全文获取类型
收费全文 | 74254篇 |
免费 | 5489篇 |
国内免费 | 1945篇 |
专业分类
耳鼻咽喉 | 460篇 |
儿科学 | 1051篇 |
妇产科学 | 683篇 |
基础医学 | 8661篇 |
口腔科学 | 1193篇 |
临床医学 | 7286篇 |
内科学 | 7101篇 |
皮肤病学 | 406篇 |
神经病学 | 9299篇 |
特种医学 | 2240篇 |
外国民族医学 | 2篇 |
外科学 | 4872篇 |
综合类 | 12652篇 |
现状与发展 | 7篇 |
一般理论 | 4篇 |
预防医学 | 11845篇 |
眼科学 | 780篇 |
药学 | 8040篇 |
106篇 | |
中国医学 | 2577篇 |
肿瘤学 | 2423篇 |
出版年
2024年 | 145篇 |
2023年 | 1075篇 |
2022年 | 1580篇 |
2021年 | 2982篇 |
2020年 | 2804篇 |
2019年 | 2167篇 |
2018年 | 2119篇 |
2017年 | 2156篇 |
2016年 | 2421篇 |
2015年 | 2448篇 |
2014年 | 4899篇 |
2013年 | 5379篇 |
2012年 | 4718篇 |
2011年 | 5129篇 |
2010年 | 4012篇 |
2009年 | 3809篇 |
2008年 | 3981篇 |
2007年 | 3669篇 |
2006年 | 3316篇 |
2005年 | 2840篇 |
2004年 | 2333篇 |
2003年 | 2088篇 |
2002年 | 1610篇 |
2001年 | 1373篇 |
2000年 | 1169篇 |
1999年 | 968篇 |
1998年 | 970篇 |
1997年 | 923篇 |
1996年 | 773篇 |
1995年 | 720篇 |
1994年 | 703篇 |
1993年 | 605篇 |
1992年 | 572篇 |
1991年 | 566篇 |
1990年 | 450篇 |
1989年 | 408篇 |
1988年 | 421篇 |
1987年 | 399篇 |
1986年 | 355篇 |
1985年 | 487篇 |
1984年 | 411篇 |
1983年 | 264篇 |
1982年 | 275篇 |
1981年 | 250篇 |
1980年 | 237篇 |
1979年 | 155篇 |
1978年 | 142篇 |
1977年 | 126篇 |
1976年 | 89篇 |
1974年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 62 毫秒
51.
随着我国医疗机构临床药师队伍的不断壮大,其在医疗服务中发挥着越来越重要的作用,对其工作进行绩效考核也是当今医疗领域的重要内容。以现有文献为基础,对国内外临床药师绩效考核体系进行分析,发现现有体系可分为为基于临床药师职责、基于临床药师业务流程、国外临床药师绩效考核体系三个方面;通过结合医疗机构的实际情况对现有绩效考核体系进行分析,发现存在考核指标和标准确定困难、考核难以做到实时性和延续性等问题,并针对这些问题提出清晰职责定位、重视临床药师价值体现等修改说明。 相似文献
52.
