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81.
Objective
Participation in evidenced‐based arthritis self‐management programs (SMPs) has not been well documented. The purpose of this study was to investigate the participation rate and participant characteristics in a closed cohort of subjects in a geographic region where arthritis SMPs have been offered multiple times and continuously for 2 decades.Methods
Data were from osteoarthritis (OA) and rheumatoid arthritis subjects participating in the Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS) who resided in the San Francisco (SF) Bay area who had responded to questions about ever participating in an SMP. Differences between participants and nonparticipants were examined by t‐tests and chi‐square tests.Results
Questions added to the Health Assessment Questionnaire were returned by 1,176 patients; 618 resided in the SF Bay area. Of the SF Bay area sample, 41.9% had participated in an SMP. Small group SMPs, which had been offered multiple times, in diverse settings, continuously over the past 2 decades, were attended by the highest proportion (28%) of participants. Characteristics of participants and nonparticipants in the SF Bay area were similar (~70 years old, 15 years of education, and the majority had OA [~72%]). However, a higher proportion of participants were white (88% versus 82%; P = 0.046) and female (82% versus 73%; P < 0.05).Conclusion
When arthritis SMPs were offered multiple times in diverse settings and continuously over many years, >40% of the cohort was reached. More research is needed with larger samples and different geographic regions to identify participation rates in more diverse populations. 相似文献82.
83.
J. H. M. Blom F. J. W. Ten Kate F. H. Schroeder R. O. van der Heul 《Urological research》1990,18(2):93-99
Summary At present there are several grading systems for prostatic carcinoma. Most are difficult to reproduce. An objective method of grading seems to be necessary and could make comparisons between various groups of patients easier and grading more reliable.In the present study morphometrically estimated nuclear size and variation in nuclear size are matched with the survival rates of 207 patients who underwent total perineal prostatetomy for cancer. On the basis of morphometrically estimated variation in nuclear size the patients could be divided into two groups with significantly differing survival rates. In this way it was possible to split the group of patients with grade 2 carcinoma (Mostofi's grading system) into two groups of patients with significantly different survival rates. The survival rates in these two groups did not differ significantly from those in the patients with Grade 1 and Grade 3 tumors respectively.The results are discussed in the light of the recent literature on the subject. Morphometry seems to be a valuable tool in grading prostatic cancer. 相似文献
84.
强化输血管理保障安全用血 总被引:10,自引:0,他引:10
目的 探讨强化输血管理 ,保障安全用血的有效措施。方法 ①强化法制观念 ;②完善管理制度 ;③提高技术水平 ;④协调供需矛盾 ;⑤健全组织完善设施 ;⑥加强宣教合理用血。结果 完善了科室的管理 ,杜绝了输血工作的隐患 ,减少了医患矛盾 ,提高了输血的诊治水平。结论 保障了输血安全 ,使输血工作走上科学、规范的轨道 ,收到良好的社会效益 相似文献
85.
上海社区老年人用药安全及影响因素分析 总被引:11,自引:0,他引:11
目的:了解上海社区老年人群的用药安全情况及其影响因素,方法:以整群抽样的方法抽取上海市黄浦区两个居民委员会2985名60岁以上的居民进行问卷调查,了解其疾病和用药情况,用药反应,对安全用药的知识,态度,行为,以及影响其用药行为的因素,结果:被调查中高血压、冠心病、消化系统疾病和呼吸系统疾病的患病率分别为35.93%、10.67%、5.70%和3.71%。抗高血压药,心脑血管病药,消化系统疾病和呼吸系统疾病的患病率分别为35.93%、10.67%、5.70%和3.71%,抗高血压药、心脑血管病药,消化系统药和抗生素的使用率分别为31.72%、16.20%、2.43%和2.11%,过去30天内,51.33%的被调查用过药物,用药不良反应发生率为2.06%,对用药安全的正确知识,态度,行为率分别为71.62%、69.39%及60.67%,影响药物选择的因素中医生占88.19%,结论:老年人的用药安全仍存在问题,有待改进,医生是影响老年人药选择的最主要因素。 相似文献
86.
Quality of life research in patients with rectal cancer: traditional approaches versus a problem-solving oriented perspective 总被引:4,自引:0,他引:4
M. Koller W. Lorenz 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1998,383(6):427-436
The present paper critically appraises two recent overviews of the literature on rectal cancer and quality of life (QL).
These reviews focus on the Anglo-American literature, largely neglect research from other countries, and provide little stimulus
regarding future research directions. As an alternative perspective we propose the concept of problem-solving oriented QL
research. The major theme is that the QL concept must be integrated into the clinical arena. To begin with, QL researchers
must make themselves understandable. We outline several ways in which this can be achieved: (a) placing QL in a broader concept
together with outcomes that are more familiar to clinicians; (b) depicting individual patients in the form of QL profiles;
(c) clarifying the psychosocial/clinical correlates of particular QL scores of interest; and (d) conducting studies with a
definitive practical goal in mind and integrating practitioners and patients into the study group. We illustrate the feasibility
of such a research program by performance data from our Marburg-Biedenkopf field trial. Pursuing an ambitious research strategy
that integrates experimental and applied research, the QL movement will have the chance to show that it is not merely l'art pour l'art, but indeed is beneficial to society.
