全文获取类型
收费全文 | 13496篇 |
免费 | 911篇 |
国内免费 | 212篇 |
专业分类
耳鼻咽喉 | 111篇 |
儿科学 | 768篇 |
妇产科学 | 307篇 |
基础医学 | 1386篇 |
口腔科学 | 210篇 |
临床医学 | 1474篇 |
内科学 | 2140篇 |
皮肤病学 | 309篇 |
神经病学 | 204篇 |
特种医学 | 174篇 |
外国民族医学 | 6篇 |
外科学 | 1116篇 |
综合类 | 1349篇 |
预防医学 | 2791篇 |
眼科学 | 133篇 |
药学 | 1218篇 |
7篇 | |
中国医学 | 147篇 |
肿瘤学 | 769篇 |
出版年
2024年 | 14篇 |
2023年 | 184篇 |
2022年 | 301篇 |
2021年 | 973篇 |
2020年 | 577篇 |
2019年 | 531篇 |
2018年 | 489篇 |
2017年 | 487篇 |
2016年 | 567篇 |
2015年 | 583篇 |
2014年 | 954篇 |
2013年 | 1151篇 |
2012年 | 886篇 |
2011年 | 910篇 |
2010年 | 747篇 |
2009年 | 660篇 |
2008年 | 498篇 |
2007年 | 551篇 |
2006年 | 512篇 |
2005年 | 407篇 |
2004年 | 390篇 |
2003年 | 264篇 |
2002年 | 257篇 |
2001年 | 213篇 |
2000年 | 175篇 |
1999年 | 159篇 |
1998年 | 143篇 |
1997年 | 138篇 |
1996年 | 88篇 |
1995年 | 82篇 |
1994年 | 64篇 |
1993年 | 58篇 |
1992年 | 59篇 |
1991年 | 46篇 |
1990年 | 46篇 |
1989年 | 55篇 |
1988年 | 40篇 |
1987年 | 51篇 |
1986年 | 44篇 |
1985年 | 59篇 |
1984年 | 25篇 |
1983年 | 24篇 |
1982年 | 32篇 |
1981年 | 15篇 |
1980年 | 14篇 |
1979年 | 16篇 |
1978年 | 17篇 |
1976年 | 13篇 |
1975年 | 14篇 |
1974年 | 9篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Candidaemia: a 10-year study in an Indian teaching hospital 总被引:3,自引:0,他引:3
Retrospective evaluation of candidaemia patients was performed in an Indian teaching hospital over a 10-year period. The incidence of patients with candidaemia increased eleven-fold in the second half of the study period (55 patients) compared with the first half (5 patients). Haematological malignancies (11 patients), neonatal septicaemia (9), cardiac abnormalities and cardiac surgery (9) were the commonest underlying diseases in these patients. Candida albicans (50%), C. guilliermondii (17%), C. tropicalis (15%) and C. parapsilosis (8%) were the most common fungal pathogens isolated from blood culture. Therapy with two or more antibiotics (92%), corticosteroid administration (25%), intravascular catheter use for over 24 h (78%) and neutropenia (48%) were the accountable predisposing factors. Prolonged hospitalization (mean average 22.2 days as compared with 11.2 days in other patients) was an added risk factor in these patients. 相似文献
72.
Abstract. Skattum L, MBrtensson U, Sjoholm AG (Lund University, Lund, Sweden). Hypocomple-mentaemia caused by C3 nephritic factors (C3 NeF): clinical findings and the coincidence of C3 NeF type I1 with anti-Clq autoantibodies. 1 Intern Med 1997; 242: 455-64.
Objectives: The main purposes were to document manifestations associated with prolonged or clinical ly unexplained C3 deficiency and to approximate how often hypocomplementaemia of this kind is caused by C3 nephritic factors (C3 NeF), i.e. autoantibodies to alternative pathway C3 convertases. We also wished to distinguish between C3 NeF types I and I1 and to assess coincident autoantibody responses to the collagen-like region of Clq (ClqCLR).
Setting: The investigation was based on serum Samples referred to a specialized laboratory for complement analysis in the course of several years.
Subjects: Twenty-five persons with C3 concentrations lower than 0.43 g L', a third of the normal, were included in the study.
Results: Analysis using three methods provided evidence of C3 NeF in 20 persons with equal frequencies of C3 NeF types I and 11. We also gave evidence of antibody specificity differences for the two types of C3 NeF. Six patients with C3 NeF type I1 showed antibodies to C1 qCLR. Membranoproliferative glomerulonephritis was the predominant diagnosis and two patients had partial lipodystrophy reflecting the wellknown association between these diseases and C3 NeF. Anaphylactoid purpura, systemic lupus erythematosus, and severe infection, mainly meningococcal disease, were also observed.
