复方通络中药改善肥胖患者血管内皮细胞功能障碍研究

目的观察复方通络中药对单纯性肥胖患者血管内皮依赖性舒张功能障碍的干预效应，探讨其作用机制。方法应用高分辨血管超声检查选择血管内皮依赖性舒张功能障碍[以血流介导的肱动脉扩张率（FMD）表示]肥胖患者（65例），随机分为通络中药治疗组和对照组。治疗组32例，对照组33例。治疗组给予辛香疏络2号胶囊，3g／次，每日3次；对照组给予淀粉胶囊，3g／次，每日3次。共用药12周，分别测定用药前后FMD、肱动脉内径（D0），同时检测辛香疏络2号治疗前后患者血清总胆固醇（TC）、三酰甘油（TG）的变化。结果治疗后治疗组FMD较对照组明显增加（P〈0．01），TC、TG较治疗前及对照组明显下降（P〈0．01）。结论复方通络中药辛香疏络2号胶囊可明显改善肥胖患者血管内皮障碍，调节血脂可能是其改善血管内皮功能机制之一。     

活血熄风方对局灶性脑缺血大鼠内皮素1和一氧化氮含量的影响

目的观察活血熄风方对局灶性脑缺血模型大鼠血液和脑组织中内皮素1（ET-1）和一氧化氮（NO）含量的影响，探讨其脑保护的作用机制。方法雄性WiStar大鼠40只随机分为5组：假手术组、模型组及活血熄风方高、中、低剂量组，每组8只。采用光化学法建立局灶性脑缺血大鼠模型，造模前7d灌胃给药，活血熄风方高、中、低剂量组分别给予活血熄风方20、10、5g／（kg·d），假手术组和模型组给予等体积蒸馏水灌胃，造模后24h分别取血及脑组织，放射免疫法测定模型大鼠血浆及脑组织中ET-1含量，分光光度法测定血清及脑组织中N0的含量。结果活血熄风方能降低模型大鼠血浆及脑组织中ET-1含量，降低脑组织中NO含量，升高血清中N0含量，与模型组比较，差异有统计学意义（P〈0．05或P〈0．01）。结论活血熄风方对局灶性脑缺血模型大鼠的保护作用可能与其降低血浆及脑组织中ET-1含量，降低脑组织中N0含量，升高血清N0含量，从而调节ET-1／N0比值有关。     

中西医结合治疗妊娠期肝内胆汁淤积症初探

目的 评估复方丹参注射液联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的临床疗效及对新生儿预后的影响。     

复方丹参滴丸对不稳定型心绞痛患者血浆内皮素和血小板α-膜颗粒蛋白的影响

目的观察复方丹参滴丸对不稳定型心绞痛患者的临床疗效及血浆内皮素（ET）和血小板α-膜颗粒蛋白（GMP-140）水平的影响。方法168例不稳定型心绞痛患者分为常规治疗组（79例）和复方丹参滴丸组（89例）。所有入选患者均接受硝酸酯类、美托洛尔（或钙拮抗剂）及阿司匹林治疗，复方丹参滴丸组在上述治疗基础上加用复方丹参滴丸10粒，每日3次，连用8周。观察统计两组治疗前1周和治疗结束后1周心绞痛发作次数及自拟的疼痛强度及持续时间记分值，检测治疗前后患者血浆ET和GMP-140水平的变化。结果复方丹参滴丸组和常规治疗组比较，治疗后疼痛发作频率、疼痛强度及持续时间记分均有明显减少，而复方丹参滴丸组的降低程度比常规治疗组明显（P〈0．05）。两组可改善不稳定型心绞痛患者心电图ST段的偏移，而复方丹参滴丸组的疗效比常规治疗组显著（P〈0．05）。两组治疗后血浆ET和GMP-140水平均明显减低，而复方丹参滴丸组的疗效比常规治疗组显著（P〈0．01）。结论复方丹参滴丸治疗不稳定型心绞痛患者疗效明显高于常规治疗，可能与改善血管内皮功能、抑制血小板聚集密切相关。     