Received: 28 September 1998 / Accepted: 14 October 1998 相似文献
87.
K. E. Tomaszewski 《Comparative Haematology International》1993,3(2):67-70
The pharmaceutical industry performs safety studies in animals to underwrite administration of new chemical entities to man. Early clinical evaluation of drugs in volunteers is performed, generally, using highdose acute studies in rodents and 1-month repeat dose studies in one rodent species and one non-rodent species as a basis for risk assessment. Results from the 1-month toxicology studies enable a ceiling for initial clinical doses to be set and give some indication of the major target organs for toxicity. Extrapolation of these results to man helps determine the preliminary safety endpoints, including clinical chemistry parameters, for use in early clinical studies in man.Originally presented at ECCP 93. 相似文献
88.
I. O. Skalpe J. F. Bonneville P. Grane C. Gyldenstedt B. Otto D. T. Kristoffersen M. G. Svaland 《European radiology》1998,8(6):1054-1057
The purpose of this study was to evaluate and compare the radiographic efficacy and safety of iodixanol (Visipaque; 270 and
320 mg I/ml) and iohexol (Omnipaque; 300 mg I/ml) in myelography. The study was randomized, double-blind and comparative including
398 patients from five European university clinics. The radiographic visualisation was evaluated as poor, good or excellent.
Adverse events were recorded by interviewing the patients after the myelography, and each patient was given a questionnaire
to be returned after 1 week. In cervical myelography with cervical puncture more films with excellent quality was obtained
after iodixanol 320 mgI/ml compared with iohexol 300 mgI/ml (p = 0.009). Also in lumbar myelography iodixanol 320 mgI/ml compared favourably with iohexol 300 mgI/ml (p = 0.006). The most frequent adverse event was headache, which occurred in 5–35 % of patients during the first 24 h and in
19–61 % within the first 7 days, depending on the centre. There was no difference in frequency and severity of the adverse
effects between the contrast media.
Received 13 March 1997; Revision received 29 December 1997; Accepted 5 January 1997 相似文献
89.
Jack A. Friedland M.D. William M. Jacobsen M.D. Sarvam TerKonda M.D. 《Aesthetic plastic surgery》1996,20(6):453-462
Surgical rejuvenation of the upper face involves the correction of excess and lax forehead, eyelid, and periorbital skin. Improving the appearance by correcting the effects of aging involves a combination of blepharoplasty and open coronal foreheadplasty. Many surgeons and several reports question the safety of both procedures being performed concomitantly. The difficulty arises in precisely balancing the skin excision from the frontal forehead and upper eyelid areas. Over-resection of skin may result in incomplete closure of the eyelid and dry-eye syndrome, while an inadequate resection may produce a poor aesthetic result. There is no large series that documents the safety and effectiveness of these two procedures being performed concomitantly. Furthermore, with the recent and rapid development of complex multiplanar endoscopic facial rejuvenation techniques, the basic open forehead-plasty has become increasingly overlooked as a legitimate, efficacious technique for rejuvenation of the upper face. The technique utilized in this series is presented in detail. The consistently excellent results obtained satisfy the aesthetic goals of patients as well as the goals of surgeons, and suggest a renewed interest in the technique based upon its simplicity and easily reproducible results. 相似文献
90.
基于FAERS数据库挖掘安全警戒信号,分析评估地舒单抗潜在不良反应信号,为其临床使用提供一定参考依据。方法 通过Openvigil 2.1访问 FAERS 数据库,将地舒单抗作为主要药物,检索自该药首次上市时间(2010年5月—2021年9月)的数据,获得与地舒单抗相关的不良事件报告记录。使用报告比值比法(ROR)和贝叶斯置信度递进神经网络法(BCPNN)筛选地舒单抗安全警戒信号,挖掘潜在的不良反应,并通过工具BioPortal对不良事件信号挖掘结果进行系统分类,通过判断信号间置信区间的变化,发现与药物不良事件关联性较大的信号。结果 从FAERS数据库中收集到270503份不良反应事件(ADE)报告,根据ROR法和BCPNN法共得到343个不良事件信号,通过信号间同义合并、剔除与药物无关的信号后,得到316个不良事件信号。地舒单抗的不良事件系统分类主要为肌肉骨骼和结缔组织疾病、医学检查、胃肠道疾病。FAERS数据库的信号挖掘结果发现,高风险且说明书中未收录的安全警戒信号包括颞下颌关节综合征、下颌脓肿、雌激素缺乏症、血液甲状旁腺激素增加,计算高风险信号的置信区间显示颞下关节综合征较有可能发展成为新的不良反应;另外,也发现种植体周围炎为具有临床意义的可疑警戒信号,但有待进一步观察研究。结论 基于FAERS数据库的信号挖掘结果提示临床应规范使用地舒单抗,治疗期间需警惕患者是否出现颞下颌关节综合征、下颌脓肿、雌激素缺乏症、血液甲状旁腺激素增加等不良反应事件,以便尽早发现尽早处理,从而有效降低临床用药风险 相似文献