长春西汀治疗血管性痴呆认知功能障碍的疗效观察

目的：探讨长春西汀对血管性痴呆（VD）患者认知功能障碍的治疗作用。方法：VD患者42例随机分为长春西汀组和对照组各21例,分别给予长春西汀和胞二磷胆碱治疗,治疗前后分别测定2组患者的瑞文测验联合型（CRT）及临床记忆量表（CMS）评分。结果：长春西汀组治疗前后有显著性差异,而对照组无明显好转。结论：长春西汀对改善VD患者的认知障碍具有显著疗效。     

通神复脑丸联合长春西汀佐治后循环缺血性眩晕临床研究

目的 探讨通神复脑丸联合长春西汀佐治后循环缺血性眩晕的临床疗效.方法 选取医院2019年8月至2020年5月收治的后循环缺血性眩晕患者102例,随机分为观察组和对照组,各51例.两组患者均予长春西汀注射液静脉滴注,观察组患者加服通神复脑丸,两组均连续治疗12周.结果 观察组未严格执行治疗方案1例、中途退出1例,对照组失...     

From the Cover: Vinpocetine inhibits NF-κB–dependent inflammation via an IKK-dependent but PDE-independent mechanism

Inflammation is a hallmark of many diseases, such as atherosclerosis, chronic obstructive pulmonary disease, arthritis, infectious diseases, and cancer. Although steroids and cyclooxygenase inhibitors are effective antiinflammatory therapeutical agents, they may cause serious side effects. Therefore, developing unique antiinflammatory agents without significant adverse effects is urgently needed. Vinpocetine, a derivative of the alkaloid vincamine, has long been used for cerebrovascular disorders and cognitive impairment. Its role in inhibiting inflammation, however, remains unexplored. Here, we show that vinpocetine acts as an antiinflammatory agent in vitro and in vivo. In particular, vinpocetine inhibits TNF-α–induced NF-κB activation and the subsequent induction of proinflammatory mediators in multiple cell types, including vascular smooth muscle cells, endothelial cells, macrophages, and epithelial cells. We also show that vinpocetine inhibits monocyte adhesion and chemotaxis, which are critical processes during inflammation. Moreover, vinpocetine potently inhibits TNF-α- or LPS-induced up-regulation of proinflammatory mediators, including TNF-α, IL-1β, and macrophage inflammatory protein-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in a mouse model of TNF-α- or LPS-induced lung inflammation. Interestingly, vinpocetine inhibits NF-κB–dependent inflammatory responses by directly targeting IKK, independent of its well-known inhibitory effects on phosphodiesterase and Ca²⁺ regulation. These studies thus identify vinpocetine as a unique antiinflammatory agent that may be repositioned for the treatment of many inflammatory diseases.     

长春西汀及其类似物的合成和构效关系研究进展

总结介绍了20世纪90年代以来长春西汀及其类似物的合成及构效关系研究成果。长春西汀是生物碱长春胺的合成衍生物,是目前临床治疗和预防缺血性脑血管疾病的一线药物,近年来研究人员展开了对其衍生物合成路线及生物活性的相关研究,以期进一步阐明该类化合物作用机制和发现活性更好的衍生物。     

长春西汀与舒血宁对脑缺血性疾病的血流动力学影响

目的 评价长春西汀与活血药物舒血宁对急性脑梗死（ACI）及慢性脑缺血（CCI）的脑血流动力学影响.方法 ACI及CCI患者各60例,随机分为长春西汀A、B组及舒血宁A、B组.分别于治疗前及治疗后30 d给予脑血流动力学指标（CVHI）检测.结果 在ACI患者中,2组患者治疗30 d后CVHI各参数均显著改善,其中长春西汀A组最小瞬时血流量（Qd）指标改善显著优于舒血宁A组（P＜0 05）.在CCI患者中,2组患者治疗30 d后CVHI各参数均显著改善,其中长春西汀B组外周阻力（Rv）、临界压（CP）指标改善显著优于舒血宁B组（P＜0.05或P＜0.01）.结论 长春西汀更适用于改善CCI所致的症状性头晕.     

长春西汀药理作用机制研究进展

长春胺是从小蔓长春花中分离得到的一种生物碱,长春胺衍生物长春西汀在中风后遗症、老年痴呆、神经性耳鸣及耳聋、美尼尔氏综合症、缺血性眼底疾病等复杂性疾病方面有一定的疗效。从近年来长春西汀药理作用研究进展着手,进一步探讨其发挥临床疗效的机制。     

长春西汀葡萄糖注射液细菌内毒素检查的实验研究

目的：建立用鲎试剂检查长春西汀葡萄糖注射液细菌内毒素的方法。方法：对用家兔法热原检查合格的长春西汀葡萄糖注射液作细菌内毒素检查的干扰试验。结果：长春西汀葡萄糖注射液对鲎试剂的细菌内毒素检查无干扰。结论：凝胶法鲎试验可用于长春西汀葡萄糖注射液的细菌内毒素检查。     

长春西汀注射液治疗急性脑梗塞的临床观察

目的观察长春西汀对急性脑梗塞的治疗和保护作用。方法选取符合诊断标准的急性脑梗塞患者81例，随机分为：治疗组42例，对照组39例。治疗组给予常规治疗＋长春西汀注射液30mg静脉点滴，对照组不用长春西汀，只给予常现治疗7～10日为一疗程。结果长春西汀注射液治疗急性脑梗塞，不同程度意识障碍患者的转醒时间与对照组比较具有显着差异（P〈0．01）其疗效于对照组比较具有显着差异（P〈0．05）。结论长春西汀对急性脑梗塞具有治疗和保护作用。     

长春西汀在家兔体内药代动力学的研究

本实验用高效液相色谱法（ＨＰＬＣ）测定了长春西汀在家兔体内的药代动力学参数。家兔静脉注射本品１０ｍｇ／ｋｇ体重，时量曲线属二室开放模型，ｔ１／２β为１．８１±０．２６ｈｒ；Ｖｄ为４．６３±０．１３Ｌ／ｋｇ；ＣＬ为３０±５ｍｌ／ｍｉｎ·ｋｇ－１。本品灌胃（ｉｇ）给药，吸收不良，生物利用度为１０±７％。     

Cyclic GTP imitates the potentiating effect of the nootrope vinpocetine on the high-threshold A-current in mollusk neurons

Isolated common snail neurons were studied using two-microelectrode potential clamping to record high-threshold (threshold=10 mV) rapidly-inactivating potassium current (I _Aht); the effects of the nootrope vinpocetine on this current were studied and were compared with the effects of cyclic nucleotides. Intracellular application of dibutyryl derivatives of cyclic adenosine monophosphate (dcAMP) and guanosine monophosphate (dcGMP) was used. The results showed that vinpocetine potentiates or fails to alterI _Aht in different cells, while dcGMP imitates the effect of vinpocetine. Simultaneous application of vinpocetine and dcGMP did not result in additive effects. Unlike dcGMP, dcAMP did not imitate the effects of vinpocetine, and decreasedI _Aht in most cells. These data suggest that cGMP mediates the potentiating effect of vinpocetine onI _Aht. Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 84, No. 8, pp. 741–746, August, 1998