HPLC法测定派瑞松乳膏中曲安奈德和硝酸益康唑的含量

目的 HPLC法测定派瑞松乳膏中曲安奈德和硝酸益康唑的含量。方法色谱柱为Dionex C18(200 mm×4.6 mm,5μm);流动相为质量分数为0.5%的三乙铵溶液(乙酸调节pH为3.0)(A)-乙腈(B),线性梯度洗脱;流速为1.0 mL·min-1;柱温为30℃;检测波长为235 nm。结果曲安奈德和硝酸益康唑在13.57⁴2.28 mg·L-1和131.342.28 mg·L-1和131.3⁴25.4 mg·L-1内,两者峰面积线性良好,R分别为0.999 8和0.999 0。平均回收率分别为99.8%和100.4%,RSD分别为0.99%和0.86%(n=9)。结论 HPLC法可用于派瑞松乳膏中曲安奈德和硝酸益康唑的含量测定。     

醋酸曲安奈德局部注射联合手术切除治疗耳部瘢痕疙瘩

目的总结注射醋酸曲安奈德控制瘢痕疙瘩生长后联合手术切除耳垂瘢痕疙瘩的临床经验。方法采用耳垂瘢痕疙瘩局部注射醋酸曲安奈德治疗3~4次后,手术切除耳垂瘢痕疙瘩,术中保留部分瘢痕疙瘩边缘皮肤并行无张力缝合,术后观察6~24个月。结果本组31只耳手术切口全部一期愈合,随访6~24个月,26只耳治愈,4只耳有效,1只耳无效,有效治愈率约96.8%。结论醋酸曲安奈德局部注射后手术切除能有效治疗耳部瘢痕疙瘩。     

Malignant transformation of oral lichen planus by a chronic inflammatory process. Use of topical corticosteroids to prevent this progression?

Background: Oral lichen planus is a potentially malignant disorder with a capacity, although low, for malignant transformation. Of all the factors related to the process of malignant transformation, it is believed that the chronic inflammatory process plays a key role in the development of oral cancer. This inflammatory process is capable of providing a microenvironment based on different inflammatory cells and molecules that affect cellular growth, proliferation and differentiation. Objectives: The objectives of our study are: to review the available evidence about the possible relationship between the chronic inflammatory process present in oral lichen planus and its malignant transformation, to discuss the potential therapeutic implications derived from this relationship and to study the role that topical corticosteroids play in the control of oral lichen planus inflammation and its possible progression to malignant transformation. Conclusion: The maintenance of a minimum dose of topical corticosteroids could prevent the inflammatory progression of oral lichen planus to oral cancer.     

曲安奈德不同给药方式治疗黄斑水肿的临床疗效观察

目的通过玻璃体腔注射和后Tenon囊下注射曲安奈德(TA),观察和比较两种不同给药方式治疗黄斑水肿的疗效。方法对符合条件的黄斑水肿患者50例(50眼),数字随机法分为两组,即玻璃体腔注射组(IVTA)和后Tenon囊下注射组(PSTA),每组25例(25眼),随访6个月,对比观察两组用药前后的视力、黄斑中心厚度、眼压及并发症情况。结果两组治疗前及治疗后1、3、6个月各时间点组内对比在视力、黄斑中心厚度以及眼压差异方面均有统计学意义(P=0.000);两组治疗前在视力、黄斑中心厚度以及眼压差异均无统计学意义(P>0.05);治疗后1、3、6个月时,黄斑厚度及视力与术前差异均无统计学意义(P>0.05)。随访3个月时,复发IVTA组2例、PSTA组4例;6个月时,复发IVTA组4例、PSTA组8例。IVTA组眼压升高(>8mmHg)8例,假性眼内炎1例。结论 TA两种不同给药方式均可减轻黄斑水肿,提高患者部分视力,均是治疗糖尿病和视网膜静脉阻塞引起黄斑水肿的有效方法。就并发症而言,后Tenon囊下注射安全性更高,给药更方便,重复性更好。     

Plantar fasciitis and impaired vision: A case report

We report a case of acute bilateral central serous chorioretinopathy in a patient who received a local injection of triamcinolone for the treatment of plantar fasciitis. Central serous chorioretinopathy is a serious, though rare, ocular complication of steroid treatment and it may occur even when the steroid is administered at a site as remote from the eye as the foot. This case report highlights the need for greater awareness of this complication amongst all medical personnel who prescribe steroids. It is advisable that patients, undergoing steroid treatment for any cause, be alerted to the risk of sudden visual impairment.     