Conclusions: The study group was probably fairly representative of C3 deficiency syndromes as encountered in clinical practice. The findings emphasize the heterogeneity of C3 NeF, and that acquired C3 deficiency syndromes caused by C3 NeF should perhaps be considered more often in diagnostic work. 相似文献
Objectives: The main purposes were to document manifestations associated with prolonged or clinical ly unexplained C3 deficiency and to approximate how often hypocomplementaemia of this kind is caused by C3 nephritic factors (C3 NeF), i.e. autoantibodies to alternative pathway C3 convertases. We also wished to distinguish between C3 NeF types I and I1 and to assess coincident autoantibody responses to the collagen-like region of Clq (ClqCLR).
Setting: The investigation was based on serum Samples referred to a specialized laboratory for complement analysis in the course of several years.
Subjects: Twenty-five persons with C3 concentrations lower than 0.43 g L', a third of the normal, were included in the study.
Results: Analysis using three methods provided evidence of C3 NeF in 20 persons with equal frequencies of C3 NeF types I and 11. We also gave evidence of antibody specificity differences for the two types of C3 NeF. Six patients with C3 NeF type I1 showed antibodies to C1 qCLR. Membranoproliferative glomerulonephritis was the predominant diagnosis and two patients had partial lipodystrophy reflecting the wellknown association between these diseases and C3 NeF. Anaphylactoid purpura, systemic lupus erythematosus, and severe infection, mainly meningococcal disease, were also observed.
Conclusions: The study group was probably fairly representative of C3 deficiency syndromes as encountered in clinical practice. The findings emphasize the heterogeneity of C3 NeF, and that acquired C3 deficiency syndromes caused by C3 NeF should perhaps be considered more often in diagnostic work. 相似文献
73.
74.
Combined large cell neuroendocrine carcinoma 总被引:1,自引:0,他引:1
Toshiya Bessho Keiya Yokochi Teruhisa Sakurai 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(9):426-428
We report a case of combined large cell neuroendocrine carcinoma. A 78-year-old man with vertigo was referred to our hospital
where chest X-ray revealed a tumor shadow in the right lung. A transbronchial lung biopsy specimen verified a diagnosis of
non-small cell lung carcinoma (cT1N0M0). Right lower lobectomy with mediastinal lymph node dissection (#7,8,9) was performed.
A postoperative histological diagnosis was combined large cell neuroendocrine carcinoma of a component of squamous cell carcinoma
[pT4 (pm) N2M0]. The patient received concurrent chemoradiotherapy due to upper mediastinal lymph node metastasis 4 months
after surgery. The chemoradiotherapy well responded and the patient remains well 9 months after surgery. 相似文献
75.
目的探讨SAP并发深部真菌感染的易感因素以及防治的方法。方法分析1998年9月至2004年10月收治的81例SAP患者资料,其中并发深部真菌感染的21例作为真菌感染组,其余60例作为非感染组,比较两组患者的诊治方法与措施,分析真菌感染的危险因素。结果经糖皮质激素应用、腹腔灌洗、胃肠减压等一系列诊治措施,真菌感染组19例患者病愈出院,2例死亡。两组在糖皮质激素应用、中心静脉置管、全胃肠外营养、空肠营养、呼吸机支持、腹腔灌洗和囊肿穿刺等方面差异显著(P〈0.05)。结论糖尿病、老年、呼吸机支持和重症监护客观因素等为真菌感染的危险因素。合理应用抗生素和预防性应用抗真菌药物可以减少感染机会,提高SAP的救治存活率。 相似文献
76.
E. Faber D. Riegrová M. Jarošová J. Hubácek P. Slezák Z. Pikalová P. Hamal K. Indrák 《Annals of hematology》1996,73(4):195-198
The case report of a 61 year-old man with AML M2 FAB, t(1; 13; 14) and zygomycotic mesenterial thromboangiitis is presented.
Two induction cycles of chemotherapy were administered due to primary drug resistance. They were complicated by pneumonia,
colonic pseudo-obstruction and perforation with peritonitis. The patient died on the 40th day of therapy, 4 days after undergoing
palliative surgery. Zygomycotic thromboangiitis, which very probably contributed to the intestinal perforation, was confirmed
morphologically at necropsy. The novel complex chromosomal translocation t(1; 13; 14) (q31; q32; q24) and the problems connected
with the diagnosis of invasive fungal infections are discussed.
Received: 26 January 1996 / Accepted: 12 June 1996 相似文献
77.
