Accelerated fractionation in esophageal cancers: A multivariate analysis on 88 patients

: Accelerated fractionation was used to shorten overall treatment time to increase locoregional control and cause-specific survival.

: Eighty-eight patients with cancer of the esophagus ineligible for surgery were entered in the study between 1986 and 1993. Neoadjuvant chemotherapy was given to 64% of patients. Accelerated radiotherapy using the concomitant boost technique delivered a median dose of 65 Gy in a median overall treatment time of 32 days.

: The 3-year acturial local control rate in patients with T1, T2, and T3 tumors was 71%, 42%,and 33%, respectively. The 3-year cause-specific survival rates were 40%, 22%, and 6%, respectively. Sixteen percent of patients experienced Grafe 3 esophagitis. Late toxicity included esophageal stenosis and pulmonary fibrosis in 8% and 9% of the patients, respectively. Multivariate analysis demonstrated that T stage and overall treatment time were prognostic factors for cause-specific survival. T stage and neoadjuvant chemotherapy were independent prognostic factors for locoregional control.

: These findings suggest that accelerated giben in an overall treatment time of <35 days might be beneficial for easy-stage cancer of the esophagus. Neoadjuvant chemotherapy is not recommended, as it was a significant adverse prognostic factor in the multivariate analysis for local control. Accelerated fractionation can be carried out with modeate acure and late toxicity.     

抗癌宝口服液治疗中晚期恶性肿瘤103例临床观察

目的：观察中药抗癌宝口服液治疗中晚期恶性肿瘤临床效果。方法：１０３例患者随机分为抗癌宝观察组与化疗对照组，对两组疗效作比较。结果：观察组患者免疫功能，近期有效率（ＣＲ＋ＰＲ），生存质量，１、２、３年生存期及中位生存时间，癌胚抗原下降水平，明显高于对照组，且有显著性差异。结论：抗癌宝具有抑制肿瘤生长，延长生存时间，提高生存质量之效。     

普洱茶籽的化学成分研究

普洱茶籽乙醇提出物的正丁醇萃取部分,经酸水解后,分离出5种成分,经光谱和化学分析,分别鉴定为二十八烷烃,柚皮素和3种新酯酰基皂甙元22-O-当归酸酯茶皂甙元B,22-O-当归酸酯茶皂甙元E和22-O-当归酸酯茶皂甙元A。     

Aggregation of childhood leukemia in geographic areas of Greece)

A total of 872 children aged up to 14 years, who were diagnosed withleukemia in Greece during the decade 1980-89, were allocated by place ofresidence to the 601 administrative districts of the country. Evaluation ofspatial clustering was done using the Potthoff-Whittinghill method, whichvalidly assesses heterogeneity of leukemia risk among districts with variableexpected numbers of cases. There was highly significant evidence for spatialclustering occurring particularly among children living in urban and, to alesser extent, semi-urban areas. The evidence was stronger for childrenyounger than 10 years old, applied also to children in different five-yearage groups, and persisted when cases of acute lymphoblastic leukemia wereanalyzed separately. These findings provide support to the hypothesis thatlocalized environmental exposures could contribute to the etiology ofchildhood leukemia, but they cannot distinguish between exposures of physicalor chemical nature, nor can they exclude socially conditioned patterns ofexposure to infectious agents.     

世界中西医结合大会在京召开──交流中西医结合在理论、临床、教育及政策管理方面经验

世界中西医结合大会在京召开──交流中西医结合在理论、临床、教育及政策管理方面经验人民日报北京１０月２７日讯世界中西医结合大会今天在北京国际会议中心开幕。大会以“继承、发扬、结合、创新”为主题，交流重点是中西医结合在理论、临床、教育及政策管理等各方面的...     

