正交试验法优选精乌颗粒的提取工艺

目的:优选精乌颗粒的提取工艺。方法:以二苯乙烯苷(2、3、5、4′-四羟基二苯乙烯-2-Oβ--D-葡萄糖苷)的含量及出膏率为考察指标,采用L9(34)正交设计优选提取工艺条件,确定精乌颗粒的最佳提取工艺。结果:A1B2C2即以8倍量水、煎煮2次、2h/次为最佳工艺。结论:优选出的工艺科学合理,可作为该制剂合理开发的依据。     

Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations

Spray drying is an efficient technology for solid dispersion manufacturing since it allows extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to solid API-carrier particles. Solvent evaporation kinetics certainly contribute to formation of amorphous solid dispersions, but also other factors like the interplay between the API, carrier and solvent, the solution state of the API, formulation parameters (e.g. feed concentration or solvent type) and process parameters (e.g. drying gas flow rate or solution spray rate) will influence the final physical structure of the obtained solid dispersion particles. This review presents an overview of the interplay between manufacturing process, formulation parameters, physical structure, and performance of the solid dispersions with respect to stability and drug release characteristics.     

浅谈医疗仪器设备的技术验收

仪器设备的验收是保证医院医疗仪器设备质量的第一步。验收的程序是否有序、完整关系着验收结果是否合格。只有加强医疗设备验收的管理工作,才能促进医院医疗仪器设备的管理工作,维护医院的经济效益。     

Design and In-line Raman Spectroscopic Monitoring of a Protein Batch Crystallization Process

Raman spectroscopy was used to design and monitor a lysozyme protein batch crystallization process in a lab scale study to facilitate the design of a pharmaceutical protein manufacturing process. A D-optimal design that consisted of 18 experiments was performed to elucidate the effect of temperature, concentration of the precipitating agent, time of crystallization, and possible interactions between these three factors on the Raman scattering changes. A polynomial mathematical model was calculated relating the scattering of the lysozyme solutions measured at individual Raman shifts to the significant factors obtained in the previous crystallization experiment. The 2,940-cm⁻¹ band provided the highest correlation values indicative of small prediction errors and good predictive ability for the crystallization model. Raman scattering signals obtained during the experiments were used as input to obtain a response surface for the factors studied and elucidate the relationship between the crystallization process conditions and the crystals obtained. The main factors affecting the crystallization process were the sodium chloride concentration and temperature.     

医疗器械灭菌包装设计的几个基本要求

医疗器械灭菌包装（MDSP）的基本原理及在实践中的实现。     

业务流程重组理论在门诊信息化建设中的应用

文章阐述了业务流程重组和信息技术的关系，并联系实际讨论了如何应用业务流程重组理论进行门诊信息化建设，以及业务流程重组理论在门诊信息化建设中的应用体会。     

试论医院流程化管理形成的基础——过程方法

一些医院采用了流程化方式进行医院管理活动，由于普遍存在着对流程机制、实质内涵以及流程管理认识和操作能力上的不足，因此收到的效果不大。医院流程化管理的基础应是对过程进行的科学规范化的管理，应采用先进的“过程方法”理论和手段对现有的医院流程内容进行完善和改进，切实提高组织流程化管理水平。     

农村城市化进程中乡村医师的管理和发展

上海市宝山区在农村城市化进程中以乡村医师管理和发展的实践研究，分析了乡村医师的现状与问题，提出了农村城市化进程中乡村医师管理与发展的若干对策。     

略论医用高值耗材条形码管理

从医用高值耗材的管理入手,立足于国内医院高值耗材管理的现状,深刻分析了高值耗材采用条形码管理的必要性。针对医院管理的需求,在高值耗材管理流程再造方面进行了探索,对于解决目前医院普遍存在的高值耗材管理的瓶颈问题具有深刻的现实意义,并为构建政府与医疗机构"零距离"的不良事件快速反应和危机追溯机制提供了基础。     

腰椎间盘突出髓核摘除术住院标准流程构建研究

随机选取腰椎间盘突出髓核摘除术患者50例,通过对诊疗资料的现状分析,以循证医学和专家论证为基础,采用流程重组技术和主次因素分析法,制定了该病种的住院标准流程。该标准流程对于缩短平均住院日、提高医疗服务质量有积极的实践意义。