复方丹参注射液与维生素B6、C注射液配伍稳定性试验

本文观察了复方丹参注射液与维生素B6、维生素C注射液的配伍稳定性，结果表明复方丹参注射液与维生素B6注射液可以在4h内配伍使用，而不能与维生素C配伍。     

复方甘油注射液长期毒性试验

复方甘油注射液系新脱水药。为了确定该药反复使用有无蓄积性中毒作用及最大无作用量，作者以大鼠和狗进行为期２８天的长期毒性试验。两种动物皆设立生理盐水对照组，低剂量组（大鼠为１０ｍｌ／ｋｇ，狗为１．７ｍｌ／ｋｇ），高剂量组（大鼠为４５ｍｌ／ｋｇ，狗为１３ｍｌ／ｋｇ）。按规定剂量每天一次静注给药，连续２８天。结果表明，两种动物均未出现明显的机能性变化，以及特异性靶器官、靶细胞的损害。故认为大鼠和狗对受试物的最大无作用量分别大于４５ｍｌ／ｋｇ和１３ｍｌ／ｋｇ。     

A Comparative Study of Dihydroartemisin in Compounds in Treatment of Uncomplicated Falciparum Malaria in Kampong of Cambodia

Objective: To compare the safety and efficacy of two compounds of dihydroartemisinin(DHA) -Artekin and Artekin (T) in the treatment of uncomplicated falciparum malaria. Methods:The regimen of 8-tablet for 2 days of Artekin and Artekin (T) were applied to 100 patients with uncomplicated falciparum malaria, who were randomly divided into two groups. Each group contained 50 cases. The cure rate, the mean parasites clearance time, the mean fever clearance and side-effects were observed to assess the safety and efficacy of the compounds used. Results: The mean parasites clearance time was 31. 7±9.0 hours in the Artekin group and 32. 8±8. 8 hours in Artekin (T) group respectively; the mean fever clearance time was 12. 7±7. 2 hours in Artekin group and 16. 5±7. 9 hours in Artekin (T) group; there were no recrudescence case in both groups within the 28 days of follow-up, the cure rates in Artekin group and Artekin (T) groups were 100%. It indicated that the tolerability of both compounds were very good, the     

H—TdR前体掺入技术在复方中药抗癌制剂研究中的应用

将一种快速、灵敏、可靠、简便的抗癌活性微量测定技术——~3H—TdR前体掺入技术用于复方中药抗癌制剂制备工艺筛选,短期内即拟定出较合理的工艺,经临床及14项生物学指标综合评定,该制剂疗效好,无明显的毒副作用。表明把一些快速、灵敏的医学检测技术引入药物制备工艺、质量标准及稳定性研究,可克服由于活性成分不清楚带来的一些困难,拓宽了研究途径,提高了研究水平。     

Leukocytosis and low serum IgA in workers exposed to the epoxy compound,t-methyl-3-phenylglycidate

Summary Forty-nine out of 54 male workers engaged in the production of an epoxy compound, t-methyl-3-phenylglycidate, showed skin symptoms in varing degrees that may be due to the skin-irritative effect of the compound. The exposed workers were also shown to have subjective symptoms which may be related to the irritative property of the compound on surface tissue. Laboratory examinations on the blood obtained from the exposed workers showed significantly higher values of leukocyte concentration as compared with the non-exposed controls. This was chiefly caused by the increase of neutrophilic granulocytes and T-cell lymphocytes. Serum IgA levels of the exposed workers were shown to be significantly lower than those of the control group. Hemoglobin concentration, hematocrit value and red cell count of the exposed workers remained at the same level as those of the control subjects. Liver or kidney damage was not found in biochemical analyses on the sera of exposed workers.     

药用真空铝塑复合薄膜的质量试验

 根据文献对药用真空铝塑复合薄膜进行了理化性能、密闭性能、急性毒性试验。结果表明，目前国产药用真空铝塑复合薄膜的铅盐、高锰酸钾还原性物质，蒸发残渣、密闭性能均不合格，但急性毒性试验符合规定。建议改进生产，提高质量。