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91.
Intubating conditions after vecuronium and atracurium given in divided doses (the priming technique)
R. K. Mirakhur G. G. La Very F. M. Gibson R. S. J. Clarke 《Acta anaesthesiologica Scandinavica》1986,30(5):347-350
Intubating conditions have been assessed at 60 s following administration of vecuronium 0.1 mg kg-1 or atracurium 0.5 mg kg-1 given either as a single dose after induction of anaesthesia with thiopentone or in divided doses; vecuronium 0.015 mg kg-1 followed 4 or 6 min later by 0.085 mg kg-1, or atracurium 0.075 mg kg-1 followed 4 or 6 min later by 0.425 mg kg-1. In the divided dose groups the smaller initial (priming) dose was given prior to induction of anaesthesia. Onset and duration of clinical relaxation were assessed using a peripheral nerve stimulator. The intubating conditions at 60 s improved significantly, with the use of relaxants in divided doses being acceptable in 80 and 70% of patients, respectively, with vecuronium and atracurium, but the conditions are not as good as those commonly found using suxamethonium. Priming at 6 min has no advantage over priming at 4 min. The onset of complete block was accelerated with priming, but the difference was not significant. The duration of clinical relaxation of vecuronium was significantly prolonged by giving it in divided doses. Unpleasant awareness of muscle weakness was observed in 15 patients, requiring early induction of anaesthesia in five of them. 相似文献
92.
目的 探讨Ⅴ型斜视伴原发性下斜肌功能过强的治疗效果。方法根据手术方式将49例Ⅴ型斜视伴下斜肌功能过强惠者分为四组,分别采用水平肌加强减弱术不联合下斜肌切断减弱术(Ⅰ组)、联合单侧下斜肌切断减弱术(Ⅱ组)、联合双侧下斜肌对等切断减弱术(Ⅲ组)及联合双侧下斜肌不对等切断并部分切除减弱术(Ⅳ组)治疗Ⅴ型斜视。结果Ⅴ型斜视伴原发性下斜肌功能过强采用四种方式治疗后,眼位正位,下斜肌功能亢进改善+~++,双侧下斜肌功能对等,术前术后原在位度数和上下注视25。斜视角之差的差异有非常显著性(P〈0.001)。结论根据单侧或双侧下斜肌功能过强的具体情况来选择不同的手术方式治疗Ⅴ型斜视伴原发性下斜肌功能过强,眼位矫正满意,同时手术方式简单、安全有效。 相似文献
93.
雷帕霉素靶蛋白反义RNA真核表达载体的构建及其在血管平滑肌细胞中的表达 总被引:5,自引:2,他引:3
目的构建雷帕霉素靶蛋白(mTOR)的反义RNA真核表达载体,观察其对血管平滑肌细胞(VSMC)功能的影响。方法提取人VSMC总RNA,逆转录.聚合酶链反应(RT-PCR)扩增mTOR基因cDNA序列,经pGEM-T载体克隆后双酶切,将cDNA序列反向插入绿色荧光蛋白表达载体pEGP-C1,转染VSMC,Westernblot法检测反义表达载体对mTOR蛋白表达的影响,流式细胞仪检测细胞周期的变化。结果经RT-PCR获得664bp产物,T载体克隆后,酶切确定该片段为mTOR基因cDNA,进而构建反义RNA真核表达载体pEGFP-C1-mTOR,测序证明序列正确后转染VSMC,证实其能够显著抑制mTOR蛋白产物表达,转染72h的mTOR蛋白产物表达抑制率达82%,S期细胞由15%降低为7%,凋亡细胞增至9%。VSMC增殖过程在Gx/Go期→S期受阻。结论成功构建mTOR基因的反义RNA真核表达载体。 相似文献
94.
目的评价以髂深血管为蒂的髂骨—腹内斜肌双岛状瓣(简称同蒂双岛状瓣)修复下颌复合组织缺损的临床应用价值。方法2005年1月至2006年10月,应用同蒂双岛状瓣修复10例下颌骨复合组织缺损(包括下颌骨体部、下颌角和下颌骨升支及其周围软组织,其中有7例还包含髁突的缺损)。结果10例同蒂双岛状瓣移植均获成功,仅1例出现局部轻度感染,换药后二期愈合。术后随访3~24个月,均无肿瘤复发,颌面外形两侧基本对称,咬合关系恢复正常,且供区未见明显的并发症。结论同蒂双岛状瓣具有切口隐蔽、单一,对供区功能影响小,软硬组织复合缺损同期修复效果好等特点,是半侧下颌骨复合周围软组织大型缺损功能重建的较好方案。 相似文献
95.