左氧氟沙星治疗细菌性感染70例 总被引:40,自引:2,他引:38
目的:观察左氧氟沙星治疗细菌感染的疗效和安全性。方法:以左氧氟沙星治疗细菌性感染70例(男性35例,女性35例,年龄54±s15a),其中下呼吸道感染40例,尿路感染30例,剂量一般为0.2g,po,bid,疗程7~14d;单纯性下尿路感染为0.2g,po,qd,疗程5~7d。结果:总有效率93%,细菌清除率88%,不良反应轻微,呈一过性,发生率为6%。结论:左氧氟沙星治疗细菌性感染有效而安全。 相似文献
78.
S. Momčilović C. Cantacessi V. Arsić-Arsenijević D. Otranto S. Tasić-Otašević 《Clinical microbiology and infection》2019,25(3):290-309
Background
Parasitic diseases are one of the world's most devastating and prevalent infections, causing millions of morbidities and mortalities annually. In the past, many of these infections have been linked predominantly to tropical or subtropical areas. Nowadays, however, climatic and vector ecology changes, a significant increase in international travel, armed conflicts, and migration of humans and animals have influenced the transmission of some parasitic diseases from ‘book pages’ to reality in developed countries. It has also been noted that many patients who have never travelled to endemic areas suffer from blood-borne infections caused by protozoa. In the light of existing knowledge, this new trend can be explained by the fact that in the process of migration a large number of asymptomatic carriers become a part of the blood bank donor and transplant donor populations. Accurate and rapid diagnosis represents the crucial weapon in the fight against parasitic infections.Aims
To review old and new approaches for rapid diagnosis of parasitic infections.Sources
Data for this review were obtained through searches of PubMed using combinations of the following terms: parasitological diagnostics, microscopy, lateral flow assays, immunochromatographic assays, multiplex-PCR, and transplantation.Content
In this review, we provide a brief account of the advantages and limitations of rapid methods for diagnosis of parasitic diseases and focus our attention on current and future research in this area. The approximate costs associated with the use of different techniques and their applicability in endemic and non-endemic areas are also discussed.Implications
Microscopy remains the cornerstone of parasitological diagnostics, especially in the field and low-resource settings, and provides epidemiological assessment of parasite burden. However, increased use and availability of point-of-care tests and molecular assays in modern era allow more rapid and accurate diagnoses and increased sensitivity in the identification of parasitic infections. 相似文献79.
HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency syndrome (AIDS) patients with opportunistic infections 总被引:1,自引:0,他引:1
During the past three years, an epidemic of acquired immunodeficiency syndromes (AIDS) involving the presence of specific forms of cancer (notably Kaposi's sarcoma) and infection (e.g., pneumocystis carinii) ordinarily seen only in severely immunosuppressed hosts has occurred among active homosexuals, Haitian immigrants, drug users, and hemophiliacs in large cities in the United States and elsewhere. An as yet unidentified viral agent is presumably the cause of the initial immunodeficiency and host genetic factors may influence the subsequent development of different clinical symptoms in different patients. We have previously reported that the HLA antigens DR5 and DR2 are associated with susceptibility to Kaposi's sarcoma (KS) in different Caucasian subpopulations. We now have also noted that AIDS patients with opportunistic infections have a normal frequency of DR2 and DR5 and a significantly increased frequency of DR3 and that the ultimate clinical expression of AIDS in patients with unexplained lymphadenopathy may depend upon genetic factors associated with these particular DR types. 相似文献
80.
John G. Guccion Debra A. Benator Jack Zeller Basel Termanini Nirmal Saini 《Ultrastructural pathology》1995,19(1):15-22
Two cases of intestinal spirochetosis (IS) with acquired immunodeficiency syndrome are reported. In case 1, a 48-year-old homosexual black man presented with a 1-month history of alternating watery diarrhea and constipation, which dissipated following the removal of two colonic hyperplastic polyps containing IS. In case 2, a 26-year-old homosexual black man presented with a 3-month history of persistent bloody diarrhea and was found to have chronic shigellosis and IS. Pathologic findings of IS were similar in both cases. Basophilic fringes typical of IS covered the surfacing colonic epithelium and consisted of dense growths of spirochetes adherent to and oriented perpendicular to the plasma membranes of the surfacing epithelium. The spirochetes measured 3 to 5 μm in length and 0.2 (im in width, contained four to eight axial fibrils, and closely resembled Brachyspira aalborgi ultrastructurally. These cases are notable because the histopathologic changes of IS were more extensive than generally described. There was involvement of both the right colon and rectum by IS in case 2, and in both cases there was extension of the IS down into the crypts of Lieberkiihn, spirochetal invasion of the colonic mucosa, and a conspicuous inflammatory response by macrophages in the underlying lamina propria. 相似文献