VMware医用虚拟桌面优化及性能监控策略

随着桌面虚拟化应用的日趋广泛，对桌面的性能和安全性的考虑也变得非常重要。本文根据虚拟桌面实际使用环境，提出并实施了虚拟桌面模板优化以及监测桌面的性能和安全防护策略，有效提高了桌面的连接效率和运行的稳定性。     

浅谈可持续发展的临床科研数据平台建设

医学发展离不开大量临床经验的积累和总结,优秀的临床工作平台可以保障提供足量的病例,然而临床科研所需要的规范化数据还需要遵循科研的标准从海量的临床数据信息中筛选提取。单纯依靠个人的收集往往受其能力和时间限制不能尽善尽美,并且容易形成数据孤岛,不利于平台的持续发展和科研人才的培养效率。可持续发展的临床科研数据平台是医学科研创新和人才培养的基础,文章仅以四川大学华西口腔医院唇腭裂外科科研数据平台建设为例,从实例出发,详细介绍了如何建立临床科研数据平台以及如何保证其可持续性发展,旨在抛砖引玉,为更多可持续发展的临床科研平台建设提供参考。     

基于数据挖掘对治疗口疮的成方制剂的用药规律分析*

目的分析治疗口疮的成方制剂的剂型、功能主治、组方用药规律及核心组合，为临床治疗口疮的辨证用药及新药研发提供参考。方法 收集《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药成方制剂》)、《中华人民共和国药典：2015年版》(以下简称2015年版《中国药典》)中治疗口疮的成方制剂的名称、处方、剂型、功能与主治，录入Microsoft Excel及中医传承辅助平台(V2.5)，统计用药频次；运用Apriori算法及关联规则对处方核心组合进行统计分析(支持度为10%，置信度100%)；采用熵聚类算法统计2-3个不同成分间的关联系数(支持度为8，惩罚度为2)；根据无监督的熵层次聚类法提取内在核心组合和新方组合。结果 挖掘得出86种成方制剂及其处方，以丸剂、散剂、片剂等多见，包含药物148味，使用频次较高为冰片、甘草、大黄、黄芩等，药物四气五味以苦寒为主，主要归肺胃心脾经，治疗证型较多为热毒炽盛证、热毒攻喉证等，常用核心配伍包括“黄芩-大黄”“黄连-甘草”等，挖掘得出新方组合“珍珠-川贝母-灯心草-天花粉-没药”等4首。结论 利用数据挖掘分析治疗口疮的成方制剂的组方规律，由核心药物组合成新方，可为临床辨证使用及研发治疗口疮成方制剂、新药提供依据和参考。     

公共卫生突发事件应急虚拟平台体系建设

介绍国内外公共卫生突发事件应急管理情况，指出我国公共卫生应急平台体系处在成长阶段，存在诸多问题。从建设需求和内容方面对虚拟平台体系建设进行理论分析，从数据收集、数据分析、预测决策提出几方面介绍其模型建构，最后对未来发展方向进行展望。     

In vivo cellular reactions to different biomaterials—Physiological and pathological aspects and their consequences

Biomaterials are widely used in guided bone regeneration (GBR) and guided tissue regeneration (GTR). After application, there is an interaction between the host immune system and the implanted biomaterial, leading to a biomaterial-specific cellular reaction. The present review focuses on cellular reactions to numerous biomaterials in vivo with consideration of different implantation models and microenvironments in different species, such as subcutaneous implantation in mice and rats, a muscle model in goats and a femur model in rabbits. Additionally, cellular reactions to different biomaterials in various clinical indications within the oro-maxillofacial surgical field were considered. Two types of cellular reactions were observed. There was a physiological reaction with the induction of only mononuclear cells and a pathological reaction with the induction of multinucleated giant cells (MNGCs). Attention was directed to the frequently observed MNGCs and consequences of their appearance within the implantation region. MNGCs have different subtypes. Therefore, the present review addresses the different morphological phenotypes observed within the biomaterial implantation bed and discusses the critical role of MNGCs, their subtypes and their precursors as well as comparing the characteristics and differences between biomaterial-related MNGCs and osteoclasts. Polymeric biomaterials that only induced mononuclear cells underwent integration and maintained their integrity, while polymeric biomaterials that induced MNGCs underwent disintegration with material breakdown and loss of integrity. Hence, there is a question regarding whether our attention should be directed to alternative biological concepts, in combination with biomaterials that induce a physiological mononuclear cellular reaction to optimize biomaterial-based tissue regeneration.     

