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971.
Molly Szerlip Konstantinos S. Spargias Raj Makkar Saibal Kar Robert M. Kipperman William W. O’Neill Martin K.C. Ng Robert L. Smith Neil P. Fam Michael J. Rinaldi O. Christopher Raffel Darren L. Walters Justin Levisay Matteo Montorfano Azeem Latib John D. Carroll Georg Nickenig Stephan Windecker D. Scott Lim 《JACC: Cardiovascular Interventions》2021,14(14):1538-1548
ObjectivesThis study reports 2-year outcomes from the multicenter, prospective, single-arm CLASP study with functional mitral regurgitation (FMR) and degenerative MR (DMR) analysis.BackgroundTranscatheter repair is a favorable option to treat MR. Long-term prognostic impact of the PASCAL transcatheter valve repair system in patients with clinically significant MR remains to be established.MethodsPatients had clinically significant MR ≥3+ as evaluated by the echocardiographic core laboratory and were deemed candidates for transcatheter repair by the heart team. Assessments were performed by clinical events committee to 1 year (site-reported thereafter) and core laboratory to 2 years.ResultsA total of 124 patients (69% FMR, 31% DMR) were enrolled with a mean age of 75 years, 56% were male, 60% were New York Heart Association functional class III to IVa, and 100% had MR ≥3+. At 2 years, Kaplan-Meier estimates showed 80% survival (72% FMR, 94% DMR) and 84% freedom from heart failure (HF) hospitalization (78% FMR, 97% DMR), with 85% reduction in annualized HF hospitalization rate (81% FMR, 98% DMR). MR ≤1+ was achieved in 78% of patients (84% FMR, 71% DMR) and MR ≤2+ was achieved in 97% (95% FMR, 100% DMR) (all p < 0.001). Left ventricular end-diastolic volume decreased by 33 ml (p < 0.001); 93% of patients were in New York Heart Association functional class I to II (p < 0.001).ConclusionsThe PASCAL repair system demonstrated sustained favorable outcomes at 2 years in FMR and DMR patients. Results showed high survival and freedom from HF rehospitalization rates with a significantly reduced annualized HF hospitalization rate. Durable MR reduction was achieved with evidence of left ventricular reverse remodeling and significant improvement in functional status. The CLASP IID/IIF randomized pivotal trial is ongoing. 相似文献
972.
目的 回顾性评价单侧椎弓根螺钉固定经椎间孔椎体间融合(transforaminal lumbar interbody fusion,TLIF)术或合并对侧经椎板关节突螺钉(translaminar facet screw,TLFS)治疗老年患者退行性腰椎滑脱中期随访的临床效果.方法 2009年1月至2012年6月,收集65岁及以上罹患腰椎退行性滑脱伴腰椎管狭窄的患者29例,男性11例,女性18例;年龄65~ 81岁,平均(73.1±6.1)岁;其中单节段患者16例,双节段患者13例;平均随访时间为39.4±9.8个月(24 ~ 54月).单节段患者采用旁正中入路行单侧椎弓根螺钉固定TLIF术,双节段患者在进行单侧双节段椎弓根置钉固定TLIF术后合并对侧TLFS术.记录手术时间、出血量、住院时间及相关并发症;评价手术前后ODI、VAS及JOA评分;使用X线摄片及三维CT评价节段融合情况及矢状位队列情况.结果 平均手术时间为99.5±32.3 min(单节段86.3±25.5 min,双节段115.8±32.4 min),平均住院为12.9±3.7d(单节段12.8 ±2.0d,双节段13.1±5.1d),平均出血量为210.3±181.0 mL(单节段195.0±192.0 mL,双节段229.2±164.5 mL),并发症发生率为10.3%,24个月时滑脱节段融合率为89.7%.术后ODI、VAS及JOA评分改变较术前有统计学差异,术后腰椎前凸角及滑脱节段前凸角较术前增加(32.0±13.8)°vs (36.5±11.6)°;(4.9±5.5)°vs(6.5±4.4)°,差异有统计学意义;但相关前凸角及其改变与临床各评分及其改变无明确相关性.结论 单侧椎弓根螺钉固定TLIF术治疗老年单节段腰椎退行性滑脱安全有效,并发症低;在此基础上合并使用对侧TLFS术治疗老年双节段腰椎退行性滑脱患者,效果同样良好. 相似文献
973.
《JACC: Cardiovascular Interventions》2015,8(6):850-857
ObjectivesThe aim of this paper is to describe the feasibility of a novel transcatheter approach for mitral valve replacement using only venous access.BackgroundFailure of mitral valve prostheses necessitating reoperation can represent a high-risk clinical scenario. Although repeat cardiac surgery remains the standard of care for most failed mitral valve operations, nascent transcatheter options are under development for patients at high or extremely risk of surgery. Most often, this is performed via a transapical approach in the operating room, with associated risk of complications as well as extended length of hospital stay.MethodsWe describe a case series of 4 consecutive patients at high risk of reoperation with degenerative mitral prostheses (bioprosthetic valves or rings) who successfully underwent transvenous, transseptal mitral valve replacement with a commercially available transcatheter heart valve.ResultsFrom April to May 2014, 4 consecutive patients underwent transvenous, transseptal mitral valve replacement with a transcatheter heart valve. The mean age was 72 ± 9.9 years, and the average Society of Thoracic Surgeons risk score was 12.5 ± 7.2%. All patients had severe, life-limiting dyspnea. The 4 procedures were successful without intra- or post-procedural complications; echocardiography indicated a well-seated and functioning mitral valve-in-valve or valve-in-ring. Patients were discharged within 2 days after valve replacement with marked improvement in dyspnea.ConclusionsWe describe an innovative technique of transcatheter mitral valve replacement. This case series demonstrates the feasibility of transcatheter mitral valve replacement using only femoral venous access, with a marked reduction in complications and length of hospital stay compared with transapical access or redo surgery. 相似文献
974.
