Methods for identifying subject‐specific abnormalities in neuroimaging data

Algorithms that are capable of capturing subject‐specific abnormalities (SSA) in neuroimaging data have long been an area of focus for diverse neuropsychiatric conditions such as multiple sclerosis, schizophrenia, and traumatic brain injury. Several algorithms have been proposed that define SSA in patients (i.e., comparison group) relative to image intensity levels derived from healthy controls (HC) (i.e., reference group) based on extreme values. However, the assumptions underlying these approaches have not always been fully validated, and may be dependent on the statistical distributions of the transformed data. The current study evaluated variations of two commonly used techniques (“pothole” method and standardization with an independent reference group) for identifying SSA using simulated data (derived from normal, t and chi‐square distributions) and fractional anisotropy maps derived from 50 HC. Results indicated substantial group‐wise bias in the estimation of extreme data points using the pothole method, with the degree of bias being inversely related to sample size. Statistical theory was utilized to develop a distribution‐corrected z‐score (DisCo‐Z) threshold, with additional simulations demonstrating elimination of the bias and a more consistent estimation of extremes based on expected distributional properties. Data from previously published studies examining SSA in mild traumatic brain injury were then re‐analyzed using the DisCo‐Z method, with results confirming the evidence of group‐wise bias. We conclude that the benefits of identifying SSA in neuropsychiatric research are substantial, but that proposed SSA approaches require careful implementation under the different distributional properties that characterize neuroimaging data. Hum Brain Mapp 35:5457–5470, 2014. © 2014 Wiley Periodicals, Inc.     

情境模拟教学在康复专科护士临床实践教学中的应用探讨

目的分析和探讨康复专科护士学员在临床实践教学中应用情境模拟教学的效果。方法随机将2019年1—12月我院康复医学中心招收的80名康复专科护士学员随机分为观察组和实验组,观察组(40名)采用常规临床带教,实验组(40名)采用情境模拟教学方法。结果实验组学员理论知识平均得分、实践操作平均得分及康复专科护士学员对带教老师满意度均高于观察组(P<0.05)。结论在临床实践教学过程中应用情境模拟教学,能有效提升康复专科护士的理论知识水平及临床实践操作能力,提高教学质量和教学水平,提升教学效果。     

构建医院虚拟学科信息共享中心初探

虚拟学科作为一种创新性的合作模式，是一种临时学科资源优势互相利用的过程。如何实现虚拟学科方便地共享信息．提高合作效率，是虚拟学科要解决的重要问题之一。建立一个信息共享中心，使学科能够对信息共享中心实现友好访问，可解决虚拟学科的信息共享问题，提高虚拟学科的合作效率。     

Vaccinia virus strain LC16m8 defective in the B5R gene keeps strong protection comparable to its parental strain Lister in immunodeficient mice

BackgroundAttenuated vaccinia virus strain, LC16m8, defective in the B5R envelope protein gene, is used as a stockpile smallpox vaccine strain in Japan against bioterrorism: the defect in the B5R gene mainly contributes to its highly attenuated properties.MethodsThe protective activity of LC16m8 vaccine against challenge with a lethal dose of vaccinia Western Reserve strain was assessed in wild-type and immunodeficient mice lacking CD4, MHC class I, MHC class II or MHC class I and II antigens.ResultsThe immunization with LC16m8 induced strong protective activity comparable to that of its parent strain, Lister (Elstree) strain, in wild-type mice from 2 days to 1 year after vaccination, as well as in immunodeficient mice at 2 or 3 weeks after vaccination. These results implicated that the defect in the B5R gene hardly affected the potential activity of LC16m8 to induce innate, cell-mediated and humoral immunity, and that LC16m8 could be effective in immunodeficient patients.ConclusionLC16m8 with truncated B5 protein has an activity to induce immunity, such as innate immunity and subsequent cell-mediated and humoral immunity almost completely comparable to the activity of its parental strain Lister.     

基于PubMed开发的数据分析工具在图书馆工作中的应用

随着信息化的不断发展,图书馆可以使用的科研分析工具将越来越多,图书馆将从过去的以文献检索、全文获取为中心的服务,发展到关注学术研究过程并为其提供针对性、知识化、个性化的深层次服务。     

国外图书馆生物医学科研数据管理服务及启示

通过调研印第安纳大学图书馆和马萨诸塞大学图书馆的科研数据管理的服务模式,对比分析了科研数据管理服务工作的内容、方法、工具等提出了我国图书馆科研数据管理服务模式的设想。     

Comparison of video-recorded laryngeal movements during swallowing by normal young men with piezoelectric sensor and electromyographic signals

The movement of the larynx in five young men during the swallowing of a liquid was examined by simultaneously recording a video-movie, the trajectory of a piezoelectric sensor, and the surface electromyogram of the suprahyoid muscles (SH). The movies revealed swallowing was associated with four characteristic spatial points of laryngeal movement: (1) a slight movement in the superoposterior direction (1.9 ± 1.2 s; mean ± SD of the time elapsed after the command to swallow was issued); (2) the initiation of anterosuperior elevation (2.3 ± 1.3 s); (3) the turn at the highest position (3.2 ± 1.2 s); and (4) the return to the initial position (4.1 ± 1.4 s). The piezoelectric sensor and the SH electromyogram also detected characteristic temporal points that closely corresponded to the characteristic temporal points captured by the video. The advantages of using movies in swallowing research are discussed.     

按三级学科方向培养手术室专科护士可行性的调查

目的：了解不同等级医院对手术室专科护士的需求,探索能满足不同等级医院手术室护理工作实际需求的专科护士培训方案。方法自行设计调查表,选择在江苏省手术室专科护士培训基地学习的80名手术室护士进行调查。调查内容包括一般资料、所在医院三级学科和亚专业学科细化情况、参加专科护士培训后工作状况、手术室专科护士的培养模式和按照三级学科培养手术室专科护士的实施方案4个方面。结果80名护士均认为有必要开展手术室专科护士培训,80．00％的人认为目前模式属手术室全科护士的培训;72．22％的二级医院的护士认为参加培训学习的理论知识、参加的临床实践技能能满足工作需要,可继续采取目前培养模式;74．19％的三级医院的护士认为培训知识尚能满足工作需要,但针对自己的三级学科方向还不够强、不够细,应该按照三级学科培养手术室专科护士。结论根据不同等级医院手术室护理工作的实际需求,建立统一招生、同步培训、分层培养的统分结合培养模式,能培养适应不同等级医院手术室需求的专科护士。