自控镇痛泵联合微信管理平台对癌症晚期患者生活质量的影响

目的探讨自控镇痛泵联合微信管理平台对提高癌症晚期患者生活质量的影响。方法选择2016年6月~2017年6月台州恩泽医疗中心(集团)路桥医院肿瘤科105例癌症晚期患者,根据居家治疗情况分为对照组、观察组1和观察组2,各35例,对照组采用盐酸曲马多缓释片口服,采用电话随访;观察组1采用居家自控静脉镇痛泵治疗,采用电话随访;观察组2采用居家自控静脉镇痛泵治疗,采用微信管理平台进行管理;比较三组疼痛评分、心理状态和生活质量。结果出院后1个月三组疼痛评分比较有显著差异(P0.05),观察组2和观察组1显著低于对照组(P0.05);三组心理状态比较有显著差异(P0.05),观察组2显著低于观察组1和对照组(P0.05),而观察组1和对照组无显著差异(P0.05);三组生活质量比较,食欲、睡眠、心理承受能力、自理能力、自身对疾病的认识方面,差异有统计学意义(P0.01);观察组2显著高于观察组1(P0.01),而观察组1与对照组无显著性差异(P0.05)。结论自控镇痛泵联合微信管理平台对癌症晚期患者居家治疗,能显著减轻疼痛,改善心理状态,提高生活质量。     

Immunological implications of diverse production approaches for Chikungunya virus-like particle vaccines

Chikungunya virus (CHIKV), an arbovirus from the Alphavirus genus, causes sporadic outbreaks and epidemics and can cause acute febrile illness accompanied by severe long-term arthralgias. Over 20 CHIKV vaccine candidates have been developed over the last two decades, utilizing a wide range of vaccine platforms, including virus-like particles (VLP). A CHIKV VLP vaccine candidate is among three candidates in late-stage clinical testing and has potentially promising data in nonclinical and clinical studies exploring safety and vaccine immunogenicity. Despite the consistency of the CHIKV VLP structure, vaccine candidates vary significantly in protein sequence identity, structural protein expression cassettes and their mode of production. Here, we explore the impact of CHIKV VLP coding sequence variation and the chosen expression platform, which affect VLP expression yields, antigenicity and overall vaccine immunogenicity. Additionally, we explore the potential of the CHIKV VLP platform to be modified to elicit protection against other pathogens.     

基于“工作过程”导向和“课程中心”平台的小儿推拿案例式教学

分析小儿推拿的临床现状,提出基于＂工作过程＂导向的课程观,注重以工作任务为中心设计和组织教学内容,在学校教学网络＂课程中心＂平台的辅助下采用案例式教学法,有利于激发学生的学习动机,提高学生自主学习能力,加强临床思维和实践能力,并且在教学中能够充分发挥教师的专业知识和人文精神,对深化中医临床课程的改革具有一定的探索意义。     

中西医结合序贯治疗支气管哮喘64例疗效观察

目的：观察中西医结合序贯治疗对支气管哮喘患者的临床疗效。方法将128例支气管哮喘患者随机分为观察组与对照组,均分发作期、缓解期、稳定期三期序贯治疗。对照组64例予西医常规治疗,观察组64例在对照组基础上配合中药,应用中西医结合疗法,每一期疗程结束评价疗效。结果观察组在发作期病情平均缓解时间,以及肺功能指标、症状体征积分、临床总有效率、1年内复发率等方面与对照组比较,差异有统计学意义（P ﹤0.05,P ﹤0.01）。结论中西医结合序贯疗法能有效改善哮喘患者肺功能,临床近期、远期疗效高,复发率低,提高患者生活质量,值得推广应用。     

借助私有云技术构建HIS自助管理平台

利用云技术搭建自助管理平台,以提高服务质量为目的,加速医院信息化建设。让临床护理工作与行政审批制度分离,使医务人员能全身心投入到医疗工作中。同时开发基于安卓系统的移动客户端来进行审批验证,保障患者住院过程中的流畅性和完整性。为科室无人坚守服务打下了基础,增强临床用户的信息化体验,管理平台作为HIS应用的补充也可以维护医护工作站日常出现的问题。