975.
Background
Patellar tendon rupture is rare in the general population. Typically, failure occurs proximally or at the mid-substance. Distal avulsion from the tibial tubercle in adults is rare and not well described in the orthopedic literature.Methods
We present the largest series of patients with distal patellar tendon injury with associated multi-ligamentous disruption of the knee. A series of six patients with distal patellar tendon avulsion were identified at a single institution. The cases were reviewed and are presented.Results
Each case of distal patellar tendon rupture was associated with high-energy trauma to the knee. There was multi-ligamentous disruption in all cases, associated tibial plateau fracture in one case, and a compartment syndrome diagnosed in another. We propose that distal patellar tendon avulsion is a distinct pathology of the extensor mechanism in healthy adults. When present, it should prompt clinicians to assess patients for occult knee dislocation, monitor their neurovascular status, and obtain an MRI to evaluate for associated multi-ligamentous injury.Conclusion
We propose a modification to the Schenk classification to include extensor mechanism injury to help guide steps of operative intervention. 相似文献976.
Diffusion‐Weighted Magnetic Resonance Imaging and Apparent Diffusion Coefficient Mapping for Diagnosing Infectious Spondylodiscitis: A Preliminary Study 下载免费PDF全文
977.
Background:
Total meniscus resection after meniscus tear usually leads to faster degeneration and osteoarthritis of the knee joint. Preservation and repair of the injured menisci are therefore of great clinical importance. The aim of this study was to evaluate the clinical effects of arthroscopic repair of meniscal injuries using the Fast-Fix device.Materials and Methods:
96 patients (58 males, 38 females) with mean age of 24.3 years (range 12–46 years)) with a meniscus injury were treated with the Fast-Fix device under arthroscopy between July 2007 and June 2009. The right and left knees were involved in 46 and 50 patients respectively. In 12, 46 and 38 patients, the injury was located in the anterior horn, body and posterior horn respectively. In 38, 45 and 13 patients, it was in the red, red-white, and white regions, respectively. All-inside and outside-in techniques were used for these meniscal injuries. Criteria for successful surgery were no locking pain or swelling and a negative McMurray test.Results:
The mean followup period was 3.7 years (range 2–5 years). The surgical success rate was 91.7% (n = 88). The mean Lysholm score increased from 47.8 ± 10.4 preoperatively to 85.7 ± 12.8 postoperatively. The mean Tegner activity score was 7.4 ± 1.6 (range 5–9) preinjury, 2.1 ± 0.9 (range 0–4) preoperatively and 7.2 ± 2.2 (range 4–10) postoperatively (P < 0.001). A total of 92 patients (95.8%) returned to full-time work. The International Knee Documentation Committee score increased from 32.7 ± 10.7 (range 10.3–51.7) preoperatively to 82.5 ± 5.1 (range 65.1–91.2) postoperatively (P < 0.001).Conclusions:
The Fast-Fix system is an efficient, safe and effective suture technique for meniscal repair. 相似文献978.
Spontaneous delivery through a cervical tear, provoked by prostaglandin‐induced uterine contractions, was described in a G2P0 woman with a history of cervical dilatation and uterine curettage. This rare complication with potentially serious maternal–fetal consequences can be predicted by an aberrant cervical response to prostaglandins in parturients with previous cervical interventions. 相似文献
979.
目的 探讨椎间融合器联合椎弓根钉内固定治疗腰椎退行性疾病患者术后早期下床对腰椎功能恢复及腰腿痛的影响,为患者在临床中进行康复指导提供理论和实践依据.方法 选择腰椎退行性疾病行后路椎间融合器联合椎弓根螺钉内固定患者80例,随机分成观察组和对照组各40例,观察组术后3d佩戴腰部护具下床活动,对照组术后14 d佩戴腰部护具下床活动.比较两组患者术后1、3和6个月的Oswestry功能障碍指数(ODI)及腰腿痛的视觉模拟疼痛评分(VAS).结果 观察组的ODI指数在术后1和3个月明显低于对照组,差异有统计学意义(P<0.05);术后6个月两组比较差异无统计学意义(P>0.05);两组患者的腰腿痛VAS评分在术后1、3和6个月比较,观察组明显低于对照组,差异有统计学意义(P<0.05).结论 腰椎退行性疾病患者行椎间融合器联合椎弓根钉内固定手术术后3d下床可以促进腰椎功能的恢复,减轻腰腿痛,提升手术效果,促进患者康复,是可行性的. 相似文献
980.
取27只健康成年雌性新西兰大白兔于近前交叉韧带股骨止点处完全离断建立双侧急性前交叉韧带完全损伤模型,随机选择一侧膝关节采用自体半腱肌腱增强缝合残端并牵张技术修复前交叉韧带(L 组),对侧行常规前交叉韧带重建(R 组)。结果显示:术后第3、6、10周,L 组移植物在组织学表现如腱骨界面愈合、细胞增殖、血管再生等方面上均优于 R 组;R 组骨-移植物-骨复合体(骨-移植物-残端复合体)的最大载负荷要稍强于 L 组(P <0.05)。 相似文献