全文获取类型
收费全文 | 23435篇 |
免费 | 2929篇 |
国内免费 | 319篇 |
专业分类
耳鼻咽喉 | 169篇 |
儿科学 | 915篇 |
妇产科学 | 217篇 |
基础医学 | 2350篇 |
口腔科学 | 1715篇 |
临床医学 | 1592篇 |
内科学 | 4671篇 |
皮肤病学 | 691篇 |
神经病学 | 1965篇 |
特种医学 | 347篇 |
外国民族医学 | 3篇 |
外科学 | 1723篇 |
综合类 | 1842篇 |
现状与发展 | 6篇 |
预防医学 | 4247篇 |
眼科学 | 553篇 |
药学 | 928篇 |
5篇 | |
中国医学 | 632篇 |
肿瘤学 | 2112篇 |
出版年
2024年 | 40篇 |
2023年 | 511篇 |
2022年 | 602篇 |
2021年 | 1288篇 |
2020年 | 1121篇 |
2019年 | 1076篇 |
2018年 | 1072篇 |
2017年 | 1005篇 |
2016年 | 956篇 |
2015年 | 973篇 |
2014年 | 1422篇 |
2013年 | 1846篇 |
2012年 | 1106篇 |
2011年 | 1324篇 |
2010年 | 1049篇 |
2009年 | 1078篇 |
2008年 | 1111篇 |
2007年 | 1028篇 |
2006年 | 950篇 |
2005年 | 780篇 |
2004年 | 747篇 |
2003年 | 711篇 |
2002年 | 658篇 |
2001年 | 524篇 |
2000年 | 331篇 |
1999年 | 306篇 |
1998年 | 316篇 |
1997年 | 355篇 |
1996年 | 286篇 |
1995年 | 255篇 |
1994年 | 212篇 |
1993年 | 180篇 |
1992年 | 193篇 |
1991年 | 183篇 |
1990年 | 155篇 |
1989年 | 145篇 |
1988年 | 120篇 |
1987年 | 102篇 |
1986年 | 108篇 |
1985年 | 83篇 |
1984年 | 57篇 |
1983年 | 61篇 |
1982年 | 46篇 |
1981年 | 45篇 |
1980年 | 43篇 |
1979年 | 25篇 |
1978年 | 18篇 |
1977年 | 24篇 |
1976年 | 16篇 |
1974年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 140 毫秒
11.
Whitney S. Brandt Wanpu Yan Jian Zhou Kay See Tan Joseph Montecalvo Bernard J. Park Prasad S. Adusumilli James Huang Matthew J. Bott Valerie W. Rusch Daniela Molena William D. Travis Mark G. Kris Jamie E. Chaft David R. Jones 《The Journal of thoracic and cardiovascular surgery》2019,157(2):743-753.e3
Objective
Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non–small cell lung cancer has not been extensively studied.Methods
Patients with cT2-4N0-1M0 non–small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan–Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching.Results
In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response.Conclusions
Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non–small cell lung cancer who undergo complete surgical resection. 相似文献12.
13.
14.
15.
Jae Yun Ahn Jung Bae Park Sungbae Moon Jae Wan Cho Dong Ho Park 《Ophthalmic epidemiology》2020,27(2):105-114
ABSTRACT
Purpose
Work-related eye injuries have been reported with a variety of epidemiologic and clinical characteristics. We aimed to identify epidemiologic characteristics of work-related eye injuries and risk factors associated with severe injury in a large metropolitan city. 相似文献16.
Maaike van Gerwen MD Naomi Alpert MS Raja Flores MD Emanuela Taioli MD PhD 《American journal of industrial medicine》2020,63(2):115-120
The association between asbestos exposure, mainly in occupational settings, and malignant mesothelioma has been well established; this has prompted several countries to establish mesothelioma epidemiologic surveillance programs often at the request of national agencies. This review compares currently existing mesothelioma registries worldwide to develop a concept model for a US real-time case capture mesothelioma registry. Five countries were identified with a mesothelioma specific registry, including Italy, France, UK, Australia, and South Korea. All, except the UK, used interviews to collect exposure data. Linkage with the national death index was available or was in future plans for all registries. The registries have limited information on treatment, quality of life, and other patient-centered outcomes such as symptoms and pain management. To thoroughly collect exposure data, “real-time” enrollment is preferable; to maximize the capture of mesothelioma cases, optimal coverage, and a simplified consent process are needed. 相似文献
17.