Ana M. Gómez Angelica Imitola Diana Henao Maira García-Jaramillo Marga Giménez Clara Viñals Bruno Grassi Mariana Torres Isabella Zuluaga Oscar Mauricio Muñoz Martin Rondón Fabián León-Vargas Ignacio Conget 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(1):267-272
Background and aimsDespite using sensor-augmented pump therapy (SAPT) with predictive low-glucose management (PLGM), hypoglycemia is still an issue in patients with type 1 Diabetes (T1D). Our aim was to determine factors associated with clinically significant hypoglycemia (<54 mg/dl) in persons with T1D treated with PLGM-SAPT.Methodology: This is a multicentric prospective real-life study performed in Colombia, Chile and Spain. Patients with T1D treated with PLGM-SAPT, using sensor ≥70% of time, were included. Data regarding pump and sensor use patterns and carbohydrate intake from 28 consecutive days were collected. A bivariate and multivariate Poisson regression analysis was carried out, to evaluate the association between the number of events of <54 mg/dl with the clinical variables and patterns of sensor and pump use.Results188 subjects were included (41 ± 13.8 years-old, 23 ± 12 years disease duration, A1c 7.2% ± 0.9). The median of events <54 mg/dl was four events/patient/month (IQR 1–10), 77% of these events occurred during day time. Multivariate analysis showed that the number of events of hypoglycemia were higher in patients with previous severe hypoglycemia (IRR1.38; 95% CI 1.19–1.61; p < 0.001), high glycemic variability defined as Coefficient of Variation (CV%) > 36% (IRR 2.09; 95%CI 1.79–2.45; p < 0.001) and hypoglycemia unawareness. A protector effect was identified for adequate sensor calibration (IRR 0.77; 95%CI 0.66–0.90; p:0.001), and the use of bolus wizard >60% (IRR 0.74; 95%CI 0.58–0.95; p:0.017).ConclusionIn spite of using advanced SAPT, clinically significant hypoglycemia is still a non-negligible risk. Only the identification and intervention of modifiable factors could help to prevent and reduce hypoglycemia in clinical practice. 相似文献
53.
54.
55.
56.
57.
Jungmi Jun 《Ethnicity & health》2020,25(7):960-981
ABSTRACT Objectives: This paper is an examination of cancer/health communication factors (i.e. cancer/health information seeking, patient-provider communication (PPC), cancer screening information from providers) and screening for breast and cervical cancer among Asian Americans and five Asian ethnic groups (Chinese, Filipinos, Japanese, Koreans, Vietnamese) in comparison to Whites. Additionally, the relationship between cancer/health communication disparity and cancer screening gaps between Asian Americans and Whites was investigated. Design: Data comes from a nationally representative sample of 2011–2014 Health Information National Trends Surveys (HINTS). Results: Asian Americans and most Asian ethnic-groups reported significantly lower rates of cancer/health information seeking and lower evaluations for PPC as compared to Whites, though differences within Asian ethnic groups were observed (Koreans’ greater cancer/health information seeking, Japanese’ higher PPC evaluation). When the cancer/health communication factors were controlled, Asian Americans’ odds of cancer screening were increased. Especially, Asian Americans’ odds of adhering to the breast cancer screening guideline became nearly 1.4 times greater than Whites. Conclusion: This research demonstrates that health organizations, providers, and Asian American patients’ collaborative efforts to increase the access to quality cancer information, to make culturally competent but straightforward screening recommendations, and to practice effective communication in medical encounters will contribute to diminishing cancer disparities among Asian Americans. 相似文献
58.
59.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217
60.
《Journal of pharmaceutical sciences》2019,108(10):3425-3433
This study aimed at evaluating how encapsulation in a regular nanocarrier (NC) (providing extended circulation time) or in a brain-targeting NC (providing prolonged circulation time and increased brain uptake) may influence the therapeutic index compared with the unformulated drug and to explore the key parameters affecting therapeutic performance using a model-based approach. Pharmacokinetic (PK) models were built with chosen PK parameters. For a scenario where central effect depends on area under the unbound brain concentration curve and peripheral toxicity relates to peak unbound plasma concentration, dose-effect and drug-side effect curves were constructed, and the therapeutic index was evaluated. Regular NC improved the therapeutic index compared with the unformulated drug due to reduced peripheral toxicity, while brain-targeting NC enhanced the therapeutic index by lowering peripheral toxicity and increasing central effect. Decreasing drug release rate or systemic clearance of NC with drug still encapsulated could increase the therapeutic index. Also, a drug with shorter half-life would therapeutically benefit more from a NC encapsulation. This work provides insights into how a NC for brain delivery should be optimized to maximize the therapeutic performance and is helpful to predict if and to what extent a drug with certain PK properties would obtain therapeutic benefit from nanoencapsulation. 相似文献