复方三姐妹片治疗慢性乙型肝炎远期疗效观察

目的：观察复方三姐妹片治疗慢性乙型肝炎远期疗效。方法：用复方三姐妹片治疗慢性乙型肝炎２４例，与用益肝灵治疗的２２例作对照，治疗后随访１年。结果：治疗组治疗结束时和１年后有效率分别为８３３％和９５８％，ＨＢｅＡｇ，ＨＢＶ－ＤＮＡ阴转率分别为５００％，５８３％和５８３％，５８３％，均显著高于对照组（Ｐ＜００１）。治疗组治疗结束时ＡＬＴ和Ａ／Ｇ的复常率分别为９１７％和７２７％，１年后则分别为１００％和９５８％，均高于对照组（Ｐ＜００５）。结论：复方三姐妹片为治疗慢性乙型肝炎的有效药物，且远期疗效优于近期疗效。     

抗HBc阳性,HBsAg阴性献血者乙型肝炎病毒感染性研究

目的为预防输血后乙型肝炎，是否有必要在献血者中加做抗－ＨＢｃ筛查以及采取何种取舍标准？为此，对常规筛查合格的献血者血液进行了抗－ＨＢｃ滴度与ＨＢＶＤＮＡ相关性的研究。方法用免疫－套式ＰＣＲ法检测了２９７份不同滴度组抗－ＨＢｃ阳性血液的ＨＢＶＤＮＡ。结果在４份抗－ＨＢｃ滴度≥１１２８的血液中检出１例ＨＢＶＤＮＡ，而在另７５份抗－ＨＢｃ滴度＜１１２８的血液中未检出，ＨＢＶＤＮＡ与抗－ＨＢｃ滴度之间有显著相关性。在２１８份抗－ＨＢｃ／抗－ＨＢｓ双阳血液及５０份抗－ＨＢｃ阴性血液中未检出ＨＢＶＤＮＡ。结论仅含高滴度单项抗－ＨＢｃ的血液可能具有传染性；ＨＢＶＤＮＡ在抗－ＨＢｃ阳性血液中的总检出率低，仅为０．３４％（１／２９７）。建议将有限的资金首先用于进一步提高现有献血者ＨＢｓＡｇ检测试剂的灵敏度（目前为１ｎｇ／ｍｌ），或许更为有效。     

功能性消化不良胃排空时间测定及胃回归煎剂对其疗效研究

目的：观察功能性消化不良（ＦＤ）患者胃排空时间及中药胃回归煎剂对其疗效，方法：对２０名健康者和６４例ＦＤ患者，应用实时超声显像法进行胃排空时间测定。受试者空腹、饮水后０、１０、２０、３０、４０、５０ｍｉｎ测定胃窦面积和胃体－底交界区前后壁切面内径，测定胃起始收缩时间和２ｍｉｎ收缩次数；从ＦＤ组中随机选择２０例患者给予中药胃回归煎剂治疗，每次１００ｍｌ，１日３次，连服２周，观察胃排空及临床症状改善情     

含编码人精子膜多肽cDNA和乙肝表面抗原基因的重组痘苗病毒

合成编码一种人精子膜蛋白YWK-Ⅱ胞外区的一段多肽片段的双链寡核苷酸链,HSD-2a.将HSD-2a和3’端乙肝表面抗原主S基因连接并与pUC18质粒重组.经鉴定的重组质粒用BamH Ⅰ和EcoRl酶切后,可分离纯化得到HSD-2a和HBsAg的主S基因连接片段,将该连接片段插入痘苗病毒通用表达载体pGJP-5的痘苗病毒启动子P_(7.5)下游,构建成重组质粒pGJP-HSD/HBs.将该重组质粒传染已感染了天坛痘苗病毒的猴肾细胞CV-1,pGJP-5中含有的TK基因与出发株病毒基因组的TK基因发生体内同源重组,构成重组痘苗病毒vv-HSD/HBs.HuTK~-细胞经vv-HSD/HBs感染后,在5-溴脱氧尿苷存在下进行空斑分析,筛选出TK~-重组病毒.应用ELISA方法对已感染了重组病毒的HuTK~-细胞培养上清和细胞裂解液测定,表明有HSD-2a编码的多肽片段的表达.Western-blot法分析呈现28和30Kd两条显色带.重组痘苗病毒vv-HSD/HBs有可能作为抗生育疫苗用途.