Results of a combination of bleomycin and triamcinolone acetonide in the treatment of keloids and hypertrophic scars

While treatment of keloids and hypertrophic scars normally shows modest results, we found that treatment with bleomycin was more promising. The present study was divided into two parts. In the first part the aim was to show the results using a combination of bleomycin and triamcinolone acetonide per cm² (BTA). In the second part the objective was to determine the response to both drugs in large keloids that were divided into 1 cm² squares, treating each square with the dose previously used. In the first part of the study, the clinical response of 37 keloids ranging from 0.3 to 1.8 cm² treated with BTA were followed up over a period of 1- 2 years. 0.375 IU bleomycin and 4 mg triamcinolone acetonide were injected every 3 months. In the second part of the study we reviewed the clinical response in six patients with large keloids. The monthly dose administered never exceeded 3 IU of bleomycin. The first study showed 36 keloids (97.29%) softening after the first dose. In the second study, 5 showed different responses (the response was complete in the four smaller keloids). The largest keloid needed 9 doses to achieve an improvement of 70%. In conclusion, combined treatment with 0.375 IU of bleomycin and 4mg of triamcinolone acetonide to 1 cm² was considered to be an acceptable procedure for the treatment of keloids. The best results were obtained in keloids over 1 cm² or when divided into 1 cm² square areas. Larger series need to be performed in order to confirm these results..     

A prospective,randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis

Background Topical aloe vera (AV) has been used to treat various skin conditions, including psoriasis, with good results. Objectives This study aims to compare the efficacy of AV and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque psoriasis. Methods A randomized, comparative, double‐blind, 8‐week study was designed. Eighty patients randomly received AV or 0.1% TA cream and their clinical response were evaluated using the Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI). Results After 8 weeks of treatment, the mean PASI score decreased from 11.6 to 3.9 (–7.7) in the AV group and from 10.9 to 4.3 (–6.6) in the TA group. Between‐group difference was 1.1 (95% confidence interval –2.13, –0.16, P = 0.0237). The mean DLQI score decreased from 8.6 to 2.5 (–6.1) in the AV group and from 8.1 to 2.3 (–5.8) in the TA group. Between‐group difference was 0.3 (95% confidence interval –1.18, –0.64, P = 0.5497). There was no follow‐up period after the 8‐week treatment. Conclusions AV cream may be more effective than 0.1% TA cream in reducing the clinical symptoms of psoriasis; however, both treatments have similar efficacy in improving the quality of life of patients with mild to moderate psoriasis.     

曲安奈德不同给药方式的临床观察

目的评价曲安奈德经不同给药方式治疗人工晶状体植入术后迟发性虹膜睫状体炎、早期甲状腺相关眼病及婴幼儿眼睑血管瘤的疗效。方法曲安奈德半球周注射治疗人工晶状体植入术后迟发性虹膜睫状体炎60例(60眼),曲安奈德眶周注射治疗早期甲状腺相关眼病38例(46眼),曲安奈德瘤体内注射治疗婴幼儿眼睑血管瘤16例(16眼)。结果迟发性虹膜睫状体炎60眼中56眼治愈,有效率93.33%;早期甲状腺相关眼病46眼中42眼有效,有效率91.30%;婴幼儿眼睑血管瘤16眼中14眼有效,有效率87.50%。结论曲安奈德经不同的给药方式局部注射能迅速而有效地治愈迟发性虹膜睫状体炎,早期甲状腺相关眼病及婴幼儿眼睑血管瘤,是治疗上述疾病可行而有效的方法。