96.
Henk M M L De Feyter Gert Schaart Matthijs K Hesselink Patrick Schrauwen Klaas Nicolay Jeanine J Prompers 《Magnetic resonance in medicine》2006,56(1):19-25
1H MR spectroscopy (MRS) has proved to be a valuable noninvasive tool to measure intramyocellular lipids (IMCL) in research focused on insulin resistance and type II diabetes in both humans and rodents. An important determinant of IMCL is the muscle fiber type, since oxidative type I fibers can contain up to three times more IMCL than glycolytic type II muscle fibers. Because these different muscle fiber types are inhomogeneously distributed in rodent muscle, in the present study we investigated the distribution of IMCL within the rat tibialis anterior muscle (TA) in vivo using single-voxel 1H MRS along with the muscle fiber distribution in the TA ex vivo determined from immunohistological assays. IMCL levels in the TA differed by up to a factor of 3 depending on the position of the voxel. The distribution of IMCL over the TA cross section was not random, but emerged in a pattern similar to the distribution of the predominantly oxidative muscle fiber types. Dietary interventions, such as high-fat feeding and 15 hr of fasting, did not significantly change this typical fiber type-dependent pattern of IMCL content. These results stress the importance of voxel positioning when single-voxel 1H MRS is used to study IMCL in rodent muscle. 相似文献
97.
1 The internal anal sphincter (IAS) has a spontaneous tone and is the main contributor to the maintenance of faecal continence. The spontaneous resting tone exhibited by the sphincter can be modified by neurotransmitters from the autonomic and enteric nervous systems. 2 In this review, the influence of the sympathetic and parasympathetic nervous systems on IAS tone are discussed and the putative roles of nitric oxide, carbon monoxide, vasoactive intestinal peptide and adenosine triphosphate in non‐adrenergic non‐cholinergic transmission are considered. 3 Faecal incontinence is a common condition that places a heavy financial burden on the health service and severely affects patients’ quality of life. Resting anal pressure is reduced in patients with faecal incontinence and agents that increase sphincter tone tend to relieve symptoms. The results of clinical studies of the use of phenylephrine to treat faecal incontinence are reviewed. 4 It is concluded that the IAS is a potential target for drug development for the treatment of faecal incontinence. 相似文献
98.
Charlotte J. Harden Bernard M. Corfe J. Craig Richardson Peter W. Dettmar Jenny R. Paxman 《Nutrition Research》2009
This cross-sectional analysis evaluated the effect of age and body mass index (BMI) on Three-Factor Eating Questionnaire scores in males. Subjects (n = 60) were recruited according to BMI status. Each completed the 51-item Three-Factor Eating Questionnaire. The group was split at the median age to produce a “younger” and “older” group for statistical analysis. A 2-way between-groups analysis of variance revealed a significant main effect of BMI on disinhibition (P = .003) and hunger (P = .041) with higher levels found in overweight males compared to healthy-weight counterparts. A significant main effect of age on hunger (P = .046) demonstrated older males were less susceptible to hunger than younger males. These insights provide a better understanding of eating behavior across the male life cycle and may assist health professionals to better guide men in weight management in the light of rising overweight/obesity. 相似文献
99.
<正>1906年,Crile等人针对头颈部恶性肿瘤易发生颈淋巴结转移的情况提出了根治性颈淋巴清扫术(radical neck dissection,RND),这一术式在后来的很多年里,挽救了许多患者的生命。但RND损伤了副神经和颈部的一些重要的解剖结构,常导致患者斜方肌瘫痪萎缩,出现翼状肩胛、垂肩、肩周疼痛麻木、手臂活动受限、功能障碍等并发症, 相似文献
100.
目的 评价子宫动脉栓塞术治疗子宫肌瘤的近期疗效。方法 89例子宫肌瘤患者,采用Seldinger技术分别作左右子宫动脉主干插管检查和栓塞治疗,栓塞剂采用聚乙稀醇颗粒(PVA)或白芨混合颗粒。结果 72例(80.9%)完成随访,随访时间1~28个月。有94.1%(64/68)的患者月经复常;治疗后瘤体缩小25.2%~76.8%(M=41.3%)。除了术中术后疼痛(65例)和发热(16例)外,有2例因肌瘤坏死行子宫切除术,1例出现卵巢早衰。结论 子宫动脉栓塞术治疗子宫肌瘤的近期疗效满意,远期疗效尚待进一步观察。 相似文献