《Clinical neurophysiology》2021,132(12):3104-3115
ObjectiveWe aimed to establish an objective neurophysiological test protocol that can be used to assess the somatosensory nervous system.MethodsIn order to assess most fiber subtypes of the somatosensory nervous system, repetitive stimuli of seven different modalities (touch, vibration, pinprick, cold, contact heat, laser, and warmth) were synchronized with the electroencephalogram (EEG) and applied on the cheek and dorsum of the hand and dorsum of the foot in 21 healthy subjects and three polyneuropathy (PNP) patients. Latencies and amplitudes of the modalities were assessed and compared. Patients received quantitative sensory testing (QST) as reference.ResultsWe found reproducible evoked potentials recordings for touch, vibration, pinprick, contact-heat, and laser stimuli. The recording of warm-evoked potentials was challenging in young healthy subjects and not applicable in patients. Latencies were shortest within Aβ-fiber-mediated signals and longest within C-fibers. The test protocol detected function loss within the Aβ-fiber and Aδ-fiber-range in PNP patients. This function loss corresponded with QST findings.ConclusionIn this pilot study, we developed a neurophysiological test protocol that can specifically assess most of the somatosensory modalities. Despite technical challenges, initial patient data appear promising regarding a possible future clinical application.SignificanceEstablished and custom-made stimulators were combined to assess different fiber subtypes of the somatosensory nervous system using modality-specific evoked potentials. 相似文献
18.
目的:分析宣威地区与非宣威地区的肺癌临床流行病学与病理特征。方法:以云南省肿瘤医院(昆明医科大学第三附属医院)2015年3月至2015年5月手术治疗的肺癌患者为研究对象,共295例,收集患者相关信息。将其分为宣威地区、非宣威地区进行统计。对患者的临床资料进行回顾性分析,包含病理类型、年龄、性别、吸烟史等。结果:宣威地区、非宣威地区肺癌患者男女比例为1.19∶1和1.69∶1。宣威地区患者平均年龄为[53.41±8.74(34~85)]岁,中位年龄53岁。非宣威地区肺癌患者平均年龄为[58.68±8.63(38~78)]岁,中位年龄59岁。宣威地区肺癌高发年龄为40~59岁段。宣威地区I期肺癌患者占比、T1期肺癌患者占比、N0期肺癌患者占比均高于非宣威地区。宣威地区男性腺癌鳞癌比远高于非宣威地区,差异有显著统计学意义。结论:宣威地区女性肺癌发病率更高,发病年龄更趋年轻化,腺癌比例高,吸烟与宣威地区男性腺癌高发关系不密切。 相似文献
19.
In China, colorectal cancer (CRC) ranked fourth and fifth in the highest incidence and mortality rates of all malignancies in 2018, respectively. Although these rates are below the world average, China placed first worldwide in the number of new CRC cases and CRC-related deaths because of its comparatively large population. This disease represents a threat to the health of population and incurs a heavy economic burden on the society and individuals. CRC has various risk factors, including age, sex, lifestyle, genetic factors, obesity, diabetes, gut microbiota status, and precancerous lesions. Furthermore, incidence and mortality rates of CRC are closely related to socioeconomic development levels, varying according to regional and population characteristics. Prevention is the main strategy to reduce incidence and mortality rates of CRC. This can be achieved through strategies stimulating lifestyle changes, healthy diet habits, and early screening for high-risk individuals. To reduce the burden of CRC, public health officials should promote prevention and management of modifiable risk factors through national policies. The rising incidence and mortality rates of CRC in China may be timely curbed by clarifying specific epidemiological characteristics, optimizing early screening strategies, and strictly implementing diagnosis and treatment guidelines. Thus, this study aimed to collect and report the current research status on epidemiology and risk factors of CRC in China. 相似文献
20.