全文获取类型
收费全文 | 5402篇 |
免费 | 244篇 |
国内免费 | 92篇 |
专业分类
耳鼻咽喉 | 133篇 |
儿科学 | 96篇 |
妇产科学 | 36篇 |
基础医学 | 629篇 |
口腔科学 | 144篇 |
临床医学 | 627篇 |
内科学 | 868篇 |
皮肤病学 | 63篇 |
神经病学 | 550篇 |
特种医学 | 120篇 |
外科学 | 741篇 |
综合类 | 503篇 |
预防医学 | 693篇 |
眼科学 | 64篇 |
药学 | 241篇 |
2篇 | |
中国医学 | 25篇 |
肿瘤学 | 203篇 |
出版年
2023年 | 85篇 |
2022年 | 160篇 |
2021年 | 223篇 |
2020年 | 204篇 |
2019年 | 210篇 |
2018年 | 231篇 |
2017年 | 214篇 |
2016年 | 226篇 |
2015年 | 219篇 |
2014年 | 421篇 |
2013年 | 427篇 |
2012年 | 296篇 |
2011年 | 365篇 |
2010年 | 272篇 |
2009年 | 230篇 |
2008年 | 288篇 |
2007年 | 218篇 |
2006年 | 194篇 |
2005年 | 162篇 |
2004年 | 96篇 |
2003年 | 110篇 |
2002年 | 86篇 |
2001年 | 55篇 |
2000年 | 70篇 |
1999年 | 57篇 |
1998年 | 50篇 |
1997年 | 39篇 |
1996年 | 31篇 |
1995年 | 36篇 |
1994年 | 43篇 |
1993年 | 39篇 |
1992年 | 30篇 |
1991年 | 43篇 |
1990年 | 31篇 |
1989年 | 31篇 |
1988年 | 29篇 |
1987年 | 25篇 |
1986年 | 19篇 |
1985年 | 30篇 |
1984年 | 33篇 |
1983年 | 16篇 |
1982年 | 14篇 |
1981年 | 11篇 |
1980年 | 9篇 |
1979年 | 10篇 |
1978年 | 8篇 |
1977年 | 14篇 |
1976年 | 8篇 |
1975年 | 5篇 |
1974年 | 6篇 |
排序方式: 共有5738条查询结果,搜索用时 31 毫秒
91.
92.
93.
94.
Gabriel Alcalá-Cerra Ángel Paternina-Caicedo Cindy Díaz-Becerra Juan José Gutiérrez-Paternina 《Neurocirugía (Asturias, Spain)》2013,24(4):154-162
ObjectiveThe objective of our study was to determine the seizure control rate of cerebral hemispherectomies in adult patients with drug-resistant epilepsy.Materials and methodsA systematic review and individual patient data meta-analysis was carried out. Seven international databases and scientific meeting proceedings were reviewed. Individual patient data were analysed to establish potential factors associated with postoperative seizure control.ResultsEight articles that satisfied the pre-established selection criteria were identified.After a median follow-up of 70 months (interquartile range, 29-175.5), 79.4% of patients remained seizure-free. There were no statistically significant differences in age at onset of epilepsy, duration of epilepsy, age at surgery, time of follow-up, gender, surgical-laterality, aetiology and ictal EEG abnormalities between seizure-free patients and those with recurrences.ConclusionsCerebral hemispherectomy has a high seizure control rate in adult patients with drug-resistant epilepsy. None of the variables analysed in the present study were associated with surgical success. 相似文献
95.
