著性差异。可望成为甲状腺滤泡性肿瘤良恶鉴别的一项辅助指标。     

超声诊断甲状腺腺瘤与单发结节性甲状腺肿的价值

目的　探讨超声在甲状腺腺瘤与单发结节性甲状腺肿鉴别诊断中的价值。方法　对两种疾病的二维及彩色多普勒声像图进行分析并比较。结果　甲状腺腺瘤与单发结节性甲状腺肿比较 ,甲状腺大小、结节大小、结节内回声及周围回声组间差异均无统计学意义 (P >0 .0 5 ) ;结节边缘晕环及结节内部和周边血流信号差异有显著性 (P <0 .0 5 )。结论　单发结节性甲状腺肿易误诊为腺瘤 ,结节边缘晕环及结节内部和周边血流信号对鉴别诊断可提供帮助     

Relation between Estrogen Receptor and Malignancy of Thyroid Cancer

The relationship between the histological grade of dedifferentiation of thyroid cancer and estrogen receptors (ER) was examined immunohistochemically. Thyroid cancers were from postmenopausal females of almost the same mean age (69-73 years old) and within the same period of time (1974–1983). ER immunoreactivity located in the nucleus of the epithelium was found in all 6 well differentiated papillary cancers, and 5 of them (83.3%) showed ER-immunoreactive (ER-IR) cells amounting to 20 or more per visual field (x 100) under a light microscope. Of the 6 cases of poorly differentiated papillary cancer, 5 (83.3%) had 1-19 ER-IR cells per visual field. ER-IR cells were negative in 5 out of 6 cases (83.3%) of anaplastic cancers. Thus, the number of ER-IR cells tended to decrease with the degree of atypism of thyroid cancer (P < 0.001).     

Evaluation of local cerebral glucose utilization and the permeability of the blood-brain barrier in the genetically epilepsy-prone rat

Summary The genetically epileptic-prone rat (GEPR) is a valuable model for the study of gene-linked abnormalities involved in epilepsy. In comparison with normal Sprague-Dawley controls, we found, in GEPRs, a marked depression in local cerebral glucose utilization, widespread throughout the brain. This depression was accompanied by a significant increase of blood-brain barrier permeability and a reduction in regional blood volume. Finally GEPRs showed lower plasma levels of total triiodothyronine than normal controls. One can speculate that alterations in cerebral metabolism and microvascular regulation and thyroid hormone imbalance may be gene-linked factors involved in seizure susceptibility.