静脉滴注阿昔洛韦联合黄芪注射液治疗扁平疣疗效观察

目的:评估静脉滴注阿昔洛韦联合黄芪注射液治疗扁平疣临床疗效。方法:将72例扁平疣患者随机分为静脉滴注阿昔洛韦联合黄芪注射液组(治疗组)和静脉滴注阿昔洛韦组(对照组),每组36例,疗程2周,比较两组疗效。结果:治疗组总有效率为94.4%,未见不良反应;对照组总有效率为80.6%,治疗组疗效优于对照组(P<0.05)。结论:静脉滴注阿昔洛韦和黄芪注射液治疗扁平疣疗效好,安全,值得在临床中试用。     

优美诺皮肤消毒剂联合干扰素α-2b治疗多发性跖疣临床观察

目的探讨优美诺皮肤消毒剂联合干扰素α-2b治疗多发性跖疣的临床疗效。方法选取医院2017年9月至2018年12月收治的多发性跖疣患者140例,随机分为试验组和对照组,各70例。两组均予干扰素α-2b注射液治疗,试验组患者加用优美诺皮肤消毒剂。结果试验组总有效率为95.71%,显著高于对照组的81.43%(P<0.05);试验组复发率为11.43%,显著低于对照组的22.86%(P<0.05);两组均未见严重不良反应。结论优美诺皮肤消毒剂联合干扰素α-2b治疗多发性跖疣有一定疗效,且复发率较低。     

中西医结合治疗扁平疣的疗效观察

目的：探讨扁平疣的中西医结合治疗。方法：将138例扁平疣患者，分别进行中医辨证分型，肝胆湿热型62例，瘀血阻滞型46例，阴虚火旺型30例。采用随机方法将3型患者分别平均分成治疗组和对照组。每组中肝胆湿热型31例，瘀血阻滞型23例，阴虚火旺型15例。治疗组给予中医辨证分型，中药内服及外搽联合重组干扰素α-2b肌注，对照组用聚肌胞外搽联合重组干扰素α－2b肌注。观察两组的疗效。结果：治疗组总有效率为94．20％，对照组总有效率为72．46％，治疗组疗效明显高于对照组（P＜0．05）。结论：中西医结合治疗扁平疣疗效确切。     

PCR快速准确的诊断女阴尖锐湿疣

女阴尖锐湿疣和湿疣样病变共400例,用HPV—PCR进行检测。结果:306例HPV—DNA阳性诊断为女阴尖锐湿疣,占76.5%。94例HPV—DNA阴性诊断为湿疣样病交,占23.5%。应用HPV—DNA—PCR技术对尖锐湿疣和湿疣样病变进行鉴别诊断和诊断,具有快速准确的特点。另外,本文还对尖锐湿疣和非湿疣性外阴赘生物(湿疣样病变)的肉眼形态特点作了描述。     

乙双吗啉治疗扁平疣50例

作者选择了对抗多种药物、皮损范围广泛的50例扁平疣患者,应用乙双吗啉治疗,治愈率为38％,总有效率达68％,本组与维生素B_(12)组50例对照有非常显著差异,故认为乙双吗啉为治疗难治、泛发扁平疣的有效药物.     

CO_2激光照射外用MEBO治疗面部扁平疣

目的:探讨CO_2激光治疗面部扁平疣后的创面外涂MEBO的疗效。方法:对185例面部扁平疣患者先运用CO_2激光汽化治疗扁平疣病灶,烧灼后创面外涂MEBO,对创面的修复及扁平疣的复发率进行观察。结果:185例患者经二年随访,一次治愈169例(91.35%),二次治愈16例(8.65%),色素沉着15例(8.11%),总有效率100%。无一例患者创面发生感染,色素沉着者3个月～6个月后自行消退。结论:MEBO对CO_2烧灼后创面有显著治疗作用,且使用方便,无副作用。     

In situ detection of HPV DNA in oral mucosal lesions. A comparison of two hybridization kits

The purpose of this study was to compare the sensitivity of ViraType in situ hybridization kit (Life Technologies, Inc. [LT] and PathoGene (Enzo Diagnostics, Inc. [ED]) in situ hybridization kit for human papillomavirus (HPV) DNA detection in oral tissue. Forty benign oral lesions histologically suspicious for HPV infection were analyzed. Specimens were hybridized with DNA probes specific for HPV types 6/11, 16/18, and 31/33/35 [LT] and HPV types 6/11, 16/18, and 31/33/51 [ED]. Positive hybridization reactions were seen for HPV DNA type 6/11 only. Hybridization occurred significantly more often (p less than 0.01, McNemar Exact Test) in LT probed specimens (20/40) than ED assayed sections (12/40). HPV DNA sequences were found in 100% condyloma acuminata (13/13), 100% verruca vulgaris (4/4), and 13% squamous papilloma (3/23) using the LT system. The ED probes yielded positive signals in 77% condyloma acuminata (10/13), 25% verruca vulgaris (1/4), and 4.4% squamous papilloma (1/23). A more intense hybridization signal was exhibited using the LT system. The results indicate that the LT probes and detection reagents are more sensitive for detecting HPV DNA in oral mucosal specimens.     

注射式皮下植入法自体疣移植治疗扁平疣临床观察

目的：探讨运用注射式皮下植入法自体疣移植治疗扁平疣的临床疗效和不良反应。方法：将98例扁平疣患者随机分成两组,试验组50例,采取自体疣注射式皮下植入法治疗;对照组48例,采用传统自体疣植入法治疗,治疗前后均进行数码相机拍照,治疗结束3个月后观察皮损消退面积大小,使用Adobe Photoshop网格分析法计算单位面积。结果：试验组有效率为92.0%,对照组为85.4%,两组有效率差异无统计学意义（χ2=1.065,P〉0.05）。两组患者中,有90例在痊愈前数天出现皮损突然增多、增大现象,伴有发红、瘙痒等症状,一般无需处理。结论：注射式皮下植入法治疗扁平疣操作简便,疗效明显,值得临床推广应用。