Ulrich Jarry Pascale Jeannin Laurent Pineau Sabrina Donnou Yves Delneste Dominique Couez 《European journal of immunology》2013,43(5):1173-1184
Microglia are the major myeloid‐immune cells of the brain parenchyma. In a steady state, microglia monitor their environment for pathogens or damaged cells. In response to neural injury or inflammation, microglia become competent APCs able to prime CD4+ and CD8+ T lymphocytes. We previously demonstrated that neonatal and adult microglia cross‐present exogenous soluble Ags in vitro. However, whether microglia are able to cross‐present Ag to naive CD8+ T cells in vivo, within the brain microenvironment, remains undetermined. Here, we have designed an original protocol in order to exclude the involvement in cross‐presentation activity of peripheral migrating APCs and of CNS‐associated APCs. In C57Bl/6 mice, in which the body but not the head has been properly irradiated, we analyzed the ability of resident microglia to stimulate intracerebrally injected CD8+ T cells in vivo. This study demonstrates for the first time that adult microglia cross‐present Ag to naive CD8+ T cells in vivo and that full microglia activation is required to overcome the inhibitory constrains of the brain and to render microglia able to cross‐prime naive CD8+ T cells injected in the brain. These observations offer new insights in brain‐tumor immunotherapy based on the induction of cytotoxic antitumoral T cells. 相似文献
96.
《Brain stimulation》2021,14(5):1059-1067
BackgroundThere is still a lack of controlled studies to prove efficacy of thalamic deep brain stimulation for Tourette's Syndrome.ObjectivesIn this controlled trial, we investigated the course of tic severity, comorbidities and quality of life during thalamic stimulation and whether changes in tic severity can be assigned to ongoing compared to sham stimulation.MethodsWe included eight adult patients with medically refractory Tourette's syndrome. Bilateral electrodes were implanted in the centromedian-parafascicular-complex and the nucleus ventro-oralis internus. Tic severity, quality of life and comorbidities were assessed before surgery as well as six and twelve months after. Short randomized, double-blinded sham-controlled crossover sequences with either active or sham stimulation were implemented at both six- and twelve-months’ assessments. The primary outcome measurement was the difference in the Yale Global Tic Severity Scale tic score between active and sham stimulation. Adverse events were systematically surveyed for all patients to evaluate safety.ResultsActive stimulation resulted in significantly higher tic reductions than sham stimulation (F = 79.5; p = 0.001). Overall quality of life and comorbidities improved significantly in the open-label-phase. Over the course of the trial two severe adverse events occurred that were resolved without sequelae.ConclusionOur results provide evidence that thalamic stimulation is effective in improving tic severity and overall quality of life. Crucially, the reduction of tic severity was primarily driven by active stimulation. Further research may focus on improving stimulation protocols and refining patient selection to improve efficacy and safety of deep brain stimulation for Tourette's Syndrome. 相似文献
97.
Francesc Feliu Juan C. Rueda Jorge Escuder Fernando Gris Andrea Jiménez Vicente Vicente 《International surgery》2013,98(4):392-398
Intussusception is a rare cause of adult intestinal obstruction. Clinical manifestations are not specific, which makes a preoperative diagnosis difficult to establish and often causes delay. We report a case of acute intestinal obstruction due to ileocolic intussusception. An emergency laparoscopy was performed revealing an obstructive mass at the ileocecal region resulting from an appendicular tumor. A right hemicolectomy was conducted. The pathologic examination of the resected sample concluded the mass comprised an appendicular mucinous cystoadenoma. We discuss the clinical features, preoperative diagnosis, and surgical strategies of adult intussusception, as well as the uncommon finding of an appendicular mucinous tumor as its causative lesion, with a review of the available literature. 相似文献
98.
99.
Muge Gulen Yeliz Simsek Emre Oner Salim Satar 《The American journal of emergency medicine》2018,36(6):1126.e5-1126.e6
Alpha lipoic acid (ALA), which is an anti-oxidant acting as a scavenger for reactive oxygen species, is especially used to improve glycemic control and prevent polyneuropathies associated with diabetes mellitus. ALA is considered to be a safe drug and intoxication with ALA is extremely rare. However, this paper reports a 38-year-old young woman who was admitted to the emergency department after she had ingested ten pills of 600 mg ALA belonging to her diabetic parent, which led to delirium, metabolic acidosis, thrombocytopenia, and rhabdomyolysis. To the best of our knowledge, there are only four cases of ALA intoxication reported in the literature and all were observed in children. This report aims to present the first case of ALA related intoxication worldwide in an adult patient. 相似文献
100.